Kelly,

>
> > What NIC do you happen to be using?
>
> These machines were the Intel ISP series, the use the Inteal 82559 Fast
> Ethernet Lan on Motherboard
>

Ensure that you have turned off all power management for the NIC Card.
Ensure that you have the latest drivers for this card.
http://downloadfinder.intel.com/scripts-df/filter_results.asp?strOSs=24&strT
ypes=PLU%2CDRV%2CARC%2CSPH%2CUTL&ProductID=60&OSFullName=Windows+NT*+4.0&sub
mit=Go%21

> > Any large mailboxes?
>
> Of course.  Is Imail only good for small mailboxes with the upgrade?
>
IMail is just that.. 'EMail' I can not emphise this enough with our users.
We don't offer 'file' storage.  50 megs, our limit, is insane - yet we have
people complain.

I seem to recall that there is a 'speed' increase 'work around' that is
needed if you use the Killer Web Templates.  Check the install instructions
for the proceedures.  I think it's primarily intended for web access though
but it'll probably lighten the load off the cpu.

> > When was the last defrag done?
>
> How do you defrag a highly active mail server with 1000s of users?  I did
> create a new empty spool directory on a newly formatted partition on a
> separate drive.
>

I'm not generating near the capacity that you are, for email, but would
venture to say that one might select a time of low usage to perform
'necessary' defrags.  If you are limited on ram < 256 megs then I'd think a
mem upgrade should/would help.  If your cpu is < 400 Mhz then you might
consider an upgrade.  If your fsb is only 66 mhz.. then again.. upgrade.

> > Have you triple checked all TCP/IP settings on the server?
>
> They are the same ones I've been using for 5 years, checked thrice twice.
>
> > Is this a standalone server or a DC?
>
> Stand Alone
>

You might try adjusting your memory management and enable to Maximize
Throughput For Network Applications.
Any other applications running on this server that possibly could interfer
with networking or platform capablities. SQL 6.5?  Anti-Virus apps?

> > Any odd files in the spool directory?
>
> Not in the new one...   Maybe I'm holding my mouth wrong?
>
> I take it from the "here we go again" comment that this is a typical
problem
> for users upgraded.  Maybe the product just sucks?
>

IMail 7.x has some very 'small' issues, none of which is identifiable from
your concerns, but over all is a great product.

~Rick

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