Re: [ccp4bb] Postdoctoral positions(2) in cryo-EM
Dear all, Just a reminder of the Postoctoral positions currently open in our laboratory. The positions are for 15 months initially, but extendable to up to 7 years! Harry up applying shortlisting of candidates started already! Best wishes, Ale PS. Get in touch with me directly if you require further info > On 10 Feb 2020, at 19:55, Alessandro Vannini wrote: > > Dear all, > I would like to draw your attention to two postdoctoral positions available > immediately in my laboratory to work on cryo-EM determination of complexes > operating at the interface of SMC complexes and the transcription apparatus. > The projects are well suited for individual with good experience in modern > Cryo-EM pipelines. For some projects datasets have been already collected and > await further processing while others samples are “cryo” ready. The > postdoctoral fellows will be based at the ICR in South Kensington (Glacios, > F20 in house + consortium Krios + eBIC) but is expected that will also > benefit from the top notch EM facility currently being set up at the Human > Technopole, Milan Italy (Krios, Glacios, Talos, Aquilos, CLEM and room > temperature tomography 300 Kv scope). > If interested please apply here: > > https://icr.tal.net/vx/appcentre-ext/brand-0/candidate/so/pm/1/pl/1/opp/995-Postdoctoral-Training-Fellow-in-Cryo-EM/en-G > > For general enquiries please write me directly. > > Cheers, > > Alessandro > > To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] Postdoctoral positions(2) in cryo-EM
Dear all, I would like to draw your attention to two postdoctoral positions available immediately in my laboratory to work on cryo-EM determination of complexes operating at the interface of SMC complexes and the transcription apparatus. The projects are well suited for individual with good experience in modern Cryo-EM pipelines. For some projects datasets have been already collected and await further processing while others samples are “cryo” ready. The postdoctoral fellows will be based at the ICR in South Kensington (Glacios, F20 in house + consortium Krios + eBIC) but is expected that will also benefit from the top notch EM facility currently being set up at the Human Technopole, Milan Italy (Krios, Glacios, Talos, Aquilos, CLEM and room temperature tomography 300 Kv scope). If interested please apply here: https://icr.tal.net/vx/appcentre-ext/brand-0/candidate/so/pm/1/pl/1/opp/995-Postdoctoral-Training-Fellow-in-Cryo-EM/en-G For general enquiries please write me directly. Cheers, Alessandro Sent from my iPhone To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] PhD position at the ICR, London, UK
Dear CCP4bb readers, a PhD position (starting in October 2015) is available in my laboratory (www.icr.ac.uk/alessandrovannini) at The Institute of Cancer Research (ICR, Chelsea, London, UK), to undertake crystallographic, single particle electron microscopy analysis and biochemical analysis of large eukaryotic transcriptional complexes. We are particularly interested in studying macromolecular complexes that are involved in cancer development and several projects (which require different skills) are available. Applications for PhDs are invited from talented graduates or final year undergraduates who hold or expect to gain a first or upper second class honours degree or equivalent, or a Masters degree, in a relevant subject. Successful candidates will undertake a four-year research training programme under the guidance of a supervisory team of our world-class researchers. Projects and their primary supervisors are listed below. Students receive an annual stipend, currently £21,000 per annum, as well as having fees and project costs paid for the four-year duration. The ICR is a college of the University of London and awards degrees of the University. Our studentships are funded from a range of sources, including Cancer Research UK Centre – a strategic partnership between Cancer Research UK, the ICR and The Royal Marsden NHS Foundation Trust which aims to enhance translational research –the Hensley Nankivell studentship fund, the FC Hunter studentship fund, and ICR core funding. How to apply: Full details about these studentship projects, and the online application form, are available on our website, at: www.icr.ac.uk/phds. Applications should be made online. Please ensure that you read and follow the application instructions very carefully. Closing date: Friday 6th March 2015 Best regards, Alessandro ** Dr. Alessandro Vannini Team Leader, Division of Structural Biology The Institute of Cancer Research Chester Beatty Laboratories 237 Fulham Road London, SW3 6JB United Kingdom Tel: +44 - (0)20- 7153 - 5557 Fax: +44 - (0)20- 7153 - 5457 Email: alessandro.vann...@icr.ac.uk www.icr.ac.uk/alessandrovannini **
Re: [ccp4bb] PostDoc - Structural Biology - Cancer
