Hi Nick, I'll take a look.
Thanks, Bill > On Jan 24, 2018, at 02:59, Nick Holford <n.holf...@auckland.ac.nz> wrote: > > Bill, > > An alternative, and IMHO more convenient, method of coding parameters, > written as THETA, ETA and EPS/ERR indexed variables, is to use the ntcs.awk > script provided as part of Wings for NONMEM. <http://wfn.sourceforge.net/> I > developed WFN in 1990 and one its primary aims was to allow the user to code > these variables as meaningful user defined names and stop having to count > vector indices. > > ntcs.awk is an awk script that can be used on any platform that can run awk > (all NONMEM platforms as far as I know). You can use arbitrarily long names > for your parameters as long as they are unique. > > It should just be one line added to any script you currently use with > standard NM-TRAN. You don't have to use any other part of WFN. You can then > forgot about counting the parameter vector index and having to redo > everything if you change the order parameters or insert parameters. > > Best wishes, > > Nick > > >> On 24-Jan-18 13:40, Bill Denney wrote: >> >> Hi Luann, >> >> I’m not having similar problems with other parameters with >6 characters. I >> had a similar issue with ALAG1, so I think that there are limitations on >> what types of variables you can remap. (Perhaps Allison or Bob could >> confirm?) >> >> Thanks, >> >> Bill >> >> *From:* Luann Phillips [mailto:lu...@cognigencorp.com >> <mailto:lu...@cognigencorp.com>] >> *Sent:* Tuesday, January 23, 2018 3:51 PM >> *To:* Bill Denney <wden...@humanpredictions.com >> <mailto:wden...@humanpredictions.com>> >> *Cc:* nmusers <nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>> >> *Subject:* Re: [NMusers] $ABBR REPLACE Limitations? >> >> Bill, >> >> I know at one time NM had a bug (haven't checked to see if it has been >> fixed) that would cause variables with the first 6 characters the same to be >> interpreted as the same variable even when later characters differed. I >> wonder if this is a similar issue? >> >> Have you tried a shorter variable name, such as FCD1GUT=F1? >> >> Just a thought, >> >> Luann >> >> ------------------------------------------------------------------------ >> >> *From: *"Bill Denney" <wden...@humanpredictions.com >> <mailto:wden...@humanpredictions.com>> >> *To: *"nmusers" <nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>> >> *Sent: *Tuesday, January 23, 2018 2:15:32 PM >> *Subject: *[NMusers] $ABBR REPLACE Limitations? >> >> Hi, >> >> I’m working in NONMEM 7.4.1 with a model where I need to track 4 drugs >> simultaneously. To increase the model quality, I’m making heavy use of >> $ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an >> issue with my model where there was no gradient on a bioavailability term to >> the fact that this substitution didn’t seem to be working: >> >> $ABBR REPLACE FCMTD1GUT=F1 >> >> … >> >> $PK >> >> … >> >> FCMTD1GUT = THETA(1) >> >> FCMTD1GUT didn’t seem to be effectively replaced to F1, so the >> bioavailability parameters had no effect. When I changed it to just >> directly name F1, it worked as expected. >> >> $PK >> >> … >> >> F1 = THETA(1) >> >> It’s not obvious from the $ABBR REPLACE section of the manual that this is a >> limitation of $ABBR REPLACE. Is this an issue or am I missing something? >> >> Thanks, >> >> Bill >> >> ------------------------------------------------------------------------ >> >> Human Predictions Logo <http://www.humanpredictions.com/>*William S. Denney, >> PhD* >> Chief Scientist, Human Predictions LLC >> +1-617-899-8123 >> wden...@humanpredictions.com <mailto:wden...@humanpredictions.com> >> >> This e-mail communication is confidential and is intended only for the >> individual(s) or entity named above and others who have been specifically >> authorized to receive it. If you are not the intended recipient, please do >> not read, copy, use or disclose the contents of this communication to >> others. Please notify the sender that you have received this e-mail in error >> by replying to the e-mail or by calling +1-617-899-8123. Please then delete >> the e-mail and any copies of it. Thank you. > > -- > Nick Holford, Professor Clinical Pharmacology > Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A > University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand > office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 > email: n.holf...@auckland.ac.nz > http://holford.fmhs.auckland.ac.nz/ > http://orcid.org/0000-0002-4031-2514 > Read the question, answer the question, attempt all questions > >
