Bill: The straight substitutions should work for any variable. Alison and I discovered a minor glitch in nm74 (it works okay in nm73), where substitution does not occur if there is a space between the name and the = sign in the execution statement. So, instead of
FCMTD1GUT = THETA(1) try FCMTD1GUT= THETA(1) and see if that works. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: William Denney [mailto:wden...@humanpredictions.com] Sent: Wednesday, January 24, 2018 4:08 AM To: Bauer, Robert Cc: Luann Phillips; nmusers Subject: Re: [NMusers] $ABBR REPLACE Limitations? Hi Bob, Thanks for this confirmation. I'm using 7.4.1. For my other question, is there a limitation of $ABBR REPLACE which prevents its use for parameters like F1 and ALAG1? Thanks, Bill On Jan 24, 2018, at 00:43, Bauer, Robert <robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com>> wrote: This bug has been fixed since NONMEM 7.4 Bug #1, nm730_bug_list.pdf in https://nonmem.iconplc.com/nonmem730<https://nonmem.iconplc.com/nonmem730> Two variables with names longer than six characters, and identical in the first six characters, defined in $PK, and used in $DES, will be seen as the same variable. Use variable names that differ in the first six characters. This occurs in NONMEM 7.1.0, 7.1.2, 7.2.0, and 7.3.0. A workaround is to move all assignment statements for variables whose first 6 characters match to $DES. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Bill Denney Sent: Tuesday, January 23, 2018 4:40 PM To: Luann Phillips Cc: nmusers Subject: RE: [NMusers] $ABBR REPLACE Limitations? Hi Luann, I’m not having similar problems with other parameters with >6 characters. I had a similar issue with ALAG1, so I think that there are limitations on what types of variables you can remap. (Perhaps Allison or Bob could confirm?) Thanks, Bill From: Luann Phillips [mailto:lu...@cognigencorp.com<mailto:lu...@cognigencorp.com>] Sent: Tuesday, January 23, 2018 3:51 PM To: Bill Denney <wden...@humanpredictions.com<mailto:wden...@humanpredictions.com>> Cc: nmusers <nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com>> Subject: Re: [NMusers] $ABBR REPLACE Limitations? Bill, I know at one time NM had a bug (haven't checked to see if it has been fixed) that would cause variables with the first 6 characters the same to be interpreted as the same variable even when later characters differed. I wonder if this is a similar issue? Have you tried a shorter variable name, such as FCD1GUT=F1? Just a thought, Luann ________________________________ From: "Bill Denney" <wden...@humanpredictions.com<mailto:wden...@humanpredictions.com>> To: "nmusers" <nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com>> Sent: Tuesday, January 23, 2018 2:15:32 PM Subject: [NMusers] $ABBR REPLACE Limitations? Hi, I’m working in NONMEM 7.4.1 with a model where I need to track 4 drugs simultaneously. To increase the model quality, I’m making heavy use of $ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an issue with my model where there was no gradient on a bioavailability term to the fact that this substitution didn’t seem to be working: $ABBR REPLACE FCMTD1GUT=F1 … $PK … FCMTD1GUT = THETA(1) FCMTD1GUT didn’t seem to be effectively replaced to F1, so the bioavailability parameters had no effect. When I changed it to just directly name F1, it worked as expected. $PK … F1 = THETA(1) It’s not obvious from the $ABBR REPLACE section of the manual that this is a limitation of $ABBR REPLACE. Is this an issue or am I missing something? Thanks, Bill ________________________________ <image001.jpg><http://www.humanpredictions.com/>William S. 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