Hi Marco,
We’ve built a wrapper method around it. We just got it published but haven’t 
found the time to make it easily usable (also, the first author is on leave…). 
But we’ll get there 😊
https://www.sciencedirect.com/science/article/pii/S1361841525002099
Cheers,
/Eugenio

--
Juan Eugenio Iglesias
http://www.jeiglesias.com

From: Marco Ganzetti <[email protected]>
Date: Tuesday, July 1, 2025 at 11:31 AM
To: [email protected] <[email protected]>
Subject: [Freesurfer] Measuring longitudinal changes in brain volume using 
SynthSeg

        External Email - Use Caution
Does SynthSeg offer any functionality for estimating longitudinal changes in 
segmented brain volumes beyond simply subtracting values from two time points?
Marco
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