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Postdoc position in locus coeruleus connectomics of resilience

at Massachusetts General Hospital / Harvard Medical School

The Gordon Center for Medical Imaging (GCMI) in the Department of Radiology at 
Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) in 
Boston, Massachusetts, has an opening for highly qualified individuals at the 
post-doctoral level to work with Dr. Heidi Jacobs and Dr. Sepulcre. The Jacobs 
lab is part of the Gordon Center for Medical Imaging at MGH and focused on 
improving the early detection and early treatment of Alzheimer’s disease. The 
lab focuses on the neuromodulatory subcortical nuclei, in particular the locus 
coeruleus, using a variety of approaches, including 7T MRI, PET imaging, pupil 
measurements, physiological recording, blood-based markers, cognitive 
assessments and non-invasive vagus nerve stimulation. The Sepulcre lab is 
focused on connectomics, brain organization methods and the integration with 
genomics in neurodegenerative diseases. This project is focused on identifying 
locus coeruleus functional network properties conferring resilience against 
Alzheimer’s disease-cognitive decline in the face of pathology and identifying 
network properties indicating risk of Alzheimer’s disease. This project will 
require pulling and harmonizing large imaging datasets together to investigate 
locus coeruleus function across the disease continuum (e.g. ADNI, HABS, A4, 7T 
lifespan dataset,..). The Jacobs Lab consists of a multidisciplinary team of 
one instructor, five postdocs, three PhD-students, three clinical research 
coordinators and one project manager. The Sepulcre lab consists of one 
Assistant Professor, three postdocs and several students.

Most of the work in this project will be performed at the Athinoula A. Martinos 
Center for Biomedical Imaging, Charlestown Navy Yard. The candidate will be 
part of ongoing collaborations and be able to work in a stimulating and 
inspiring environment. The Department of Radiology at MGH is equipped with the 
first mobile PET/CT, the first brain PET/MRI, the first whole-body PET/MRI in 
the USA and several MRI scanners, including two 7T ultra-high-field scanner. It 
is equipped with a large-scale shared memory computing facility for parametric 
image analysis, tomographic reconstruction, Monte Carlo simulation, and other 
computationally intensive research applications.

Our research group values open communication, motivation, optimism, mutual 
respect, teamwork, and innovative thinking. Dr. Jacobs and Dr. Sepulcre are 
highly committed to individualized mentoring to help trainees achieve the most 
out of their postdoctoral candidature and to move forward in their career. At a 
minimum, the training environment will include professional development, 
one-on-one meetings, group lab meetings, frequent seminars and journal clubs, 
opportunities to present their work at national and international scientific 
conferences (i.e. Human Amyloid Imaging, Alzheimer’s Association International 
Conference, OHBM), collaboration with partners within and outside MGH, and 
manuscript preparation for publication in high impact journals. In addition, 
both Dr. Jacobs and Dr. Sepulcre have a strong funding record and will strongly 
encourage and provide mentorship in grant applications.



Requirements: Candidates should have a Ph.D. in Cognitive Neuroscience, 
Computational Neuroscience, Neuroimaging, Psychology (Biological) or related 
disciplines. Strong analytical, quantitative and programming skills and 
experience in fMRI are essential. Experience in connectomics or graph theory 
and physiological modeling would be beneficial. The candidate should be highly 
motivated, a strong communicator, possess internal drive to learn 
independently, but also be comfortable with working as part of a larger 
collaborative team. A real necessity is a passion for science, strong 
scientific writing and organizational skills, and a positive attitude. 
Experience in Alzheimer’s disease dementia or aging would be beneficial.

[cid:image001.png@01D9C144.C546D1F0]MGH & HMS are equal-opportunity, 
affirmative action employers. Women and minority candidates are encouraged to 
apply.



[cid:image002.png@01D9C144.C546D1F0]Apply: The successful candidate will have 
joint appointments at MGH and HMS. If interested, please send your CV, letter 
describing interests, background, major achievements, skills, goals and contact 
information for three professional references. Please send application 
materials to Dr. Heidi Jacobs, Associate Professor of Radiology, at 
hjac...@mgh.harvard.edu<mailto:hjac...@mgh.harvard.edu>








Dr. Heidi Jacobs
Associate Professor of Radiology

Massachusetts General Hospital
Harvard Medical School
Department of Radiology
Gordon Center for Medical Imaging
149 13th Street
Charlestown, MA 02129
hjac...@mgh.harvard.edu
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