External Email - Use Caution        

It is the file computed longitudinal processing that represents the rate with 
respect to the thickness at the first time point computed by long_mris_slopes.

Swati




____________________________________________
Swati Rane Levendovszky, PhD
Interim Director, Diagnostic Imaging Sciences Center
Assistant Professor, Integrated Brain Imaging Center
Radiology
University of Washington
Box 357115 | AA035 HSB | Seattle, WA 98195
srle...@uw.edu<mailto:srle...@uw.edu> | Ph: 206 543 6159
Web: https://sites.google.com/site/uwswatirane/
____________________________________________


From: <freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of "Greve, Douglas 
N.,Ph.D." <dgr...@mgh.harvard.edu>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Thursday, January 16, 2020 at 3:26 PM
To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] mri_glmfit-sim for longitudinal pipelines

Sorry, what is "pc1"?
On 1/14/2020 9:44 AM, Swati Rane wrote:

        External Email - Use Caution
Hello,

I was wondering if someone could answer my question below

Can I use mri_glmfit-sim after mri_glmfit on the longitudinal pc1 files.

Are there any set of parameters that should be set differently when using pc1 
instead of thickness files?


Thanks!
Swati



____________________________________________
Swati Rane Levendovszky, PhD
Interim Director,Diagnostic Imaging Sciences Center
Assistant Professor,Integrated Brain Imaging Center
Radiology
University of Washington
Box 357115 | AA035 HSB | Seattle, WA 98195
srle...@uw.edu<mailto:srle...@uw.edu> | Ph: 206 543 6159
Web: https://sites.google.com/site/uwswatirane/
____________________________________________


From: 
<freesurfer-boun...@nmr.mgh.harvard.edu><mailto:freesurfer-boun...@nmr.mgh.harvard.edu>
 on behalf of Swati Rane <srle...@uw.edu><mailto:srle...@uw.edu>
Reply-To: Freesurfer support list 
<freesurfer@nmr.mgh.harvard.edu><mailto:freesurfer@nmr.mgh.harvard.edu>
Date: Friday, January 10, 2020 at 10:06 AM
To: "freesurfer@nmr.mgh.harvard.edu"<mailto:freesurfer@nmr.mgh.harvard.edu> 
<freesurfer@nmr.mgh.harvard.edu><mailto:freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] mri_glmfit-sim for longitudinal pipelines


        External Email - Use Caution
Hello FreeSurfer Developers,

I'm attempting to compare longitudinal cortical thinning rates (pc1) between 3 
groups using mri_glmfit using FreeSurfer 6.0. The tutorial suggests that you 
could use the multiple comparisons corrections that come with it but does not 
comment on using the mri_glmfit-sim option.

I just want to confirm whether there is anything prohibiting me from using 
mri_glmfit-sim. Are there any set of parameters that should be set differently 
when using pc-1 instead of thickness files?

Also, would you do a stricter correction and stick to the longitudinal model or 
prefer the linear mixed effects model and do a FDR? How do you decide between 
the two?

Thanks!
Swati





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