Not exactly because volumes are computed from soft segmentations rather than discrete labels, but yeah, it should be very close.
-- Juan Eugenio Iglesias http://www.jeiglesias.com From: Marco Ganzetti <marco.ganze...@biogen.com> Date: Tuesday, July 1, 2025 at 3:55 AM To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu> Subject: [Freesurfer] Re: eTIV in SynthSeg External Email - Use Caution Thanks. In SynthSeg, if I set a threshold at 0.5 on the segmentation output, should I get exactly the TIV? Label 0 is the background, therefore all the labels above 0 should constitute the TIV. Is this the case? Best, Marco From: Iglesias Gonzalez, Juan E. <jiglesiasgonza...@mgh.harvard.edu> Date: Tuesday, 1 July 2025 at 05:51 To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu> Subject: [Freesurfer] Re: eTIV in SynthSeg EXTERNAL SENDER The former! -- Juan Eugenio Iglesias http://www.jeiglesias.com From: Marco Ganzetti <marco.ganze...@biogen.com> Date: Monday, June 30, 2025 at 05:57 To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu> Subject: [Freesurfer] eTIV in SynthSeg External Email - Use Caution Dear, I would like to know how the eTIV is estimated in SynthSeg and SynthSeg+ . Is it a combination of CSF+ventricles+WM+GM masks? Or do you estimate is using the registration to MNI space approach? Best, Marco
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