External Email - Use Caution Hi Jan
If you create a family template you will only be able to compare within family, unless you also align the templates I guess? -nonorm will disable z-normalization of curv and sulc. We typically start with a single subject atlas, do a nonlinear (but highly regularized) warp to it, then rebuild the atlas and re-register. We do have a prototype of a more principled procedure but it won't be ready for a few months Cheers Bruce From: freesurfer-boun...@nmr.mgh.harvard.edu <freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Koten, Jan Willem (jan.ko...@uni-graz.at) Sent: Monday, May 8, 2023 8:01 AM To: freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] mris_register options External Email - Use Caution Dear Doug Dear Bruce Martin Reuter suggested me to write you since you are familiar with true inner workings of free surfer. In my project I try to create a family specific template that is based on three or more family members. We try to avoid the bias that may arise by choosing one family member as a target. There is procedure that tries to this described in: MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://secure-web.cisco.com/1IEewrYydOjuYqfmmr7slT8MnQVuTxf5Fupk3DeKFnIOTz1DEFj2XEjEdyBGl0H82UxlCdqEDOvd2EDHAlZHMPFrLfgUiVpijFeEqiemSYey9I4nvk62Ghs7tu2PJB3D_s71OfS1MCH9QDnN1wtgDEOhDxB5QMNr5Z_b6A8aFE3WVMD_08wVNsXG7iSsVyQqNaYynws6DKBeVujNvubb93pSBqcIDoN496yyjtuK-59Y9WSWfgvXyb-MvrrVcK4yB/https%3A%2F%2Ffreesurfer.net%2Ffswiki%2FSurfaceRegAndTemplates<https://secure-web.cisco.com/1Blsa_5fBePXLqTD4MyXB0MVZ8BfrqXwEgfuiFRtv-42VQP34OZ6UZqdfXxQi0tp2V1EoRTro-xOcgb7ClgzFVab407J4Z41cRtu_iJQ7EKKFe0dAvW9s60J_gwqS1U2oxlZRIad20a0m-SEzzq_ngB-95XOOsQpMhOfq6ISgUdxzB8ogeIbf9x0lfc2JgBeXKvf1G9CU7-7m6bSre4_KnhmyXHwl-5_eSx-dnrYxMX7JAnXnHbhmjXzfh_iBpIw7lCaHPbppGijCuVEpwx63sC4TUffSW5dEK1Gxyynbnu8l0ZQdcwiR0kzFZjQvXTtAQikt0tdUkeVQhN8lPE8JlA/https%3A%2F%2Ffreesurfer.net%2Ffswiki%2FSurfaceRegAndTemplates> We found out that family specific templates result in better alignment among family members when compared to the standard fs average template. The creation of a template depends on the mris_register command that has several options that can be manipulated. However, we do not know what those options are doing in detail What is the initial sulcal alignment? Is this a rigid alignment procedure? Maybe a hard spherical rotation based on least squares algorithms? What is the final curve alignment? Is this a non-linear alignment procedure? If sulcal alignment is rigid, why does it take three times as long as non-linear curv alignment? What is normalization in context of mris_register which can be disabled trough the -nonorm step? Does the spring factor affect how much the Individual scul/curv maps are aligned with the family template? And if the latter is the case what is a reasonable spring value if you want to obtain individuals that are as closely matched to the family template as possible? Thank you in Advance Many greetings from Austria Jan
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