Dear CCP4ers, apologies but the actual deadline for the advertised post is the 29th November 2013 (and not 2014). So only one week left to apply and not one year. Best, Alessandro A post-doctoral position is available immediately in the laboratory of Dr. Alessandro Vannini, within the Division of Structural Biology at The Institute of Cancer Research in Chelsea, London, UK. We are looking for highly motivated individuals with a strong interest in structural characterization of multi-subunit macromolecular complexes. We currently employ single particle electron microscopy analysis and X-ray crystallography, as well as biochemical and biophysical analysis, to elucidate the role of the RNA Polymerase III and associated factors in cancer development. The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology and a sound knowledge in production and purification of macromolecular complexes for structural biology analysis. Previous experience with purification of multi-subunit complexes and/or biochemistry of protein-nucleic acid complexes would be beneficial. Previous experience in protein crystallography and/or single particle electron microscopy would be desirable. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £28,425 to £34,944 p.a. inclusive (based on previous post-doctoral experience). CV and covering letter must be submitted online at http://www.icr.ac.uk/jobsearch Job Ref. No. 1378320 Closing Date: 29th November 2013 For informal inquiries you can contact me directly at alessandro.vann...@icr.ac.uk
[ccp4bb] PostDoc - Structural Biology - Cancer
Dear CCP4ers, a post-doctoral position is available immediately in the laboratory of Dr. Alessandro Vannini, within the Division of Structural Biology at The Institute of Cancer Research in Chelsea, London, UK. We are looking for highly motivated individuals with a strong interest in structural characterization of multi-subunit macromolecular complexes. We currently employ single particle electron microscopy analysis and X-ray crystallography, as well as biochemical and biophysical analysis, to elucidate the role of the RNA Polymerase III and associated factors in cancer development. The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology and a sound knowledge in production and purification of macromolecular complexes for structural biology analysis. Previous experience with purification of multi-subunit complexes and/or biochemistry of protein-nucleic acid complexes would be beneficial. Previous experience in protein crystallography and/or single particle electron microscopy would be desirable. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £28,425 to £34,944 p.a. inclusive (based on previous post-doctoral experience). CV and covering letter must be submitted online at http://www.icr.ac.uk/jobsearch Job Ref. No. 1378320 Closing Date: 29th November 2014 For informal inquiries you can contact me directly at alessandro.vann...@icr.ac.uk
[ccp4bb] Post-doctoral position Structural Biology
Dear CCP4ers, a post-doctoral position is immediately available in my lab at the Institute of Cancer Research, Chelsea, London to study multi-subunit enzymes, transcription factors and regulatory complexes involved in RNA Polymerase III transcription (www.icr.ac.uk/alessandrovannini). The position is offered initially for 3 years but can be further extended. Expression and purification protocols from endogenous and recombinant sources have been already established in the lab and hybrid techniques (X-ray crystallography and EM) will be employed for structural characterization. Please find below details on how to apply. For informal inquiries you can contact me directly at alessandro.vann...@icr.ac.uk . Best, Ale A post-doctoral position is available immediately in the laboratory of Dr. Alessandro Vannini, Division of Structural Biology at The Institute of Cancer Research. We are looking for highly motivated individuals with a strong interest in structural characterization of multi-subunit macromolecular complexes. We currently employ single particle electron microscopy analysis and X-ray crystallography, as well as biochemical and biophysical analysis, to elucidate the role of the RNA Polymerase III and associated factors in cancer development. The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology and a sound knowledge in production and purification of macromolecular complexes for structural biology analysis. Previous experience with purification of multi-subunit complexes and/or biochemistry of protein-nucleic acid complexes would be beneficial. Previous experience in protein crystallography and/or single particle electron microscopy would be desirable. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £28,425 to £34,944 p.a. inclusive (based on previous post-doctoral experience). CV and covering letter must be submitted online at http://www.icr.ac.uk/jobsearch Job Ref. No. 1378320 Closing Date: 29th November 2013
[ccp4bb] Postdoctoral position, structural biology of multi-subunit macromolecular complexes
