Hi Bruce,

Thanks so much! We do have a bandwidth matched T2-space. So should that be fed 
into recon-all at the same time as the MEMPRAGE as a second series? 

best,
John




> On 8/18/15, at Tue,Aug 18 - 8:32:00 PM, Bruce Fischl 
> <fis...@nmr.mgh.harvard.edu> wrote:
> 
> Hi John
> 
> the MEFLASH never achieved as good cortical contrast as the memprage, so for 
> cotical stuff we still recomment memprage. And yes, feeding the RMS to 
> recon-all will be fine. If you can get a readout/bandwidth matched T2-space 
> or FLAIR that can be a pretty big help as well for avoiding dura
> 
> cheers
> Bruce
> 
> On Tue, 18 Aug 2015, John Pyles wrote:
> 
>> Hi all,
>> 
>> We have recently installed the FreeSurfer suggested morphometry sequences on 
>> our Siemens Verio 3T. Specifically, the multiecho MPRAGE (MEMPRAGE), and 
>> multiecho FLASH (MEFLASH). Our goal is to get the best FreeSurfer 
>> reconstruction results possible for use with fMRI surface analyses, 
>> diffusion imaging, and other purposes. For the current project, scan time is 
>> not at a premium since we have 60-90min budgeted for anatomical and 
>> diffusion weighted scans. We’re just looking for the best results.
>> 
>> However, after looking through the wiki and email archives, I’m having a 
>> hard time figuring out what the most up to date recommendations are for what 
>> sequences to use and how to use them with recon-all.
>> 
>> Some specific questions:
>> 
>> 1) The original 2009 "Suggested Morphometry Protocols” document, the MEFLASH 
>> seems to be recommended as the best sequence to use for whole-brain 
>> segmentation. But other more recent posts to the email list suggest using 
>> MEMPRAGE as the default protocol. We also have a very nice T2-SPACE protocol 
>> we’ve been running. What is the current recommendation?
>> 
>> 2) Is the procedure for using MEMPRAGE with recon-all to just input the RMS 
>> scan and not the 4 different echos?
>> 
>> 3) Is it possible to use the MEFLASH scans with recon-all? If so, how are 
>> they input and is processing of the two different echo time scans required 
>> before running recon-all? The wiki entry on MEF is from 2008, so I’m not 
>> sure what’s happened since then.
>> 
>> 4) What is the current recommendation on using the -3T and -mprage flags 
>> with recon-all?
>> 
>> 5) Since we are scanning on a Siemens Verio instead of the TIM Trio scanners 
>> I believe the sequences were developed on, we have had to modify some 
>> protocol parameters. If anyone has been successfully scanning MEFLASH and/or 
>> MEMPRAGE on a Verio or possibly Skyra and has good parameters to use that 
>> would be great. Our test scans look good, but there is always room for 
>> improvement.
>> 
>> 6) Finally, is 1mm isovoxel still recommended? Or should we try to push the 
>> resolution below 1mm?
>> 
>> Thanks so much in advance for any advice!
>> 
>> best regards,
>> John
>> 
>> ______________________________________
>> 
>> John Pyles, Ph.D.
>> Research Scientist
>> Center for the Neural Basis of Cognition
>> Department of Psychology
>> Carnegie Mellon University
>> email: jpy...@cmu.edu
>> phone: 206.552.0107
>> ______________________________________
>> 
>> 
>> 
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