The problem is that your design matrix is badly scaled. The eTIV values are much larger than the group membership (value=1). Try subtracting the mean of the eTIV and dividing by the stddev to normalize it.

On 2/25/2022 8:07 PM, 정현우 wrote:

        External Email - Use Caution

Hi Dr. Greve,

Thank you for your response. I uploaded the .mgh, .fsgd, and .mtx files that I used to run the mri_glmfit command. I can upload the recon-all outputs of the individual samples as well, if needed. The files are uploaded in google drive, please access them via the link below.

*MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be* https://drive.google.com/drive/folders/1QNzMxJdmc7Bo1KGlh9OC9f7DVzZ9ej2k?usp=sharing <https://secure-web.cisco.com/1dyd7-xjzX4Lq_6TpVFINCBx2OzGb31QOy2b8WE4RlFK-rQW7JTWTbadgXYRKAnzQhyfbYr9ZYTmLKlwKzSSQ4tMlXDsMkhJgQ181lHtFxzXgb_Dry1feAP8aKFqOXA1x-F4FuNAsaU8BolN83rf62nnKC8adsct_OhZVZYRMXe1RciKtM0FCMjooYYAmkUm3qRc7PDz8BtLyoRaBXtfZE5nsVlYanmwZSr2cbx0n4upHQjEdEUkJRoX-4GMRt5qLHTNxfJ1mrN8SJ3vMTeBuBdNo8CCqaFKBm3Lb0rAycL-Ir-ihasFHFqKxRhpfCxVCNtXsrjGigkWr7ym9LaK0nw/https%3A%2F%2Fdrive.google.com%2Fdrive%2Ffolders%2F1QNzMxJdmc7Bo1KGlh9OC9f7DVzZ9ej2k%3Fusp%3Dsharing>

Thank you in advance,
Hyunwoo Jeong.



2022년 2월 26일 (토) 오전 8:16, Douglas N. Greve <dgr...@mgh.harvard.edu>님이 작성:

    Can you upload the data to me somewhere? I'd need the input volume
    and the fsgd and any contrasts

    On 2/21/2022 10:24 PM, 정현우 wrote:

            External Email - Use Caution

    Hi Dr. Greve,

    Thank you for your suggestion. Unfortunately, the same problem
    occurred when I ran the command with --no-pcc. Folders and files
    with the same names were created. and the following error message
    (identical to the previous one) appeared.

    error: No such file or directory
    error: MatrixMultiplyD(): m2 is null
     break
    
/home/rd521/space_freesurfer/build/docker_ubuntu18/trunk/rd521-7.2.0/utils/matrix.cpp:596

    Do you have any other suggestions? I appreciate your help so far.

    Best,
    Hyunwoo Jeong

    2022년 2월 17일 (목) 오전 10:18, 정현우 <hwj418...@gmail.com>님이
    작성:

        Hi Dr. Greve,

        Thank you for your suggestion. Unfortunately, the same
        problem occurred when I ran the command with --no-pcc.
        Folders and files with the same names were created. and the
        following error message (identical to the previous one) appeared.

        error: No such file or directory
        error: MatrixMultiplyD(): m2 is null
         break
        
/home/rd521/space_freesurfer/build/docker_ubuntu18/trunk/rd521-7.2.0/utils/matrix.cpp:596

        Do you have any other suggestions? I appreciate your help so far.

        Best,
        Hyunwoo Jeong

        2022년 2월 17일 (목) 오전 1:41, Douglas N. Greve
        <dgr...@mgh.harvard.edu>님이 작성:

            It looks like it is failing when computing the partial
            correlation coef. Try  running it with --no-pcc

            On 2/16/2022 10:53 AM, 정현우 wrote:

                    External Email - Use Caution

            Hi Dr. Greve,

            Yes, it seems like the output folder and some output
            files were created.

            After running the mri_glmfit,
            'three_group_comparison.area.lh.glmdir' folder was
            created. In the glmdir folder,
            'three_group_comparison.area' folder was created, and
            the following files were also created: beta.mgh,
            dof.dat, eres.mgh, fwhm.dat, mask.mgh, mri_glmfit.log,
            rstd.mgh, rvar.mgh, sar1.mgh, surface, and Xg.dat.

            In the 'three_group_comparison.area' folder, the
            following files were created: C.dat, F.mgh, gamma.mgh,
            maxvox.dat, sig.mgh, and z.mgh.

            Do you have any idea what could have been the problem?

            Thanks,
            Hyunwoo Jeong

            2022년 2월 17일 (목) 오전 12:36, Douglas N. Greve
            <dgr...@mgh.harvard.edu>님이 작성:

                Did it create the output folder and some output
                files? I noticed that there is a "error: No such
                file or directory" error ....

                On 2/14/2022 8:46 PM, 정현우 wrote:

                        External Email - Use Caution

                Hi Dr. Greve,

                Thank you for your reply. I attached the fsgd file,
                mtx file and the Xg.dat file below.

                Hyunwoo Jeong

                2022년 2월 15일 (화) 오전 1:21, Douglas N. Greve
                <dgr...@mgh.harvard.edu>님이 작성:

                    can you send your fsgd file and the Xg.dat file?

