Just remove the class.

ps. Please remember to include previous correspondences so we have context


On 4/20/18 6:19 AM, C.P.E. Rollins wrote:
>          External Email - Use Caution
>
> Thanks a lot for the explanation. The issue is that I don't think
> Freesurfer will run a design for which there are no subjects for a given
> class. So if I keep the classes (24 classes since 6 centres x 2 gender x
> 2 groups (patient vs. control), and have the contrast with 12 (-1) and
> 12 (1),
> -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 1 1 1 1 1 1 1 1 1 1 1 1 0
> I get the error:
> --------------------------------
> ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08
> --------------------------------
> Possible problem with experimental design:
> Check for duplicate entries and/or lack of range of
> continuous variables within a class.
>
> I'm assuming this is because there are no participants in, for example,
> patient_centre2_female
> Is there any way to get around this issue, or should I remove those
> centres from my analysis (since I can't only remove
> "patient_centre2_female", as this would make the contrast unbalanced
> (positives and negatives would not add to the same number). I hope this
> was clear but please let me know if it was not.
>
> Thanks again,
> Colleen
>
>
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