Hello freesurfers, I wanted to get your opinion on altering the white matter low limit in the mri_segment command through attaching the "-seg-wlo" flag onto -autorecon2. I am working on a Frontotemporal Dementia cohort. In patients with severe atrophy, there always tends to be a great deal of both white matter and pial surface underestimation in the anterior temporal and dorsal frontal areas. I have found that lowering the white matter low limit does a fantastic job of fixing the surface underestimations in those regions-saving the numerous hours of labor required to manually fix these problem areas with control points.
I was hoping someone could provide insight into what exactly changing this value is doing to the data. Does changing this value lead to inaccuracies that I am not seeing? Most importantly, is it safe to mix cases where I set the white matter low limit to 60 (or 40 in some severe cases) with other cases that retain their default value of 90 in the same dataset? Thank you! Gabe Gabe Marx Clinical Research Coordinator UCSF Memory & Aging Center 675 Nelson Rising Lane, Suite 190 San Francisco, CA 94158 T: (415) 476-3861
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