Dear All, I am analyzing a data set pooled from 4 clinical studies with rich sampling. When I fit a 2 comp oral absorption model with lag time using FO, I got successful minimization with COV step, but minimization was not successful when I used FO parameter estimates as initial estimates for FOCE run. When I used FOCE with INTER minimization was successful with COV step but the OFV is much higher (~25000 vs 20000) with FOCEI estimation than FO. The parameter estimates make more sense with FOCEI than FO. My questions are,
Can we get something like this or I am missing something here? Can we compare OFV between different estimation methods (my understanding is no and OFV in case of FO does not make a lot of sense)? Regards, Ayyappa Chaturvedula GlaxoSmithKline 1500 Littleton Road, Parsippany, NJ 07054 Ph:9738892200
