[ccp4bb] Multiple postdoc positions at Icahn School of Medicine, Mount Sinai, New York, USA

[Cheng Zhang]

Happy New Year!

Post for a friend. Please contact Dr. Yi Shi at wally@gmail.com or
yi@mssm.edu if you are interested. Please help to pass the information
to your colleagues, students, or trainees.

Multiple postdoctoral positions are immediately available in Shi laboratory
of Proteomics, Center for Protein Engineering and Therapeutics at Icahn
School of Medicine at Mount Sinai in NYC.

The lab is interested in developing biotechnologies for the analysis of
biomolecules and macromolecular assemblies, with a focus on mass
spectrometry/proteomic techniques. Recently, inspired by the high
translational potential of the camelid single-chain antibodies (so-called
nanobodies), our lab has developed robust pipeline technologies and tools
to facilitate nanobody drug discovery and therapeutic applications. The lab
is also interested in the development and application of integrative
structural approaches to study protein-protein and antibody-protein
interactions. An emerging direction of the lab is to conjugate machine
learning, structural biology, and proteomic approaches to facilitate the
bioengineering and design of novel protein therapeutics and vaccines. The
lab is vibrant, fun, and collaborative, and supports creative ideas and
career development.

References:

Kim, S.J., et al (2018). Integrative structure and functional anatomy of a
nuclear pore complex. *Nature*.

Xiang, Y., et al (2020). Versatile and multivalent nanobodies efficiently
neutralize SARS-CoV-2. *Science*.

Nambulli., et al (2021). Inhalable Nanobody (PiN-21) prevents and treats
SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. *Science
Advances*.

Xiang, Y., et al (2021). Integrative proteomics identifies thousands of
distinct, multi-epitope, and high-affinity nanobodies. *Cell Systems*.

Sun, et al. (2021). Potent neutralizing nanobodies resist convergent
circulating variants of SARS-CoV-2 by targeting novel and conserved
epitopes. *Nature Communications*.

Shen et al. (2021). A resource of high-quality nanobodies for drug
delivery. *iScience*.

Sang, et al. (2021) *Llamanade*: an open-source computational pipeline for
robust nanobody humanization. *Structure*.

Xiang et al (2022). Super-immunity by broadly protective nanobodies to
sarbecoviruses. *BioRxiv*.

Competitive salaries will be provided for successful candidates. Postdoc
housing is subsidized by the school of medicine. Motivated individuals
(Ph.D. or MD) with backgrounds in *mass spectrometry-based proteomics,
microbiology, structural biology (such as cryo-EM), and cancer
immunology* (ideally
with animal model experience) are particularly welcome to apply. Interested
candidates may submit their CVs, including names and contact information
for two-three references, a short description of their research experience,
and goals to Professor Yi Shi at (wally@gmail.com or yi@mssm.edu).

Visit our lab at: https://www.shi-lab.org/.

Some related news:

·Llama ‘nanobodies’ may yield COVID-19 treatment, Pitt scientists
say (The Philadelphia Inquirer)


·Why the lovable llama might be a secret weapon against
COVID-19 (Argonne National Library)


·COVID-19 breakthrough in llama nanobodies


·   Inhaled Nanobodies Protect Hamsters from COVID-19


·   Cheap, Potent Pathway to Pandemic Therapeutics


·Pitt Researchers Discover Llama ‘Nanobodies’ Are Powerful New
Coronavirus Treatment


·Pitt team discovers new way to find nanbodies to fight disease

[ccp4bb] Summer internships at Biogen

[Claire Metrick]

Hi all,

We are looking for three interns to join the Physical Biochemistry group at 
Biogen this summer including one focusing on crystallography and/or cryo-EM. 
Please see below and share with any star students who might want some hands-on 
time with our crystallography suite or vitrobot and Glacios this summer.

