Thanks Cyril for your time and advises.
Vahid 

    On Friday, November 4, 2016 2:31 AM, Cyril Mory 
<[email protected]> wrote:
 

  Hi Vahid, It's becoming unclear to me, but I don't think you want to perform 
a dot product between a matrix and a vector. My advice: do the math, turn the 
equations into a pipeline (that's the tricky part) and try to copy some pieces 
of existing pipelines in RTK filters. And I don't recommend the 
rtkConjugateGradientFilter for this.
  Then run your pipeline with known data, and at every step where you have a 
known reference (e.g. from python code), compare the intermediate image you get 
with that reference. 
  As for the python wrapping: I personally have no experience with writing 
python wrappings for RTK. It is supposed to be easily done, but only for full 
RTK filters. You cannot wrap part of a filter. So you will have to create your 
own filter, and only then wrap it in python. If I'm mistaken, please, RTK 
users, do correct me :) Regards, Cyril
  On 11/03/2016 09:10 PM, vahid ettehadi wrote:
  
  OK. good. Thank Cyril to clarify it to me.  To implement the Newton's methods 
instead of multiplication of R with R^T, we need the multiplication of 
Jacobian/Sensitivity (R here) matrix with vector variable (here x) and the 
gradient vector (here multiplication of R with -r). I think it is possible to 
implement the Newton optimization methods with the current modules as I think 
we could extract the R and f dot product and R and r dot product. Am I right? 
About the displayed algorithms, I think the gradient vector is dot product of 
matrix A (Jacobian) with the minus residual vector (-r).   
  One more question: I already developed my codes in python. Do you think it is 
easy to wrap your modules in python? I don't have experience in these subject. 
  Regards, Vahid 
 
      On Thursday, November 3, 2016 2:23 AM, Cyril Mory 
<[email protected]> wrote:
  
 
    Hello Vahid, Thank you for this insight on Newton's methods. Yes, the 
output of the backprojection filter, in SART, is the gradient of the cost 
function. You may have noticed that the pipeline performs a division of the 
forward projection by something coming from "RayBoxIntersectionFilter". This is 
to normalize the forward projection, so that R^T R f ~= blurry f. If you don't 
do it, you'll have R^T R f ~= alpha * blurry f, with alpha that can reach 200 
or so, and your algorithm will quickly diverge.
   You could try to extract the gradient from the conjugate gradient filter as 
well, but it is significantly more tricky: first, the CG filter was implemented 
from the following algorithm, taken from wikipedia (which embeds the 
normalization I was mentioning earlier):  In this algorithm, it is not clear to 
me what exactly is the gradient of the cost function. I would say it is 
something like "- r_k", but I'm not sure. Second, as you see, the CG filter 
needs an operator A, which may differ from one problem to another, so this 
operator is implemented in a separate filter, which in your case would be 
rtkReconstructionConjugateGradientOperator, with  the laplacian regularization 
parameter gamma set to 0. 
  Note that we never actually store the system matrix R. Instead, the 
interpolation coefficient it contains are re-computed on the fly everytime we 
forward project. And the same holds for backprojection, i.e the matrix R^T. 
Best, Cyril
  
  On 11/03/2016 03:38 AM, vahid ettehadi wrote:
  
  Hello Simon and Cyril, Thanks for the reply. You are right Simon. I did not 
notice it too in the literature. The main problem as you said  is the storage. 
Actually I developed  the conjugate gradient (CG), quasi-Newton and Newton 
optimization methods for optical tomography and I intended to apply them to the 
CT reconstruction as well. I implemented the Newton's methods  (Gauss-Newton 
and Levenberg-Marquardt) in a Jacobian-Free-Newton-Krylov approaches to avoid 
the matrix multiplication of Jacobians (sensitivity). It means we only need to 
store the Jacobian matrix for the  these methods (the matrix R that Cyril was 
mentioned), that is still a big matrix for practical problems in CT 
reconstruction. For the quasi-Newton I adapted an L-BFGS algorithm that only 
need the 3 or 8 last  iterations of the gradient vector to calculate the 
Hessian matrix. In my case, the L-BFGS and Newton's methods was much faster 
than the CG as you know because of using the second order derivative (hessian 
matrix). I saw in your last paper  you implement the conjugate gradient method, 
so I thought it might be easy to extract the gradient vector from CG modules 
and solve the cost function within the quasi-Newton/Newton methods. I will look 
at the codes to see what I can do. Thanks again for the reply. 
  @Cyril: Please correct me if I am wrong. you mean the output of 
backProjectionFilter is the gradient of defined cost function? 
  Regards, Vahid 
 
      On Wednesday, November 2, 2016 2:53 AM, Cyril Mory 
<[email protected]> wrote:
  
