Hi Dan,

Also for 1 random effect you probably have a benefit using the region approach 
rather than vertex wise.

Best, Martin


On 25. Jun 2024, at 17:47, Dan Levitas <djlevitas...@gmail.com> wrote:

Hello,

I've been analyzing a dataset consisting of two groups (control, clinical), 
each with two timepoints (tp1, tp2), following FreeSurfer's LME longitudinal 
analysis pipeline, to assess cortical thickness differences.

Given the relative simplicity of my data, I've only specified a single random 
effect (intercept). In the FreeSurfer section on spatiotemporal models, it 
begins with "Spatiotemporal models are more powerful to detect effects in your 
data than traditional vertex-wise models when two or more random effects are 
included in the longitudinal statistical model." However, I've currently been 
using the spatiotemporal model approach (lme_mass_fit_EMinit, lme_mass_RgGrow, 
lme_mass_fit_Rgw) with the single random effect, but am curious if this is 
inappropriate and instead need to use the mass-univariate (lme_mass_fit_vw) 
workflow?

Dan
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
The information in this e-mail is intended only for the person to whom it is 
addressed.  If you believe this e-mail was sent to you in error and the e-mail 
contains patient information, please contact the Mass General Brigham 
Compliance HelpLine at https://www.massgeneralbrigham.org/complianceline 
<https://www.massgeneralbrigham.org/complianceline> .
Please note that this e-mail is not secure (encrypted).  If you do not wish to 
continue communication over unencrypted e-mail, please notify the sender of 
this message immediately.  Continuing to send or respond to e-mail after 
receiving this message means you understand and accept this risk and wish to 
continue to communicate over unencrypted e-mail. 

Reply via email to