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Hi Dr Greeve,
I ran recon-all using the flag -flair. I couldn't find any command in
recon-all.log that normalizes the flair images. It seems just normalization
to the T1.
I would like to inquire about the flag sigma in the command "mri_normalize"
the default is 8. when it is recommended to increase this value? and how
much can weincrease it?

I'm not sure of the order. You can run recon-all passing in the flair with
-flair flair.mgz. At some point in the process it will apply a
normalization to the flair (it will not necessarily be the same
normalization that is applied to the t1)




On Mon, Sep 12, 2022 at 4:01 PM James Brown <[email protected]> wrote:

> Dear Freesurfer experts,
> In order to normalize white matter intensity of T1 images and correct for
> bias field. I do the following steps:
> mri_convert T1.nii.gz T1.mgz
> mri_nu_correct.mni --i T1.mgz --o T1_N3.mgz --n 2
> mri_normalize -g 1 T1_N3.mgzT1_norm.mgz
> mri_convert T1_norm.mgz T1_norm.nii.gz
>
> I would like to apply bias field correction on FLAIR images then
> normalize white matter intensity.
> I tried N4biasfieldcorrection from ANTS but it didn't work as expected.
> Reviewing documents about N4biasfieldcorrection I realize that the
> algorithm has been developed to correct bias field correction in T1.
>
> Are the steps above valid for FLAIR images or it can only be applied on T1
> images. We appreciate any feedback about the proper way to correct FLAIR
> images for bias field and normalize white matter intensity.
>
> Thank you
> JamesB
>
>
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