Concerning the debate about SAS vs. S/R I think that a multiple approach has to be taken. As far as I observed it many Pharmas are going to use more than one Spftwarepackage. We all now that S SAS SPSS and so on have their advantages and disatvantages. I think a modern statistician has to know at least three or four softwarepackages so that he can decide which problem can be solved by which software.
>On Thu, 27 Nov 2003 07:48:02 +0100 >"Antonia Drugica" <[EMAIL PROTECTED]> wrote: > >> I'm quite new to this medical stuff. But my associates told me that we >> are not free in choice of Statistical Software because the FDA has high >> standards concerning this topic. But if they would prefer a specific >> package (like SAS) that could mean, that this package vendourer could >> lay back and hold it's hand open for licence money. > >Your associates are completely wrong. It is only sponsors that choose not >to be free in their choice, due in my humble opinion mainly to the fact >that SAS has been in use since 1966 and that "no one has ever been >criticized by the FDA for using SAS." FDA even receives submissions based >on Excel and we all know about the accuracy of Excel's statistical >calculations. High standards need to be held by statisticians doing the >analyses. Related to such standards open source systems such as R have >many advantages, and the reproducible reporting capabilities of R using >its Sweave package have major impacts on accuracy of reporting. > >I along with colleagues at another institution are working on an open >source R package for clinical trial analysis and reporting that should be >mature in about a year. I am currently using the package in two >pharmaceutical industry-sponsored randomized clinical trials to report to >data monitoring committees. I'm also working on a document addressing >validation of statistical calculations. Let me know if you'd like a copy >of the current version of that document. > >> >> Is there any part of the ICH document referring to software packages? I >> really would use R for some tasks but therefor I need arguments... > >Don't know of anything in ICH. > >In view of the fact that large pharma companies have to pay more than $10M >per year in SAS licenses and have to hire armies of non-intellectually >challenged SAS programmers to do the work of significantly fewer >programmers that use modern statistical computing tools like R and S-Plus, >it is surprising that SAS is still the most commonly used tool in the >clinical side of drug development. I quit using SAS in 1991 because my >productivity jumped at least 20% within one month of using S-Plus. >--- >Frank E Harrell Jr Professor and Chair School of Medicine > Department of Biostatistics Vanderbilt University > -- Trebate bolji pristup internetu? Nazovite IskonInternet na 0800 1000 ili pogledajte http://www.iskon.biz/individualni/usluge/dialup/ ______________________________________________ [EMAIL PROTECTED] mailing list https://www.stat.math.ethz.ch/mailman/listinfo/r-help
