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Dear Douglas,

I am sorry for the late response. I did not see your message up until now.
I would like to see how the brain changes for a patient with anxiety
who got better gradually (again, we have 5-time points (0, 3, 6, 9,
12). And then do the same for another participant who did not get
better up until 12 months.
That is the reason I would like to look at patients one by one.

I ran the mri_glmfit analysis but I received an error message:

 ERROR: DOF=0

Is this because I tried to run it on one participant?

Sincerely,
Isa Rosselini

Date: Mon, 3 Feb 2025 09:20:40 -0500
From: "Douglas N. Greve" <[email protected]>
Subject: Re: [Freesurfer] longitudinal analysis on one subject
To: [email protected]
Message-ID: <[email protected]>
Content-Type: text/plain; charset="utf-8"

The glm can be run on this data in theory. With only 5 time points, you
probably won't have much power though. What are you trying to test?

On Sat, Feb 1, 2025 at 11:56 PM Isabella Rossellini
<[email protected]> wrote:
>
> Hello Freesurfer users/experts,
>
> I am working with Freesurfer 7.4.1 on a MacStudio (macOS 15.2) and I would 
> like to ask your opinion about the following.
>
> Basically, we had an anxiety treatment study and I would like to analyze one 
> subject who has 5-time points (0, 3, 6, 9, 12) with a longitudinal pipeline, 
> two-stage model.
> Is it possible to run this on one person only and see the changes between 
> these time points?
>
> I have never done this before on one subject so I am not sure what the best 
> approach would be to look at the changes.
> After running the longitudinal preprocessing (base, long), should I generate 
> the tables of freesurfer parcellation/segmentation stats data
> (aparcstats2table, asegstats2table)?
> Or can I just follow the two stage model steps? Maybe glm only works on a 
> group of subjects.
> https://secure-web.cisco.com/1RCkpkv-7j7POY3iFHgRmXEUWgfCzKlqbBUGWLnc2RlZdY5nRKqE-Tyb58jPc7L5ZPOCj6Wk4FkzBnwiIVrHsBykQRm-l3Jn-ZMspfbCqLAWIrq78XF02rbouW2bUaQWQNyt7YSwswKJilktqReJF5U1Df5Vr3t2cMRnUzqQLCxsS8m1HXvZ131aAEwaFpFcRjH7wSODHJcqJ6YZa9avlKQ_jV6v0vzL-YLQKMIh0TQ8l5U9AvXEtxA3wt-JqnjnWCnYOTs0hem1ZdTHwx61ND4OhpBsVvE3WulFdmyCEXSNxDeIjuj_Ox30tQ-CZXxiEPu7qmKWNnFc710luNzkSnQ/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Ffswiki%2FLongitudinalTwoStageModel
>
> (We have 9 more subjects - 10 in total - so I was hoping to visualize the 
> pattern of changes one by one, in each subject, since these patients showed 
> different changes in anxiety based on self-reported
> questionnaires)
>
> Sincerely,
> Isa Rosselini
>

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