Dear CCP4ers, a PostDoctoral position is immediately available in Alessandro Vannini's lab at the Institute of Cancer Research in central London to structurally and functionally characterise large multi-subunit complexes involved in eukaryotic transcription (www.icr.ac.uk/alessandrovannini). We are looking for highly motivated and creative individuals with a strong interest in structural characterization of multi-subunit complexes. We currently employ single particle electron microscopy analysis and x-ray crystallography, as well as biochemical and biochemical analysis, to elucidate the role of the RNA Polymerase III transcription apparatus in cancer and other fundamental cellular processes. The lab is well equipped with a fleet of AKTAs (including a brand new AKTA Pure) and have access to divisional managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of multi-subunit complex production and purification. Experience in purification of recombinant and/or endogenous proteins for structural biology analysis is essential for this post. Experience in protein crystallography and/or single particle electron microscopy would be desirable. Individuals with a strong background in biochemical characterization of transcription machineries wishing to learn structural biology techniques will be taken into serious consideration. The lab is located in the heart of central London, in the vibrant area of South Kensington. Appointment will be on Fixed Term Contract for 2 years in the first instance, with a starting salary in the range of £28,087 to £34,529 p.a. inclusive (based on previous post-doctoral experience). CV and cover letter must be submitted online at http://www.icr.ac.uk/jobsearch Informal enquiries can be sent directly to alessandro.vann...@.icr.ac.uk Job Ref. No. 1355633 Closing Date: 15/09/2013 Cheerio, Ale
[ccp4bb] Postdoctoral position at the ICR, central London
Dear CCP4ers, a PostDoctoral position is immediately available in Alessandro Vannini's lab at the Institute of Cancer Research in central London to structurally and functionally characterise large multi-subunit complexes involved in eukaryotic transcription (www.icr.ac.uk/alessandrovannini). We are looking for highly motivated and creative individuals with a strong interest in structural characterization of multi-subunit complexes. We currently employ single particle electron microscopy analysis and x-ray crystallography, as well as biochemical and biochemical analysis, to elucidate the role of the RNA Polymerase III transcription apparatus in cancer and other fundamental cellular processes (www.icr.ac.uk/alessandrovannini). The lab is well equipped with a fleet of AKTAs (including a brand new AKTA Pure) and have access to divisional managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of multi-subunit complex production and purification. Experience in purification of recombinant and/or endogenous proteins for structural biology analysis is essential for this post. Experience in protein crystallography and/or single particle electron microscopy would be desirable. Individuals with a strong background in biochemical characterization of transcription machineries wishing to learn structural biology techniques will be taken into serious consideration. The lab is located in the heart of central London, in the vibrant area of South Kensington. Appointment will be on Fixed Term Contract for 2 years in the first instance, with a starting salary in the range of £28,087 to £34,529 p.a. inclusive (based on previous post-doctoral experience). CV and cover letter must be submitted online at http://www.icr.ac.uk/jobsearch Informal enquiries can be sent directly to alessandro.vann...@.icr.ac.uk Job Ref. No. 1355633 Closing Date: 15/09/2013 Cheerio, Ale
[ccp4bb] Postdoctoral position at The Institute of Cancer Research, Chelsea - London
Following on a BBSRC New Investigator Award, a post-doctoral position is available immediately in the laboratory of Dr. Alessandro Vannini, Division of Structural Biology at The Institute of Cancer Research in London (www.icr.ac.uk/alessandrovannini). We are looking for highly motivated and creative individuals with a strong interest in structural characterization of large multi-subunit complexes. We currently employ single particle electron microscopy analysis and x-ray crystallography, as well as biochemical and biochemical analysis, to elucidate the role of the RNA Polymerase III transcription apparatus in cancer and other fundamental cellular processes. The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of multi-subunit complex production and purification. Experience in purification of multi-subunit protein complexes and yeast genetics is essential for this post. Experience in protein crystallography and/or single particle electron microscopy and protein production in insect cells (MultiBac) would be desirable, but individuals with a strong background in yeast genetics and/or biochemistry of multi-subunit complexes wishing to learn structural biology techniques will be taken into serious consideration. Appointment will be on Fixed Term Contract for 2 years in the first instance, with a starting salary in the range of £28,087 to £33,318 p.a. inclusive (based on previous post-doctoral experience). Informal enquiries to alessandro.vann...@icr.ac.uk and applications must be submitted in line with the instructions on our website: http://www.icr.ac.uk/jobs/index.shtml, quoting reference 1336320. Closing date June 20th 2013. Dr. Alessandro Vannini Team Leader, Division of Structural Biology The Institute of Cancer Research Chester Beatty Laboratories 237 Fulham Road London, SW3 6JB United Kingdom
[ccp4bb] Post-Doc position at ICR, London
