The surface is created during recon-all. rawfunc2surf-sess resamples the 
volumetric fMRI onto the surface.


On 10/12/2017 01:42 PM, Alissa Stafford wrote:
> Thanks Matt! Does rawfunc2surf-sess create the surface and smooth?
>
> From: <freesurfer-boun...@nmr.mgh.harvard.edu 
> <mailto:freesurfer-boun...@nmr.mgh.harvard.edu>> on behalf of Matt 
> Glasser <m...@ma-tea.com <mailto:m...@ma-tea.com>>
> Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu 
> <mailto:freesurfer@nmr.mgh.harvard.edu>>
> Date: Thursday, October 12, 2017 at 1:39 PM
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu 
> <mailto:freesurfer@nmr.mgh.harvard.edu>>
> Subject: Re: [Freesurfer] volume vs surface-based and surface smoothing
>
> Volume-based registration is fine with subject as you have the same 
> brain that you are registering (ideally such registrations are 6 DOF 
> rigid registrations and any image distortions are corrected for). 
>  Surface-based registration is better when comparing across subjects 
> due to the variability in cortical folding patterns and locations of 
> areas relative to folds across subjects.  Smoothing is best done on 
> the surface if it is done at all.  Smoothing in the volume harms one’s 
> spatial localization precision much more than smoothing on the surface 
> for an equivalent FWMH in mm.  It is worth keeping in mind that 
> smoothing on the surface does still blur across cortical areal 
> boundaries, however, so for many analyses it may be better to average 
> within cortical areas rather than to smooth a lot.
>
> Peace,
>
> Matt.
>
> From: <freesurfer-boun...@nmr.mgh.harvard.edu 
> <mailto:freesurfer-boun...@nmr.mgh.harvard.edu>> on behalf of Alissa 
> Stafford <alissa.staff...@jhu.edu <mailto:alissa.staff...@jhu.edu>>
> Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu 
> <mailto:freesurfer@nmr.mgh.harvard.edu>>
> Date: Thursday, October 12, 2017 at 12:29 PM
> To: "Freesurfer@nmr.mgh.harvard.edu 
> <mailto:Freesurfer@nmr.mgh.harvard.edu>" 
> <Freesurfer@nmr.mgh.harvard.edu <mailto:Freesurfer@nmr.mgh.harvard.edu>>
> Subject: [Freesurfer] volume vs surface-based and surface smoothing
>
> Hello,
>
> I am trying to understand the preprocessing functions to successfully 
> complete surface-based analysis. I am confused about what is happening 
> on the volume level and when exactly the surface is being created. My 
> questions revolve around register-sess and rawfunc2surf-sess.
>
> Registration has 2 parts:
> 1: the native anatomical space is registered with the fsaverage space. 
> This is happening during recon-all.
> 2: native functional data is registered with the native anatomical 
> data. This is happening during register-sess in preprocess-sess.
> Aren’t these both volume-based registrations? If not when are the 
> surfaces created? My concern is that it is volume-based and I was 
> under the impression from this article: 
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862732/ , that all 
> registrations should be done on the surface.
>
> I am also confused about rawfunc2surf-sess. I believe up until this 
> function in preprocess-sess, everything has been done in the volume so 
> this is the first step that is done in the surface, is that correct? 
> And then does this do smoothing? I realized it has a fwhm input option 
> so it must smooth. So is this where the functional data is now 
> expressed in the surface and it also smooths? Or does surfsmooth-sess 
> need to be run in addition to rawfunc2surf-sess?
>
> I basically just want to be making sure I understand when registration 
> is volume-based or surface-based and when it’s appropriate to use 
> volume-based. And I was using the rawfunc2surf function assuming it 
> was for smoothing, but I am not so sure if this only creates the 
> surface or also smooths.
>
> Thanks,
> Alissa
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