Hi Yihui,
yes, RStudio works flawlessly with synchronization, but working with it I will 
lose all the features of a full-fledged tex editor, first of all BibDesk 
integration.
Texworks can also do two-way sync in Rnw, and I tried to switch configurations 
but with no luck.
In texworks I am using RScript with the options recommended in this document:

http://www.math.montana.edu/~jimrc/classes/Rseminar/TexWorks.pdf

The problem with texworks is the same: no integration with bibdesk
 


On Jan 9, 2013, at 4:06 PM, Yihui Xie wrote:

> I believe RStudio has done a fairly good job in terms of the
> synchronization. If you have to stick to TeXShop, I do not have any
> ideas on how to make it work with Sweave child documents.
> 
> Regards,
> Yihui
> --
> Yihui Xie <xieyi...@gmail.com>
> Phone: 515-294-2465 Web: http://yihui.name
> Department of Statistics, Iowa State University
> 2215 Snedecor Hall, Ames, IA
> 
> 
> On Wed, Jan 9, 2013 at 2:25 PM, michele caseposta <mic.c...@gmail.com> wrote:
>> Hello everyone.
>> I am in the process of writing a book in Latex with Texshop, on Mac.
>> This book contains a lot of R code, hence the need to use Sweave.
>> I was able to compile Rnw files, and to sync back and forth from the pdf to 
>> the source Rnw.
>> My problem now is that the book is divided in Chapters, and every chapter is 
>> in its own Rnw file.
>> I can compile them from the main one (book.Rnw) using the directive
>> 
>> \SweaveInput{chapter1.Rnw}
>> 
>> The problem stands in the fact that like this I am missing synchronization 
>> between the pdf and the source Rnw. If part of text is in book.Rnw I can 
>> synchronize, but if the text is in one of the included files, it just 
>> doesn't work.
>> I am using the sweave engine found in the following webpage:
>> 
>> http://cameron.bracken.bz/synctex-with-sweavepgfsweave-in-texshoptexworks
>> 
>> Has anybody succeeded in synchronizing with included Rnw files?
>> 
>> Thanks,
>> Mic

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