We seek to appoint a post-doctoral training fellow to the Division of Structural Biology in the new team led by Dr Alessandro Vannini to undertake crystallographic, single particle electron microscopy analysis and biochemical analysis of large macromolecular complexes that assemble at RNA Polymerase III loci across the eukaryotic genome, in order to mechanistically understand their role in cancer and other fundamental cellular processes (www.icr.ac.uk/alessandrovannini). The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of protein crystallography an/or single particle electron microscopy. Experience in the biochemical and biophysical characterization of multi-subunit and protein-nuclei acids complexes is highly desirable. Experience in protein production in insect cells (MultiBac) or yeast genetics would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £27,536 to £33,852 p.a. inclusive (based on previous post-doctoral experience). For further particulars and details of how to apply, please check the current vacancies in the division of Structural Biology on our online application website (https://www.icr.ac.uk/jobs/index.shtml) and refer to this vacancy (n. 1228522). Closing date: 16th May 2012 Please direct informal inquiries to Dr. Alessandro Vannini at alessandro.vann...@icr.ac.uk
[ccp4bb] Job posts - ICR, London, UK
Dear CCP4bb readers, a postdoctoral position and a scientific officer / higher scientific officer position are available at The Institute of Cancer Research (ICR, Chelsea, London, UK), to undertakes crystallographic, single particle electron microscopy analysis and biochemical analysis of large eukaryotic transcriptional complexes. We are particularly interested in studying macromolecular complexes that are involved in cancer development and several projects (which require different skills) are available. The Division of Structural Biology of the ICR has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants for the postdoctoral position should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of protein purification for structural biology analysis. Experience in recombinant protein production and purification as well as protein crystallography and/or single particle electron microscopy is essential. Experience in the biochemistry of multi-subunit protein complexes, yeast genetics or protein production in insect cells (MultiBac) would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £27,536 to £33,852 p.a. inclusive (based on previous post-doctoral experience). For further particulars and details of how to apply, please refer to this vacancy on our online application portal: Ref n. 1228522 Applicants for the scientific officer / higher scientific officer should possess a BSc. (or equivalent) in molecular biology or cell biology with sound knowledge of cloning techniques. Experience in molecular cloning and protein expression is essential. Experience in yeast genetics and/or or protein production in insect cells (MultiBac) would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £23,000 to £29,545 p.a. inclusive dependant on skills and experience. In addition to annual performance related pay awards we offer a generous leave entitlement of 25 days annual leave per annum which rises to a maximum of 30 days per annum related to length of service, as well as 8 bank/public holidays and 3 additional ICR-set privilege days per annum. For further particulars and details of how to apply, please refer to this vacancy on our online application portal: Ref n. 1228533 Closing date: 8th February 2012 Please direct informal inquiries to Dr. Alessandro Vannini at alessandro.vann...@icr.ac.uk Please DO NOT send your application to Dr. Alessandro Vannini; CVs must be submitted in line with the instructions above.
Re: [ccp4bb] About SAD phasing
no it's called SAD exactly for that reason .. it's SAD that somebody developed a phasing method that does not solve the phase problem! sorry, stupid joke ... google (at least) is our friend btw ale P please don't print this e-mail unless you really need to *** Dr. Alessandro Vannini, PhD Cramer lab Gene Center, Deparment of Chemistry and Biochemistry Ludwig-Maximilian-Universität München Feodor-Lynen-Str. 25 81377 München Tel. : +49-89-2180-76955 On 30 Aug 2010, at 20:32, Jane Bailey wrote: Hi, All I would like to ask whether is it possible to allocate the Se site and obtain the phase by just using the SAD data set (no native dataset used)? Thanks, Qing
Re: [ccp4bb] Halide soaking
Hi, it worked very nice for me in 1 out of 1 case where I tried it :-). Very well diffracting crystals (1.8 Ang), rather small protein 20 kDa, 50 %solvent content, 1 mol/ASU. 20-30 s soak in 0.5 M NaBr resulted in 6 nice ordered sites. It was crucial for us to collect a 3 wavelength MAD data set. A SAD data set (using just the peak, even if with high redundancy ) was not enough to obtain traceable electron density map, even-though one could distinguish clearly protein boundaries and solvent channels. Good luck Ale On 31 Mar 2009, at 18:19, tat cheung cheng wrote: Hi all I am now trying to do bromide soaking, but i am not really sure does the bromide atom enter my crystal. So is there any signs that indicate the entry of bromide atom? e.g. does the space group, cell dimension change? or just nothing change, and the bromide atom just get in? Thanks very much. T.C. Cheng Yahoo!香港提供網上安全攻略，教你如何防範黑客! 請前往 http://hk.pro mo.yahoo.com/security/ 了解更多!