Thanks!
Claire


https://jobs.smartrecruiters.com/Biogen/743999797458287-intern-physical-biochemistry
This application is for a full-time internship role from June - August 2022. 
Resume review begins in January 2022.
We are looking for highly motivated students to join our Physical Biochemistry 
group within the department of Biotherapeutic and Medicinal Sciences at Biogen 
for a summer internship. The successful candidate will be part of a fast-paced 
and innovative environment actively pursuing unmet medical needs in the 
neuroscience space.
When you submit your resume, you may be considered for one of the following 
intern positions:

  *   Protein Purification: The candidate will express and purify recombinant 
target proteins and biophysically characterize them.
  *   NMR screening: The candidate will work with other NMR scientists in hit 
finding and characterize small molecule complexes with nucleic acids and 
proteins using NMR.
  *   Structural biology: Depending on interest and experience, the candidate 
will work on all steps of the structural biology pipeline, from protein 
expression and purification to structural characterization via crystallography 
and/or cryo-EM (both on site) and map and model building, refinement, and 
analysis.


Claire Marie Metrick, Ph.D.
Scientist II, Physical Biochemistry
Biogen | 225 Binney Street | Cambridge, MA | 02142
Email: claire.metr...@biogen.com | Direct: 
617.679.6444
www.biogen.com

[cid:image001.png@01D80644.E2358250]




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[ccp4bb] Fwd: Postdoctoral Research Associate in Chemical Biology at YSBL

[Mahima Sharma]

Dear colleagues

We have the following position available in the Davies Group at York
Structural Biology Laboratory, UK:
https://jobs.york.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=3885&p_web_page_id=468064



Applications are invited for either a Research Fellow or a Postdoctoral
Researcher to work on the activity-based proteomics and structural
enzymology of plant polysaccharide-degrading enzyme systems. The work is
funded by an ERC-Synergy grant to York, Barcelona and Leiden and is
available for up to 36 months. You will be supervised by Professor Gideon
Davies  and
will work in the ERC-Synergy team in the York Structural Biology
Laboratory, within Chemistry.

You will conduct research into activity-based probes, and other chemical
biology methods, applied to polysaccharide degrading/modifying enzymes. The
goal is to apply activity-based proteomics methods, in collaboration with
Leiden and Barcelona, to identify key enzyme systems involved in
polysaccharide degradation both fundamentally and for potential
biotechnological exploitation.

Note this post is available at grade 6 or grade with the grade 7 position
demanding a higher degree of experience and leadership. Please only apply
for the position commensurate with your experience and make clear on your
application which grade you are applying for.

*Apply by: 21/01/2022*

*Interview date: TBC*

*For informal enquiries:* please contact Prof Gideon Davies on
gideon.dav...@york.ac.uk

The Department of Chemistry  is one of
the largest and most successful departments at York and we are renowned
internationally for our research. As a department, we strive to provide a
working environment that allows all staff and students to contribute fully,
to flourish, and to excel. We are proud of our Athena SWAN Gold Award
.



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[ccp4bb] CALL FOR APPLICATIONS - GROUP LEADER POSITION IGBMC

[CAVARELLI Jean (VIE)]

Dear All 



We want to draw your attention to a tenure-track team leader position in 
cryogenic Electron Tomography (cryo-ET) which is about to open at IGBMC, and we 
would be grateful if you could disseminate this information to any motivated 
candidate. 




The main focus of this position is to strengthen and develop new research 
directions using cryo-ET, especially -but not exclusively, in situ cellular 
cryo-ET, and dedicated image analysis software. The junior professor will 
develop his own scientific project and consolidate the cryo-ET activities 
initialized by our teams. The position is supported by the Inserm and we are 
therefore particularly interested in attracting scientists with innovative 
research projects related to human health and diseases, and with experience and 
motivation for method optimization and development. 




This tenue-track junior professor position is a new type of academic position 
for France. To attract motivated candidates, the position offers a more 
competitive salary and, after successful evaluation, is converted into a senior 
Directeur de Recherche (DR) position, which is equivalent to a full 
professorship with little teaching duties. This is a more straightforward and 
fast way to obtain a senior position as compared to the regular academic 
carrier that requires a highly selective competition for upgrading to DR. The 
tenure-track period has been initially set to 5 years, but can be shorten upon 
demonstrated scientific performance. 




