On 08/23/2016 03:18 AM, maaike rive wrote: > > Dear Douglas, > > > Sorry to bother you with this, but after reading the thread about the > Eklund papers I'm getting confused about what I actually did when > correcting for multiple comparisons and I'd also like to know whether > I'm on the safe side. > > > I used pre-cashed Monte Carlo simulation with a cluster finding > threshold of 0.05 (at least so I thought): > > mri_glmfit -sim - -glmdir - -cache 1.3 abs - - cache-dir - - > cwpvalthresh 0.01 > > > Am I correct? > This command line will use a voxel-wise threshold of p<.05 (-log10(.05)=1.3) and will report clusters that are significant at p<.01 (rather than the usual p<.05). > > And am I also correct that the FDR may be about 13% instead of 5% when > doing this? > It is hard to say without knowing what the smoothness level is. For my simulations, it was aabout 13%, but this was also thickness data. As you point out the lGI is much smoother. > > (I smoothed thickness and surface area data with FWMH 10mm, but not > the lGI data, because they were already very smooth and pre-cashed > simulation didn't work after additional smoothing). > > > Thanks, Maaike >
-- Douglas N. Greve, Ph.D. MGH-NMR Center gr...@nmr.mgh.harvard.edu Phone Number: 617-724-2358 Fax: 617-726-7422 Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2 www.nmr.mgh.harvard.edu/facility/filedrop/index.html Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/ _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