Re: [ccp4bb] structure (factor) amplitude
Dear Tassos, just to add some pepper to the conversation, I am obliged to say that Chichero (as it's typed) in modern (as well as in old) italian would be pronounced in exactly the same way as greek Kikero ... Does it help, or make more confusion ??? :-) alE PS. I am also for Structure factor amplitude. I learned it like that and, you know, change is bad *** Dr. Alessandro Vannini, PhD Cramer lab Gene Center, Deparment of Chemistry and Biochemistry Ludwig-Maximilian-Universität München Feodor-Lynen-Str. 25 81377 München Tel. : +49-89-2180-76955 On 12 Jan 2009, at 15:15, Anastassis Perrakis wrote: This chain reminds me of another discussion we had during dinner at Grenoble in the late '90s. The topic of the argument was how to pronounce the name 'Cicero'. Namely, my Italian friend (Gino C) was claiming it should be pronounced like in modern Italian, 'Chichero', while I was claiming that since the contemporary Greeks transcribed it as 'Kikero' (with a k) it should indeed sound as in modern Greek, Kikero. My learned Dutch colleague (Mark vR) after a few minutes of this rather dull argument he exclaimed in the well known Dutch diplomatic manner: 'But, who chares?' Not that I don't care, but I would personally understand the same thing in both cases - and I am enjoying the argument. A. PS Wikipedia says: Marcus Tullius Cicero (Classical Latin pronounced [ˈkikeroː], usually pronounced /ˈsɪsəɹəʊ/ in English; January 3, 106 BC – December 7, 43 BC) was a Roman statesman, lawyer, political theorist, philosopher, and Roman constitutionalist. On Jan 12, 2009, at 14:48, Ian Tickle wrote: Hi Gerard Marc My answer was my interpretation of Bernhard's original question what *is* the currently accepted name of the object whose description is 'structure factor amplitude' ?, and was based both on authoritative precedent, i.e. ITC Vol. B, and on frequency of current usage, i.e. Google hits. Carroll was making the point that in logic the name of an object is minimally only an arbitrary string of characters (preferably pronounceable!), like the name of a variable in a program, which minimally need have no semantic connotations whatsoever: a rose by any other name would smell as sweet. The only requirement is that it must not be ambiguous, i.e. you can't have two different objects within the same context with the same name. For example my name 'Ian' provides no semantic clues as to my description (except perhaps that I'm male), and causes no problems provided no other 'Ian's enter the discussion. However alternate names for the same object are clearly allowed (consider names of objects in different languages). In this case I am not offering an opinion on what I think the name *should be*, I am merely reporting on what the name *is* (however illogical), based on precedent and usage. However I do accept your argument that when making up the compound name of an object, it should as far as possible also be accurately descriptive in the way it relates to the names of related objects, consistent with the conflicting needs for abbreviation and lack of ambiguity. You are going much further than me: you are answering a different question what *should be* the accepted name of ... ?. In this case you have clearly made a strong argument, which I accept, for establishing an alternate name for this particular object. However one should not create new names or change the names of objects lightly, if misunderstandings are to be avoided. Fortunately in this case it can be done with minimal misunderstanding on the part of the readers of Bernhard's textbook (though others may disagree on that point), provided it is pointed out that there is precedent for an alternative name for the object in question, and perhaps a reference should be made to the original authoritative definition. Cheers -- Ian -Original Message- From: Gerard Bricogne [mailto:g...@globalphasing.com] Sent: 12 January 2009 12:09 To: Ian Tickle Cc: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] structure (factor) amplitude Dear Ian, My reply to this question will be less literate and less democratic than yours. In spite of the nice Alice quote, I remain in favour of trying to use compound names whose internal structure is, as much as possible, isomorphic to the composition of meanings they refer to (even though I am not necessarily an unconditional fanatic of OOP). Even if, allegedly, only God has a name for each object that completely specifies it and even gives it its very existence, I feel it is not unrealistic nor immodest to do our best to achieve this in our scientific language. If we modelled the rigour of scientific language on that of Lewis Carroll's, we would be in serious trouble (perhaps this is why scientists enjoy his humour so much: it is like taking
