Hi Adam, 

the longitudinal registration should not care, but the regular stream would 
like to have the skull in the image. This will help for a couple steps (full 
head talairach registration -> eTIV etc). 

Best, Martin


> On 5. Jun 2019, at 03:57, Adam Martersteck <acmar...@gmail.com> wrote:
> 
>         External Email - Use Caution        
> 
> 
> Hi Freesurfer team,
> 
> I'm thinking of pre-skullstrip'ing my brains prior to being input into 
> FreeSurfer.
> 
> My fear was this information in the skull might be useful during 
> mri_robust_register or mri_robust_template for longitudinal analyses:
> 
> Martin discusses this in his Freesurfer workshop talk at 9 minutes in 
> (youtube: http://www.youtube.com/watch?v=vxJODPBLd3M&t=9m21s 
> <http://www.youtube.com/watch?v=vxJODPBLd3M&t=9m21s>) where the heatmap 
> covers parts of the skull and the Freesurfer wiki which mentions that the 
> Tukey biweight will deweight regions of noise like tongue/eye/neck 
> differences.
> 
> But it appears the longitudinal stream registers everything on each 
> cross-sectional's norm.mgz to create the fused norm -- which is skullstripped 
> and missing neck/tongue/eyes/skull already.
> 
> Am I missing something? Is it alright if my T1.mgz, rawavg.mgz, orig.mgz, 
> etc. do not have a skull for longitudinal processing?
> 
> Thanks,
> Adam 
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