Joe Acquisto-j4:
> Currently have postifx configured to relay mail via a "relay_host"
> (main.cf).   There is a need to send mail to a certain domain via
> a different host.   Google has suggested a few ways, transport
> hash, header filter.
>
> Since this special destination has a primary and a secondary IP,
> how might I specify more than one IP for this "custom" domain?

With multiple address records in DNS or /etc/hosts.  See also:
http://www.postfix.org/postconf.5.html#smtp_host_lookup

        Wietse

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