                    On 2/14/2022 1:21 AM, 정현우 wrote:

                            External Email - Use Caution

                    Hello FreeSurfer Developers,

                    I'm attempting to compare cortical surface
                    area among three groups while controlling for
                    estimated total intracranial volume (eTIV), as
                    described on the Surface Based Group Analysis
                    tutorial (*MailScanner has detected a possible
                    fraud attempt from "secure-web.cisco.com"
                    claiming to be*
                    
https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/GroupAnalysisV6.0
                    
<https://secure-web.cisco.com/1A0QSPCwnovVVVsFNKDP8OXxiBFqZ78jELzRvCgQt7us3rKayy2caTMVKC0nI4ildx0WJqzN5lLz1i-T5FHTbnyaiJAYj3f4mSQ4YHgEnKgBthfsubdAmofQmb_wxbJARZK70-yJh-Q-zB-SO-qUOdB5mSbQ71p0R-muUphnBpsvIZSn12rCp8u9iFutHnHZiR2SHvMYZrtWgA2qG1HwIVF7eXEz_S43Y9x_BasmQivW7O0E14rKYKn2Hc6i1PPi-krEJ-p90KuI4uEnOqU2T3HEQaZ4yicZdxZVpeFkSkL2Taw7LCrmTuBUijdwzR0I8MhzyhVIWFnyo-WUBgBXiig/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Ffswiki%2FFsTutorial%2FGroupAnalysisV6.0>).


                    I ran the following command:

                    mri_glmfit --y
                    three_group_comparison.area.lh.10.mgh --fsgd
                    three_group_comparison.area.fsgd dods --C
                    three_group_comparison.area.mtx --surf
                    fsaverage lh --cortex --glmdir
                    three_group_comparison.area.lh.glmdir --eres-save

                    Then I got the following error:

                    gdfRead(): reading
                    three_group_comparison.area.fsgd
                    INFO: DeMeanFlag keyword not found, DeMeaning
                    will NOT be done.
                    Continuous Variable Means (all subjects)
                    0 eTIV 1.53351e+06 139455
                    Class Size and Means of each Continuous Variable
                    1 0 42 1566070.5417
                    2 1 34 1515147.1360
                    3 2 15 1483959.5000
                    INFO: gd2mtx_method is dods
                    Reading source surface
                    /media/sjkim/hd2/subject_data/fsaverage/surf/lh.white
                    Number of vertices 163842
                    Number of faces    327680
                    Total area 65417.000000
                    AvgVtxArea       0.399269
                    AvgVtxDist       0.721953
                    StdVtxDist       0.195472

                    7.2.0
                    cwd /media/sjkim/hd2/subject_data/glm
                    cmdline mri_glmfit --y
                    three_group_comparison.area.lh.10.mgh --fsgd
                    three_group_comparison.area.fsgd dods --C
                    three_group_comparison.area.mtx --surf
                    fsaverage lh --cortex --glmdir
                    three_group_comparison.area.lh.glmdir --eres-save
                    sysname  Linux
                    hostname sjkim-System-Product-Name
                    machine  x86_64
                    user     sjkim
                    FixVertexAreaFlag = 1
                    UseMaskWithSmoothing     1
                    OneSampleGroupMean 0
                    y
                     
/media/sjkim/hd2/subject_data/glm/three_group_comparison.area.lh.10.mgh
                    logyflag 0
                    usedti  0
                    FSGD three_group_comparison.area.fsgd
                    labelmask
                     
/media/sjkim/hd2/subject_data/fsaverage/label/lh.cortex.label
                    maskinv 0
                    glmdir three_group_comparison.area.lh.glmdir
                    IllCondOK 0
                    ReScaleX 1
                    DoFFx 0
                    Creating output directory
                    three_group_comparison.area.lh.glmdir
                    Loading y from
                    
/media/sjkim/hd2/subject_data/glm/three_group_comparison.area.lh.10.mgh
                       ... done reading.
                    INFO: gd2mtx_method is dods
                    Saving design matrix to
                    three_group_comparison.area.lh.glmdir/Xg.dat
                    Computing normalized matrix
                    Normalized matrix condition is 833.575
                    Matrix condition is 1e+08
                    Found 149955 points in label.
                    Pruning voxels by thr: 1.175494e-38
                    Found 149953 voxels in mask
                    Saving mask to
                    three_group_comparison.area.lh.glmdir/mask.mgh
                    Reshaping mriglm->mask...
                    search space = 74612.059149
                    DOF = 85
                    Starting fit and test
                    Fit completed in 0.0373833 minutes
                    Computing spatial AR1 on surface
                    Residual: ar1mn=0.997826, ar1std=0.000886,
                    gstd=8.674183, fwhm=20.426140
                    Writing results
                    three_group_comparison.area
                        maxvox sig=3.0263  F=7.57212  at  index
                    107440 0 0  seed=1645215319
                    error: No such file or directory
                    error: MatrixMultiplyD(): m2 is null
                     break
                    
/home/rd521/space_freesurfer/build/docker_ubuntu18/trunk/rd521-7.2.0/utils/matrix.cpp:596

                    I used FreeSurfer version 7.2.0 and Ubuntu 20.04.

                    I've searched the mail archives and similar
                    errors have been reported in qdec, but I could
                    not find any specific solution for this
                    problem. Do you have any suggestions to solve
                    this problem?

                    Thank you in advance,

                    Hyunwoo Jeong

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