The junior professor will be immersed in the collaborative, interdisciplinary 
environment of IGBMC, a leading biomedical research centre bringing together 
research groups with interests in cell, molecular and structural biology ( [ 
https://www.igbmc.fr/en/ | link here ] ). The candidate will be supported by 
the cryo-EM platform of the Department of Integrated Structural Biology that 
hosts the French and European Infrastructures for Integrated Structural 
Biology, FRISBI and Instruct-ERIC, respectively [ 
https://www.igbmc.fr/en/plateforms-and-services/platforms/integrated-structural-biology
 | link here ] . It is equipped with cutting-edge instrumentation such as Titan 
Krios and Glacios cryo electron microscopes, and a cryo Focused Ion Beam 
Scanning Electron Microscope (FIB/SEM). The Titan Krios microscope is equipped 
with a Cs corrector, GIF energy filter, K3 camera and phase plates. A CLEM 
module (Leica Microsystems) is available for correlative cryo-fluorescent 
imaging and integrated sample transfer to cryo-FIB/SEM or cryo-TEM. In 
addition, the cryo-EM platform has a suite of associated equipment for sample 
preparation and dedicated computing resources for image processing and 3D 
reconstruction. New investments, in particular a second Titan-like instruments, 
are granted. 




The new group is expected to start in 2023 and will benefit from a start-up 
package. Application instructions can be found at the Inserm eva portal ( [ 
https://eva3-accueil.inserm.fr/sites/eva/appels-a-projets/Pages/default.aspx | 
link here ] ). Interested candidates can contact Prof. M. Eltsov 
(mikhail.elt...@igbmc.fr) or Dr P. Schultz (patrick.schu...@igbmc.fr) for 
further information. We will be happy to answer any questions and assist the 
candidates in framing the project in line with the requirements of call. 







Usefull links : 


IGBMC Web site 


[ https://www.igbmc.fr/en/ | https://www.igbmc.fr/en/ ] 


Intergated Structural Biology Platform 


[ 
https://www.igbmc.fr/en/plateforms-and-services/platforms/integrated-structural-biology
 | 
https://www.igbmc.fr/en/plateforms-and-services/platforms/integrated-structural-biology
 ] 


INSERM Portal 


https://eva3-accueil.inserm.fr/sites/eva/appels-a-projets/Pages/default.aspx 


https://eva3-accueil.inserm.fr/sites/eva/appels-a-projets/cpj/Pages/projets.aspx
 






- 
Jean Cavarelli 
Professor of Structural Biology 
"Structural biology of epigenetic targets" 
Department of Integrated structural biology 
IGBMC,UMR7104 CNRS-UNISTRA, INSERM U 1258 
phone : +33 (0)3 69 48 52 74 




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[ccp4bb] XDS package: new version and support for Apple M1

[Kay Diederichs]

Dear academic users of XDS,

there is an updated version available at https://xds.mr.mpg.de/ . Since the old 
(current) version will expire in March, it is advisable to download and test 
the updated version before that.
The biggest change is the availability of binaries for the Apple M1 processor. 
As you might know, the OSX_64 binaries (for Intel/AMD processors) do work on 
the Apple M1, but by emulation, and tests show that this native version is much 
faster. Feedback is welcome!

Best wishes for 2022!
Kay



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[ccp4bb] Research Scientist - protein purification (maternity cover)

[Leysen Seppe]

Hi everyone

Looking for your first job in the pharmaceutical industry? Do you enjoy protein 
purification, and can you operate an AKTA to run IMAC, IEX and SEC protein 
purifications without supervision? Do you want an opportunity to learn about 
antibody and small molecule drug discovery, by attending the project meetings? 
Then check out the maternity cover position (1 year contract) in our Protein 
Purification team at UCB (Slough, UK).
A full job description can be found below. If you want to apply, send your CV 
and cover letter to: 
protein.purificat...@ucb.com
Please note that you need to have the right to work in the UK.

