Hi Xiaowei,
this was my mistake when I wrote the article in the wiki. The images do not 
need to be in the same orientation (I already changed this in the wiki). They 
need to be coarsely registered in physical coordinates (i.e., the need to look 
approximately registered when you open them in FreeView). If you manually 
rotate / translate the T2, make sure that you check the "do not resample" box 
when you save the rotated scan in order not to lose information.
Cheers,
/Eugenio

Juan Eugenio Iglesias
Postdoctoral researcher BCBL
www.jeiglesias.com
www.bcbl.eu

Legal disclaimer/Aviso legal/Lege-oharra: www.bcbl.eu/legal-disclaimer

----- Original Message -----
From: "Bruce Fischl" <fis...@nmr.mgh.harvard.edu>
To: "Xiaowei Zhuang" <zhua...@ccf.org>
Cc: "Freesurfer support list" <freesurfer@nmr.mgh.harvard.edu>
Sent: Wednesday, March 16, 2016 11:16:48 PM
Subject: Re: [Freesurfer] Hippocampal subfield segmentation with T1&T2

Hi Xiaowei

you can try mri_robust_register --cost nmi or --cost mi, then give the 
resulting transform to mri_convert -at transform.lta -rl T2.mgz


The "-rl T2.mgz" tells mri_convert to "reslice like" the T2, so they will 
have the same geometry. You can also try mri_coreg if you like instead of 
mri_robust_register if it doesn't work well

cheers
Bruce


On Wed, 16 Mar 2016, Zhuang, Xiaowei wrote:

> 
> Dear Freesurfer expert,
> 
>  
> 
> I am using Freesurfer V6.0 beta version to run the hippocampal subfield
> segmentation with 2 inputs, a standard T1 and a high resolution T2.
> 
>  
> 
> Below are the details about the 2 images.
> 
>  
> 
> T1: resolution: 0.8*0.8*0.8 mm,  orientation: Sagittal(S>T4.1>C-0.8)
> 
> T2: resolution: 0.4*0.4*1.5 mm, orientation: oblique coronal(C>T-14.5>S1.5).
> 
>  
> 
> The instruction says in order to use both of them for hippocampal
> segmentation, T2 should be in the same orientation as T1. Therefore, the two
> images cannot be used directly.
> 
>  
> 
> Is it possible for me to do some reorient preprocess on the T2 image and
> then run through the segmentation?
> 
>  
> 
> Or is it possible to coregister the T1 into T2 space, making them both high
> resolution and run through the segmentation? Will this affect the Freesurfer
> pipeline and the final subfields output?
> 
>  
> 
> Any suggestion will help.
> 
>  
> 
> Sincerely thanks,
> 
> Xiaowei.  
> 
>  
> 
>  
> 
>  
> 
> Cleveland Clinic logo
> 
>  
> 
> Xiaowei Zhuang   |  Research Engineer      |  Lou Ruvo Center for Brain
> Health
> 
>  Cleveland Clinic  |  888 W Bonneville Ave.   |  Las Vegas, NV
> 89106  | (702) 685-6051
> 
>  
> 
>  
> 
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