yes, because the differences in their morphology don't change the average
very much. You can try it both ways to verify this is true for your
subjects.
cheers
Bruce
On Tue, 19 Feb 2019,
Laboratorio de Neurociencia Funcional wrote:
External Email - Use Caution
Thank, Bruce. So the final message is that I should use the same average
subject to display results
of cortical thickness even when samples to be compared have highly different
brain morphology. Is
that correct?
El lun., 18 feb. 2019 a las 23:37, Bruce Fischl (<fis...@nmr.mgh.harvard.edu>)
escribió:
Hi Jose
usually we don't need multiple averages (or study specific ones), which
simplifies things considerably. Is there a reason you think you need one?
We intentially use the gray/white boundary for this reason, which is
insensitive to any possible cortical atrophy.
cheers
Bruce
On Mon, 18 Feb 2019, Laboratorio de
Neurociencia Funcional wrote:
>
> External Email - Use Caution
>
> Dear all,
>
> I am planning to run separate regression analysis with cortical
thickness in two very
different
> populations (young and elderly subjects). Depending on results, it may
happen that I
am interested
> in comparing regression slopes between the two groups. My question is:
should I build
one average
> subject for each within-group regression analysis (one for young and
another for
elderly), and
> another different average subject merging all subjects of the two
samples to compare
regression
> slopes? Or I should preferably use only one average subjects with all
subjects in all
within and
> between regression analysis?
>
> Many thanks in in advance.
>
> Best regards,
> Jose
>
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