Hi KC
1. Volumes are typically correlated with TIV and so if you don’t care about
TIV itself you probably want to include it as a nuisance variable (both
cortical and subcortical)
2. Thickness does not show this correlation and typically does not need to
be correlated. Surface area does, and so it should be included (possibly to the
2/3 power, perhaps someone else can comment on this?). Not sure about
curvature, but I would assume not as least to first order
Cheers
Bruce
From: freesurfer-boun...@nmr.mgh.harvard.edu
<freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Koustav Chatterjee
Sent: Monday, November 22, 2021 12:03 AM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Requesting to clarify doubts on data analysis
External Email - Use Caution
Dear FreeSurfer team,
I have a few questions to clarify the confusion regarding data analysis.
1. For each subject, is it recommended to normalize the raw volumetric data
by total intracranial volume? If so, is it true only for volumes of
subcortical structures or, both subcortical and cortical structures?
2. In the same way, do I suppose to normalize
* Different cortical thickness with mean cortical thickness
* Cortical surface area with total surface area
* Different cortical curvature with mean cortical curvature
Thank you for your time and help.
Regards,
KC
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