sorry, I would use these two

TVV = left lateral ventricle + left inf lateral ventricle + right
lateral ventricle + right inf lateral ventricle + 3rd ventricle
   + 4th   ventricle + 5th ventricle + choroid plexus

TBV = BrainSegVolNotVent

On 04/10/2017 09:43 AM, Gullickson, James wrote:
> Hi Doug,
>
> To clarify: to calculate VBR, I need two things: a measure of TBV 
> /and/ and measure of TVV. I'm just wondering what the best way to 
> derive each of these is.
>
> Thanks,
>
> James
>
> On Fri, Apr 7, 2017 at 11:24 AM, Douglas N Greve 
> <gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>> wrote:
>
>     I would use the TVV
>
>
>     On 04/06/2017 06:28 PM, Gullickson, James wrote:
>     > Doug,
>     >
>     > Thanks for your reply.
>     >
>     > Difference between the two TVV methods ranges between 1-6%
>     > Difference between the two TBV methods ranges between 2-4%
>     >
>     > Basically, my question is two-fold:
>     >
>     > a) what is the most accurate representation of total ventricular
>     volume
>     > b) what is the most accurate representation of total brain
>     volume (all
>     > parenchyma)
>     >
>     > Best,
>     >
>     > James
>     >
>     > On Thu, Apr 6, 2017 at 3:17 PM, Douglas N Greve
>     > <gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>
>     <mailto:gr...@nmr.mgh.harvard.edu
>     <mailto:gr...@nmr.mgh.harvard.edu>>> wrote:
>     >
>     >     that looks right. how different are the values?
>     >
>     >
>     >     On 04/05/2017 10:58 AM, Gullickson, James wrote:
>     >     > Hello all,
>     >     >
>     >     > I want to calculate a Ventricle-to-Brain ratio (VBR) as a
>     measure of
>     >     > parenchymal atrophy using Freesurfer version 5.3.0. I have
>     tried
>     >     to go
>     >     > about this using the aseg.stats output (using
>     asegstats2table),
>     >     but am
>     >     > running into inconsistencies.
>     >     >
>     >     > The basic calculation for VBR is:
>     >     >
>     >     > (Total Ventricular Volume/Total Brain Volume) * 100
>     >     >
>     >     > i.e. Bigler, E. D. (2013). Traumatic brain injury,
>     neuroimaging, and
>     >     > neurodegeneration. /Frontiers in human neuroscience/, /7/,
>     395.
>     >     >
>     >     >
>     >     > What is the best way to get Total Ventricular Volume (TVV)
>     and Total
>     >     > Brain Volume (TBV) for this calculation? I have tried
>     several ways,
>     >     > which lead to different values:
>     >     >
>     >     > TVV = left lateral ventricle + left inf lateral ventricle
>     + right
>     >     > lateral ventricle + right inf lateral ventricle + 3rd
>     ventricle
>     >     + 4th
>     >     > ventricle + 5th ventricle + choroid plexus
>     >     >
>     >     > which gives me a different result than
>     >     >
>     >     > TVV = BrainSegVol - BrainSegVolNotVent
>     >     >
>     >     >
>     >     > and for TBV
>     >     >
>     >     > TBV = TotalGrayVol + CorticalWhiteMatterVol
>     >     >
>     >     > which differs from
>     >     >
>     >     > TBV = BrainSegVolNotVent
>     >     >
>     >     >
>     >     > Thank you for your help,
>     >     >
>     >     > James Gullickson
>     >     >
>     >     >
>     >     >
>     >     >
>     >     >
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>     >     Douglas N. Greve, Ph.D.
>     >     MGH-NMR Center
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>     --
>     Douglas N. Greve, Ph.D.
>     MGH-NMR Center
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
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