Ant, Have you checked out the Dabo framework? Dabo provides a set of tools and underlying framework that makes VB style GUI development possible using Python.
Dabo is designed to be GUI framework independent however it currently only supports wxPython. Dabo has a very friendly and helpful mailing list if you want to give it a try. Dabo can be found here: http://dabodev.org Malcolm -- http://mail.python.org/mailman/listinfo/python-list
