Thank you very much Doug!

-----Original Message-----
From: freesurfer-boun...@nmr.mgh.harvard.edu 
[mailto:freesurfer-boun...@nmr.mgh.harvard.edu] On Behalf Of Douglas N Greve
Sent: Friday, November 4, 2016 12:14 PM
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] mris_preproc

projfrac = -2 appears to be pointing at the ventricle. It should be 2*thickness 
away from the white surface into the white matter


On 11/04/2016 12:11 PM, Alshikho, Mohamad J. wrote:
> Hi Doug,
> I am sorry for sending multiple emails. I wanted to be sure that I understand 
> it properly. Kindly:
> My question is regarding "projfrac = -1" and "projfrc=-2" are the pointers in 
> the figure located correctly where the analysis will be carried out?
>
> Thanks again
>
>
>
>
> -----Original Message-----
> From: freesurfer-boun...@nmr.mgh.harvard.edu 
> [mailto:freesurfer-boun...@nmr.mgh.harvard.edu] On Behalf Of Douglas N Greve
> Sent: Friday, November 4, 2016 12:09 PM
> To: freesurfer@nmr.mgh.harvard.edu
> Subject: Re: [Freesurfer] mris_preproc
>
> Do you have a question about the image?
>
>
> On 11/04/2016 11:09 AM, Alshikho, Mohamad J. wrote:
>> Thank you Doug!
>> Kindly in the attached figure are the "projfrac" values for #4 and #5 
>> correct for at which level the analysis will be carried out.
>>
>> -----Original Message-----
>> From: freesurfer-boun...@nmr.mgh.harvard.edu
>> [mailto:freesurfer-boun...@nmr.mgh.harvard.edu] On Behalf Of Douglas N
>> Greve
>> Sent: Friday, November 4, 2016 10:29 AM
>> To: freesurfer@nmr.mgh.harvard.edu
>> Subject: Re: [Freesurfer] mris_preproc
>>
>>
>>
>> On 11/04/2016 07:25 AM, Alshikho, Mohamad J. wrote:
>>>    Dear FS experts,
>>>
>>>    I ran surface based analysis using PET maps, and the pipeline
>>> reported, in FS list, by multiple colleagues as  the following:
>>>
>>> ·spmregister --s subj --mov pet.nii --reg reg.dat --out pet_t1.mgh
>>>
>>> ·mris_preproc --target fsaverage --hemi lh --iv subj1/ubject1_pet.nii
>>> subject1/pet/pet_2_T1_register.dat ..... --projfrac 0.5 --out lh.mgh
>>>
>>> ·mri_surf2surf --hemi lh --s fsaverage --fwhm 6 --cortex --sval
>>> lh.mgh --tval lh.sm6.mgh
>>>
>>> ·mri_glmfit--y lh.sm6.mgh--fsgd fsgd.txt--C 2gc0.mtx --surf fsaverage
>>> lh --cortex --glmdir lh.glmdir//
>>>
>>> ·then mri_glmfit-sim to correct for multiple comparison.
>>>
>>> I wanted to know the correct usage of the flag "*_projfrac_*" in the
>>> command "*_mris_preproc_*":
>>>
>>> My understanding is that this flag control running the surface based
>>> analysis far from the surface (i.e. close to the surface or deep in
>>> the white matter)
>>>
>>> ·If it is 0.5 èthat means the surface based analysis is running in
>>> the middle area between white and pial
>>>
>>> ·if it is zero èthe surface based analysis is running close to white
>>> matter
>>>
>>> ·if it is +1 èthat means the surface based analysis is running close
>>> to the pial
>>>
>>> ·if it is -1 èthat means the surface based analysis is running deep
>>> in the white matter
>>>
>>> Kindly:
>>>
>>> 1.Is this correct?
>>>
>> Yes
>>> 2.Can I  use values like -2 or -3 ... etc to run the analysis deep in
>>> the white matter. I aim to run surface based analysis on multiple
>>> layers of the brain deep from the pial to investigate how the PET
>>> signal is going to change between these layers?
>>>
>> In principle, yes, but often what happens is that when you follow the normal 
>> vector into the white matter that far, you end up in GM or CSF and not WM.
>>> 3.What is the difference between the flag "*_projfrac_*" and the flag
>>> "*_projdis_*"
>>>
>> projdist will project an absolute distance (in mm). projfrac will
>> project a fraction of the thickness (as you describe above)
>>> 4.If I replace the PET maps in the previous pipeline by diffusion
>>> maps? Is it keep valid for diffusion data?
>>>
>> I guess it depends on what you mean by "valid". As I mention above, it
>> will not necessarily sample WM, and that probably invalidates it
>> somewhat
>>> Many Thank!
>>>
>>> Mohamad
>>>
>>>
>>>
>>> _______________________________________________
>>> Freesurfer mailing list
>>> Freesurfer@nmr.mgh.harvard.edu
>>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>> --
>> Douglas N. Greve, Ph.D.
>> MGH-NMR Center
>> gr...@nmr.mgh.harvard.edu
>> Phone Number: 617-724-2358
>> Fax: 617-726-7422
>>
>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
>> FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
>> www.nmr.mgh.harvard.edu/facility/filedrop/index.html
>> Outgoing:
>> ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
>>
>> _______________________________________________
>> Freesurfer mailing list
>> Freesurfer@nmr.mgh.harvard.edu
>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>>
>>
>> _______________________________________________
>> Freesurfer mailing list
>> Freesurfer@nmr.mgh.harvard.edu
>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
>
> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
> www.nmr.mgh.harvard.edu/facility/filedrop/index.html
> Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
>
> _______________________________________________
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>
> _______________________________________________
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>
>

-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
www.nmr.mgh.harvard.edu/facility/filedrop/index.html
Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/

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