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Dear Amir,

We don’t have a script to make templates, but I don’t think it’d be too hard to 
do it yourself. You can start from eg MNI (not a problem to start from an 
existing atlas since your first iterations will be linear anyway), and use the 
usual procedure:

Initialize A = MNI

For linear_iterations = 1, …, 5

  1.  Linearly register every case to current estimate of A
  2.  Average all registered cases to compute new estimate of A

For nonlinear_iterations = 1, …, 5

  1.  Nonlinearly register every case to current estimate of A
  2.  Average all registered cases to compute new estimate of A

Does this make sense? Even on the CPU, this shouldn’t take more than a few 
hours, depending on how many cases you have.

Cheers,

/Eugenio


--
Juan Eugenio Iglesias
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From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of AmirHussein Abdolalizadeh 
<amirhussei...@gmail.com>
Date: Wednesday, April 26, 2023 at 09:30
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] EasyReg for group-average template?

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Dear Freesurfer users/experts,

I am working on a research project that requires generating group-average 
templates from a large sample of data. I wonder about the possibility of using 
mri_easyreg for generating group-average templates. To my knowledge, the best 
current pipeline is based on using ANTs that 1) do not support GPU, 2) take 
ages to generate a template esp. from a large sample of data. I wanted to know, 
do you have any suggestions to use mri_easyreg for such purposes?

I would greatly appreciate any suggestions or advice you can provide.

Best,
Amir
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