Well, I am woefully unqualified to speak to the general state of Python gui frameworks, but I am in a similar situation as the OP, i.e., a beginner looking to TRY some easy gui programming in Python. Not being a computer science person, just an amateur scripter, I tend to learn best from lots of examples.
With all of that as background, I downloaded the latest wxPython demos and docs yesterday. I suggest that the OP do the same. The demo.py program is an amazing piece of work. It's loaded with specific examples which allow you to view the frame or dialog etc, and then look behind it to see the code used to create it. rd -- http://mail.python.org/mailman/listinfo/python-list