Research Scientist - maternity cover - UCB (Slough, UK)
Everything we do starts with a simple question: "How will this make a 
difference to the lives of people living with severe diseases?" And to find the 
answers, we connect globally with patients and their families living with the 
physical and social burdens of severe disease. These connections give us new 
perspectives, drive our innovation, and offer a hope for a new generation of 
therapies that will help to transform lives.
Role overview
The Protein Production Group provides support for all NBE & NCE projects from 
early stage target validation through to those undergoing pre-clinical 
evaluation, by generating recombinant protein reagents for immunization, 
structural studies, assays and compound screening.  All reagents produced 
undergo biophysical analysis in order to enhance our understanding of their 
stability and solubility.  You will be part of the Protein Production Group 
playing a key role in project success by generating high quality protein 
reagents in a timely manner.
The successful candidate will have the opportunity to rapidly impact on a wide 
range of our NBE & NCE projects, and to significantly contribute to the 
progression of these projects into the clinic and beyond.
Primary responsibilities
*   You will be responsible for expressing and purifying high-quality 
recombinant protein reagents to support UCB's novel world-leading antibody and 
NCE drug discovery platforms for a variety of exciting therapeutic projects.
*   You will use your excellent practical skills, communication and team 
working abilities to drive innovative projects forward from the laboratory.
*   You will be responsible for clearly presenting work and engaging in 
discussion in a variety of cross-functional and external collaborator meetings.

Essential experience
Candidates may be fresh PhD holders with relevant experience, or Bachelor/MSc 
degree holders currently working as skilled Research Scientists, within the 
Biopharmaceutical or Pharmaceutical industry.
We are looking for candidates who are fully independent and competent in the 
following skill sets:
*   Molecular Biology (DNA manipulation techniques and use of VNTI and/or 
other DNA analysis software).
*   Protein Expression in E. coli and/or Mammalian cell systems.
*   Protein Purification (Affinity, Ion Exchange, Size Exclusion 
Chromatography, UV-Vis spectroscopy, protein refolding techniques and extensive 
working knowledge of AKTA purification platforms and associated software)
*   Protein Analysis (SDS PAGE, UPLC/HPLC, Western blotting)
*   Molecular Visualisation of proteins (PyMOL or similar).
*   Experience with X-ray crystallography or cryo-EM would be an advantage
*   Ability to work on several projects and conduct experiments in parallel.
*   Proficiency in the use of Microsoft Office.
*   A highly motivated individual with a proven ability to deliver to tight 
timelines.
*   A team player, with good organisational, communication, record keeping 
and inter-personal skills are essential requirements.
*   Presentations within the group and to project teams will also be 
expected.
*   Possess an inquisitive and innovative nature and a passion for 
delivering innovative new medicines for patients suffering with serious disease.

We can offer you the opportunity to rapidly impact on a wide range of our NBE & 
NCE projects, and to significantly contribute to the progression of these 
projects into the clinic and beyond.  Informal and open working environment 
that does not lock scientists into structure and hierarchy.  Freedom to take 
space to pursue your own ideas and make a difference.  Opportunities and 
expectations to develop global visibility and an international reputation as a 
scientist in your field.

Best wishes

Seppe Leysen
Principal Scientist
Protein Structure & Biophysics
UCB
216 Bath Road
SL1 3WE
Slough
UK



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[ccp4bb] Fw: Beamline Scientist opening at Diamond Light Source

[Hall, Dave (DLSLtd,RAL,LSCI)]

Hi

To give a little more time to polish applications after the holiday period 
we've extended the deadline for this role to Sunday 16th January.

Please get in touch if you would like further information about the role or 
whether your research would align with our aims alongside beamline operational 
support.

Best wishes

Dave


From: Hall, Dave (DLSLtd,RAL,LSCI) 
Sent: 17 December 2021 14:18
To: ccp4bb@jiscmail.ac.uk 
Subject: Beamline Scientist opening at Diamond Light Source


Hi Everyone



We have an opening at Diamond for people interested in a beamline scientist 
role to join the team. More details can be found at:



https://vacancies.diamond.ac.uk/vacancy/macromolecular-crystallography-beamline-scientist-465689.html



The closing date for applications is Sunday 9th January.



Best wishes

Dave

--

MX Group Leader

Diamond Light Source

www.diamond.ac.uk/mx



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