 
    Hi Vahid, Welcome to RTK :) Indeed, there are several iterative methods 
already implemented in RTK, but none of the filters allows you to easily 
extract the gradient of the least  squares function there are minimizing. 
 If you need to minimize the classical non-regularized tomographic cost 
function, ie || R f - p ||², with R the forward projection operator, f the 
volume  you are looking for, and p the measured projections, my best advice 
would be to copy some part of the pipeline of 
rtkSARTConeBeamReconstructionFilter  to get the job done, ie the following part 
(copy-paste this into webgraphviz.com)
 
 digraph SARTConeBeamReconstructionFilter {
 
 Input0 [ label="Input 0 (Volume)"];
 Input0 [shape=Mdiamond];
 Input1 [label="Input 1 (Projections)"];
 Input1 [shape=Mdiamond];
 
 node [shape=box];
 ForwardProject [ label="rtk::ForwardProjectionImageFilter" URL="\ref 
rtk::ForwardProjectionImageFilter"];
 Extract [ label="itk::ExtractImageFilter" URL="\ref  itk::ExtractImageFilter"];
 MultiplyByZero [ label="itk::MultiplyImageFilter (by zero)" URL="\ref 
itk::MultiplyImageFilter"];
 AfterExtract [label="", fixedsize="false", width=0, height=0, shape=none];
 Subtract [ label="itk::SubtractImageFilter" URL="\ref  
itk::SubtractImageFilter"];
 MultiplyByLambda [ label="itk::MultiplyImageFilter (by lambda)" URL="\ref 
itk::MultiplyImageFilter"];
 Divide [ label="itk::DivideOrZeroOutImageFilter" URL="\ref  
itk::DivideOrZeroOutImageFilter"];
 GatingWeight [ label="itk::MultiplyImageFilter (by gating weight)" URL="\ref 
itk::MultiplyImageFilter", style=dashed];
 Displaced [ label="rtk::DisplacedDetectorImageFilter" URL="\ref  
rtk::DisplacedDetectorImageFilter"];
 ConstantProjectionStack [ label="rtk::ConstantImageSource" URL="\ref 
rtk::ConstantImageSource"];
 ExtractConstantProjection [ label="itk::ExtractImageFilter" URL="\ref 
itk::ExtractImageFilter"];
 RayBox [ label="rtk::RayBoxIntersectionImageFilter" URL="\ref  
rtk::RayBoxIntersectionImageFilter"];
 ConstantVolume [ label="rtk::ConstantImageSource" URL="\ref  
rtk::ConstantImageSource"];
 BackProjection [ label="rtk::BackProjectionImageFilter" URL="\ref 
rtk::BackProjectionImageFilter"];
 OutofInput0 [label="", fixedsize="false", width=0, height=0, shape=none];
 OutofBP [label="", fixedsize="false", width=0, height=0, shape=none];
 BeforeBP [label="", fixedsize="false", width=0, height=0, shape=none];
 BeforeAdd [label="", fixedsize="false", width=0, height=0, shape=none];
 Input0 -> OutofInput0 [arrowhead=none];
 OutofInput0 -> ForwardProject;
 ConstantVolume -> BeforeBP [arrowhead=none];
 BeforeBP -> BackProjection;
 Extract -> AfterExtract[arrowhead=none];
 AfterExtract -> MultiplyByZero;
 AfterExtract -> Subtract;
 MultiplyByZero -> ForwardProject;
 Input1 -> Extract;
 ForwardProject -> Subtract;
 Subtract -> MultiplyByLambda;
 MultiplyByLambda -> Divide;
 Divide -> GatingWeight;
 GatingWeight -> Displaced;
 ConstantProjectionStack -> ExtractConstantProjection;
 ExtractConstantProjection -> RayBox;
 RayBox -> Divide;
 Displaced -> BackProjection;
 BackProjection -> OutofBP [arrowhead=none];
 }
 
 As you can see, it is a very large part of the SART reconstruction  filter, so 
yoiu might be better off just copying the whole 
SARTConeBeamReconstructionFilter  and modifying it. 
 
 Of course, you could also look into ITK's cost function class, and see if one 
of the classes inherited from it suits your needs, implement your cost  
function this way, and use ITK's off-the-shelf solvers to minimize it. See the 
inheritance diagram in 
https://itk.org/Doxygen/html/classitk_1_1CostFunctionTemplate.html if you want 
to try this approach.
 
 Best regards,
 Cyril
 
  On 11/01/2016 05:50 PM, vahid ettehadi via Rtk-users wrote:
  
  Hello RTK users and developers, 
  I already implemented the RTK and reconstructed some  images with the FDK 
algorithm implemented in RTK. It works well. Thanks  to RTK developers.
  Now, I am trying to develop a model-based image  reconstruction for our 
cone-beam micro-CT. I see already that some  iterative algorithms like ART and 
its modifications and conjugate-gradient (CG) method are implemented in the 
RTK. I  want to develop a model-based reconstruction through the  
Newton/quasi-Newton optimizations methods. I was wondering is it possible to 
extract the gradient of least square  function from implemented algorithms like 
CG module? Any recommendation will be appreciated.  
  Best Regards, Vahid 
   
  
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