Hi Steano
a) You could do this but then you are testing a somewhat different
hypothesis - that the change in a specific structure is more than the
overall change in gray matter. Thus for example, widespread atrophy would
be regressed out. If that's what you are interested in, then this approach
is fine.
b) Our analysis is always in individual subject space. You can transform to
a common space using mri_vol2vol if you want.
cheers
Bruce
On Tue, 27 Jan 2015, std...@virgilio.it wrote:
Hi list,
please, I have two questions:
a) subcortical volume correction in cross-sectional studies could be done by
using total GM as covariate instead of eTIV?
b) relatively to group subcortical analysis in cross-sectional studies, the
anatomical images should be necessarily transformed in common space or is
possible to perform the analysis in native space?
The registration in common space should minimize issues due to different
head size. The computation on native space could bias the results
considering the different head sizes among subjects?
Thanks,
Stefano
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