yes, it is the same contrast
On 11/20/2023 3:30 PM, Laura Willers de Souza wrote:
External Email - Use Caution
Great, thanks so much!
But I am having difficulty understanding how to construct the contrast
to answer the following question "Is the interaction between group
(CU/CI) and cortisol significant regressing out the effect of sex,
age, APOE_carrier, abeta and ptau?" It seems like the contrast would
be the same as before.. Can you help me with this?
Thanks again!
*Laura Willers de Souza *
PhD Student in Pharmacology and Therapeutics
Zimmer Lab - Federal University of Rio Grande do Sul
- Porto Alegre/RS - Brazil
-----
Douglas N. Greve
<https://secure-web.cisco.com/1yYgRLzmOCtuh8UFLaxt4ucohab6Ii9cqIDNXc9_tUgQITTp1lOWVlAhzXYGkoInMWkZJnqBum7Q2bchzciGSB2Na5ppT64MdUHXfn7DI7OxVbl4tT_fQgG0kh4IlbeSX880ZgCJICom9qj1NBstIOI_qjcTChjXuR3dPdszFYItn-gVUJfGCKXlG9o7fhLWguzZ50_ydhnvD4rOrLoYLiBMx5Nmfxu8b5Qmskd6WJN4ex-Jbo86HQs-OZhybUtFxJTLMjaMs7VA2KehPsIkWC3mSNsPAK9OmfLQGqixmeiXleO-ZWJPtFvWKnaHcn4WLC4dwagoumvUqRgC7u1xm6-Cyydvyaps-m9D_aFSH-mc/https%3A%2F%2Fwww.mail-archive.com%2Fsearch%3Fl%3Dfreesurfer%40nmr.mgh.harvard.edu%26q%3Dfrom%3A%2522Douglas%2BN.%2BGreve%2522>
Wed, 15 Nov 2023 06:54:36 -0800
<https://secure-web.cisco.com/1YP7c0yUfORmuLGAmHVodnKa9al2_Y0u_TMgwZ8HHpNLBopCps66WL5fi8BIQOtGT2EIe686Cb-kKvvGhRCe4_SaK0WJ3KOn4c9Sj2WdQqojkvfBeHT3N0kEtpp4XZYzhlfT_eJ5jkScsByN1WqEs3tHZcGwdZjDYiA2VHhgtKgDSnuHH09-N9wy-MRx6r58e_5aLN4OM9T2RKO6OnJ5mx8nK9pUHOSr26E4tD08yymXHHwjtsv4xTNRM0PO-47K6TZb26i11we8tVt1lnats3dUctrHhexXc9YvBQKMu_pUzZw2Ma-p89k7jGVEZBbCbg5alwGGg9GzThW3Fv1_YxTcKTYDjh20IrtgY3QjPvlU/https%3A%2F%2Fwww.mail-archive.com%2Fsearch%3Fl%3Dfreesurfer%40nmr.mgh.harvard.edu%26q%3Ddate%3A20231115>
Yes, that looks right (assuming that cortisol is your first variable)
---- On 11/7/2023 3:49 PM, Laura Willers de Souza wrote:
External Email - Use Caution Hello FreeSurfer Developers,
Following the FSGD examples on the website, I built the following test:
Question: Is there an association between cortisol and cortical
thickness regressing out the effect of sex, age, APOE4_carrier (1=1 or
2 alleles, 0=no alleles), abeta, ptau, diagnosis (CU and CI)?
Regressors: 2 factors (sex, diagnosis) with 2 levels each, 5
covariates (age, APOE4_carrier (1=1 or 2 alleles, 0=no alleles),
abeta, ptau, cortisol) >> 24 regressors
Contrast: 0 0 0 0 0.5 -0.5 0.5 -0.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
FSGD: GroupDescriptorFile 1 Title CSF_semgrupos Class MaleCU Class
MaleCI Class FemaleCU Class FemaleCI Variables Cortisol Age ABETA ptau
APOE4_carrier Input 098_S_4003_I224603 MaleCI 11 81.3 741.5 22.83 1
Does this feel right to you?
I am having difficulty understanding how to construct the contrast to
answer the following question "Is the interaction between group
(CU/CI) and cortisol significant regressing out the effect of sex,
age, APOE_carrier, abeta and ptau?" It seems like the contrast would
be the same as before.. Can you guys help me with this?
Thanks in advance! *Laura Willers de Souza * PhD Student in
Pharmacology and Therapeutics Zimmer Lab - Federal University of Rio
Grande do Sul - Porto Alegre/RS - Brazil
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Mass General Brigham
Compliance HelpLine at https://www.massgeneralbrigham.org/complianceline
<https://www.massgeneralbrigham.org/complianceline> .
Please note that this e-mail is not secure (encrypted). If you do not wish to
continue communication over unencrypted e-mail, please notify the sender of
this message immediately. Continuing to send or respond to e-mail after
receiving this message means you understand and accept this risk and wish to
continue to communicate over unencrypted e-mail.