Hi Martin, I understand for the multiple comparisons problem. But if I consider a voxel-by-voxel analysis just as hippocampal volume (lme_fit_FS for estimation), how could I consider a correction for multiple comparisons in this univariate case ?
Shouldn't I use the lme_mass_fit or lme_mass_fit_vw functions in my mass univariate case ? If yes, how do I have to format my 3D FA volume as input of the LME toolbox ? Best regards, Matthieu ------------------------------------- Matthieu Vanhoutte, MSc Research Engineer - Department of Neuroradiology Regional University Hospital, Lille, France 2015-09-29 16:34 GMT+02:00 Martin Reuter <mreu...@nmr.mgh.harvard.edu>: > Hi Matthieu, > > yes, multiple comparisons are a problem for any mass univariate approach. > You can use the FDR2 correction (in the lme matlab tools) which is less > conservative than standard FDR. You can also work in specific ROI's and > average there, to reduce the number of comparisons. > > Best, Martin > > > On 09/29/2015 09:11 AM, Matthieu Vanhoutte wrote: > > Hi Martin, > > Thank you for your answer. > > However, I would like to consider FA maps as a mass-univariate problem and > not a univariate voxel-by-voxel as hippocampal volume. Indeed, my voxels > aren't independant, are they ? So, how to correct for multiple comparisons > then ? > > Best regards, > > Matthieu > > 2015-09-29 15:04 GMT+02:00 Martin Reuter <mreu...@nmr.mgh.harvard.edu>: > >> Hi Matthieu, >> >> if all your images are perfectly registered, you can do LME on a >> voxel-by-voxel basis, just as if you had hippocampal volume or any other >> ROI measure. >> >> Best, Martin >> >> >> On 09/29/2015 06:46 AM, Matthieu Vanhoutte wrote: >> >> Dear experts, >> >> I would like to know if it is possible to make a longitudinal study with >> LME toolbox from volume FA maps registered in a common space ? >> >> I don't have T1 images so the recon-all process couldn't be processed. >> But if I put my 3D FA volume of dim = [nx,ny,nz] in a 1D nx*ny*nz voxels >> format, could it be in good way for LME ? >> >> Thanks for helping ! >> >> Best regards, >> >> Matthieu >> >> >> _______________________________________________ >> Freesurfer mailing >> listfreesur...@nmr.mgh.harvard.eduhttps://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer >> >> >> -- >> Martin Reuter, PhD >> Assistant Professor of Radiology, Harvard Medical School >> Assistant Professor of Neurology, Harvard Medical School >> A.A.Martinos Center for Biomedical Imaging >> Massachusetts General Hospital >> Research Affiliate, CSAIL, MIT >> Phone: +1-617-724-5652 >> Web : http://reuter.mit.edu >> >> >> _______________________________________________ >> Freesurfer mailing list >> Freesurfer@nmr.mgh.harvard.edu >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer >> >> >> The information in this e-mail is intended only for the person to whom it >> is >> addressed. If you believe this e-mail was sent to you in error and the >> e-mail >> contains patient information, please contact the Partners Compliance >> HelpLine at >> http://www.partners.org/complianceline . If the e-mail was sent to you >> in error >> but does not contain patient information, please contact the sender and >> properly >> dispose of the e-mail. >> >> > > > _______________________________________________ > Freesurfer mailing > listfreesur...@nmr.mgh.harvard.eduhttps://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > > -- > Martin Reuter, PhD > Assistant Professor of Radiology, Harvard Medical School > Assistant Professor of Neurology, Harvard Medical School > A.A.Martinos Center for Biomedical Imaging > Massachusetts General Hospital > Research Affiliate, CSAIL, MIT > Phone: +1-617-724-5652 > Web : http://reuter.mit.edu > > > _______________________________________________ > Freesurfer mailing list > Freesurfer@nmr.mgh.harvard.edu > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > > The information in this e-mail is intended only for the person to whom it > is > addressed. If you believe this e-mail was sent to you in error and the > e-mail > contains patient information, please contact the Partners Compliance > HelpLine at > http://www.partners.org/complianceline . If the e-mail was sent to you in > error > but does not contain patient information, please contact the sender and > properly > dispose of the e-mail. > >
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