Pavel: Try using the latest nonmem 7.3 version if you can, and see if this still occurs. Improvements are continually being made. Try also the following after an SAEM step:
$EST METHOD=IMP EONLY=1 MAPITER=0 (...plus other options as neded) Or $EST METHOD=IMPMAP EONLY=1 (...plus other options as needed) Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.iconplc.com -----Original Message----- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Pavel Belo Sent: Thursday, May 15, 2014 11:02 AM To: nmusers@globomaxnm.com Subject: [NMusers] SAEM and IMP Hello NONMEM Users, As SAEM does not provide a useful objective function, the manuals recommend using IMP after SAEM. It works well in many cases when IMP works well. When IMP works well, SAEM is not always needed. SAEM is really needed when the other methods do not work well. The issue is that there are hard cases when SAEM works very well and IMP does not work at all. SAEM provides meaningful and consistent PK/PD parameters across very different runs, while IMP provides objective function, which varies so greatly that it looks meaningless. Another potential issue with IMP is that even when it works well with a problem, it occasionally provides low values of objective functions after SAEM or as the first estimate (less frequently in the middle of IMP run) and then becomes unstable or jumps to much higher objective function and then converges to something between the low and the high values for a long time. It almost looks like IMP does not show some kind of integration/computation errors and keeps running providing a funny objective function. It seems like we cannot estimate objective function when SAEM runs well and IMP does not. It reduces the value of SAEM. Is there a way around it? Thanks, Pavel <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
