Hi Shane
not really - it totally depends on the size of the effect you are looking
for. I would be *very* careful about partial volume effects though
cheers
Bruce
On Fri,
11 Aug 2017, Shane Schofield wrote:
Appreciate it Dr Bruce. Do you have guidelines for smoothing MD?
Dr Yendiki, I am trying to investigate whether cortical MD can be a marker
of neurodegeneration. The idea is that during the early stages of a disease,
cellular microstructure may breakdown before cortical thinning occurs. This
results in "less" barriers against diffusion resulting in an increase of
MD.
On Friday, August 11, 2017, 5:49:40 PM GMT+1, Bruce Fischl
<fis...@nmr.mgh.harvard.edu> wrote:
Hi Shane
you probably don't need cvs as it is more to extend the surface-based
registration to the entire volume. Here you just need the surface-based
registration I believe. Use mri_vol2surf to sample the FA onto the surface.
After that it is identical to a thickness study
cheers
Bruce
On Fri, 11 Aug 2017, Shane Schofield
wrote:
> Thanks Dr Yendiki.
>
> I am more interested to compare MD in grey matter regions by putting the
MD on the surface, and then do a glmfit type of comparisons. Is that OK?
Would you recommend me
> to smooth the data after spatial normalisation? I have also used the
mri_cvs_register as described on the tutorial.
>
>
> On Friday, August 11, 2017, 7:03:49 AM GMT+1, Shane Schofield
<shane.schofi...@yahoo.com> wrote:
>
>
> Hi DTI Experts,
>
> Is it sensible to do comparisons of MD on the cortex surface like a normal
cortical thickness comparisons between group? If the answer is yes, are
there recommended on
> smoothing ?
>
> DT_RECON has been completed in Freesurfer.
>
> Thank you.
>
>
>
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