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Hi Doug,

Sorry for not elaborating in my previous email.

Voxel lesion symptom mapping (VLSM) is a method to calculate symptom
localization by estimating statistical relationships between damage to
specific brain regions (it could be stroke lesion, tumor lesion or TBI
lesion etc.) and resulting deficits (e.g.,
https://secure-web.cisco.com/1UiWVbssc136ehHR7fbKC3mJg7kJQVmdWhaRoU7E29vpu5yNgNVpd0lZiq4aR019jbUXsgd9ifhWAi0IlkNaX6x9xio5om5mkSpOTNvua1cW-cEEjvzxDi3L2sB29VZVsnhEZ8Tb3UH9P0xee7U6UR5dzGEOh8QJNPNhtL65F1jvipA-Phq6I6tlLdM_es5V3bNy-Uc2GG6yXw2BY9-tSYOxCFzZ8xvUgiqlPE8H6y5TPAXxx9g0S5ELQ2MYBhZc4scdk6uSlw8_4_qsmFzE3pHqfDGZ0Q_Jv3szY1k1AqHkxkI9t7LPh8R6dSgTpNeL4WUyRopXxirT8r-0IxK7nYA/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4724038%2F
 and
https://secure-web.cisco.com/1Sv3DQt7ECt7yYskA3qSYiurVnqwYgQMrW8bVWoluBQmsM_yLtTYU5rsNedrt7kfxvXWRFNBdsUI4A1g3RXw72SMBIG6ZQrrv9cyiZQGDsnk8bidCzCK_lFen7x0alY7ZhJs5O1HBwG06GFvTNxoPfkbR1hD87w8QzlmPBxoAV_migSoy78DKyb73PilyF7D9vRCcWNAx4UOdo0SSrO_Shf1_py0ygzhtUB2FOJo-0Z-5e1wnn3cKO0-MJMcDUhRdVzUXTYWyey2rVOBEqbKBye_yDzoaxLIKzESNFAVFJGY8t8AlAjZS0kE9aqzZKXXtHqmihL1X2aNJDuA_eQsRZA/https%3A%2F%2Facademic.oup.com%2Fbrain%2Farticle%2F137%2F9%2F2532%2F2848278).
 This method can
guide the development of targeted interventions and rehabilitation
strategies aimed at improving symptoms by targeting specific brain regions
(or networks, if we use network lesion symptom mapping:
https://secure-web.cisco.com/10LgUitf4Y4lehNjHOInoyAOPPrjXpKyw8QudhBNFrI-HEs531siCcOCZApchqgDvWDYKy7cM6QODz-i1dQPhiBuCX-00bXDcm2EF8XZrhB_Rknetjx1FVS8u1BBOZ16mMYnGswaNPzNgbt15-7OR0ZajBrz3jJMaAXx2tGeFbJuIT_cwpTPX2u7uVcKu40byzK3CksUD9sBXUODMzo1dWFYJ7dqv9jzjPyhXiM51d49k7iGamx_SlWvcrdjka0R328JXdXbqwiXqt2FEwAVsz1ioBdFbSPNdth73sqgmm1hDt5vQsBMMp8Txr8bGJeZxE6q-ZHf8yqwxiFsXOOVtBw/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9724189%2F).

On Fri, Feb 23, 2024 at 10:27 AM Douglas N. Greve <dgr...@mgh.harvard.edu>
wrote:

> Sorry, don't know what VLSM is. Can you elaborate?
>
> On 2/6/2024 3:19 PM, Martin Juneja wrote:
>
>         External Email - Use Caution
> Dear FreeSurfer community and experts,
>
> I would greatly appreciate any help/response with the following.
>
> Thanks.
>
> ---------- Forwarded message ---------
> From: Martin Juneja <mj70...@gmail.com>
> Date: Wed, Jan 31, 2024 at 7:51 PM
> Subject: Vertex / voxel lesion symptom mapping
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>
>
> Greetings FreeSurfer community,
>
> I was just wondering if it's possible to perform vertex/voxel lesion
> symptom mapping (VLSM) using FreeSurfer? In other words, I would like to
> assess the impact of lesion topography (of course, heterogenous locations
> across patients) on neurocognitive function in brain tumor patients.
>
> I would greatly appreciate any help/response.
>
> Thanks!
>
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