If your theta=SD’s will have etas, no need for TS() specification. You should not need to put in the GRD statement at all, then. (The TG() is to force Gibbs sampling in BAYES methods)
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics R&D ICON Early Phase Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Pavel Belo Sent: Friday, November 20, 2015 12:31 PM To: nmusers@globomaxnm.com Subject: [NMusers] mu coding for variability in SD Hello The NONMEM Professionals, The model requires SAEM. Is mu coding useful when each subject has to have different SD (SDi=SD0*exp(etai))? It may look something like MU_8 =THETA(8) SD = DEXP(MU_8 +ETA(8)) $THETA (0.00001,0.0413,50) ;SD1 $THETA (0.001 FIX) ;SD2 GRD=TG(1-9) ;(instead of GRD=TG(1-7):TS(8-9)) Thanks! Pavel <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
