[ccp4bb] Job Opportunity: Beamline Scientist at Canadian Light Source

2024-04-23 Thread Michel Fodje 
Hello everyone,

The Canadian Light Source, Inc. (CLSI) is seeking a qualified individual to 
join our MX team as a Scientist for the CMCF Beamlines. This role is pivotal in 
supporting and developing the beamlines' capabilities and collaborating with a 
diverse user community to enhance structural biology research.

Position Details:

  *   Job Title: Scientist, CMCF Beamlines
  *   Location: Canadian Light Source Inc., Saskatoon, SK
  *   Job Type: Full-time

The ideal candidate will have a strong background in X-ray crystallography or 
related fields, proven experience with beamline instrumentation, and excellent 
communication skills. For more information and to apply online, please visit 
the following link:

https://www.northstarats.com/Canadian-Light-Source

Please feel free to share this announcement with anyone who may be interested.

Regards

Michel Fodje
Senior Scientist, MX Group Leader | Canadian Light Source
44 Innovation Boulevard, Saskatoon, SK S7N 2V3
P: 306-657-3758

[cls_logo_signature]



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[ccp4bb] JOB OPPORTUNITY: Technician/Senior Technician in Biophysics in Milan

2024-04-09 Thread Sebastiano Pasqualato 

Dear all,
please advertise this job opportunity.

The Biophysics Unit of the National Facility for Structural Biology of Human 
Technopole, in Milano, Italy, is seeking to recruit a research technician who 
will actively participate in maintaining instruments and workflows, take part 
in scientific collaborations, and support internal and external users.
The Biophysics Unit manages equipment and provides service/support to 
researchers for biophysical characterisation of macromolecular samples, and the 
determination/characterisation of interaction affinities.

We are equipped with a state-of-the art equipment for ITC, BLI, MST, Mass 
Photometry, SEC-MALLS, nanoDSF measurements and are embedded in the Centre for 
Structural Biology of HumanTechnopole, lead by Alessandro Vannini and Gaia 
Pigino, and are part of the National Facility for Structural Biology, an 
integrative structural biology Facility comprising Cryo-EM, Biomass Production, 
Biophysics, Structural Proteomics and Single Molecule Dynamics Units.

All details about the job, and how to apply, here: 
https://careers.humantechnopole.it/o/technician-senior-technician-in-biophysics
Further information directly to me: sebastiano.pasqualato (at) fht.org 


Come join us for the ride, and live in Milan, a thriving city which will be 
home of the Winter Olympic Games 2026!

Thanks for sharing,
best,
Sebastiano





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[ccp4bb] Job opportunity at SARomics Biostructures in Lund, Sweden

2024-02-04 Thread Derek Logan 
Posted on behalf of SARomics Biostructures AB!
Best regards
Derek Logan

Open position: Research Scientist in structural biology
SARomics Biostructures is one of the fast-growing biotech companies in Lund, 
Sweden. We strive to accelerate drug discovery through structural insight. Our 
international team of over 25 researchers covers the following fields of 
expertise: protein engineering, expression, purification and characterization, 
biophysical screening, protein NMR analysis, protein X-ray crystallography, and 
computational chemistry. SARomics has built a global reputation for its 
structural biology platform and structure-based drug design skills and is 
currently supporting mainly international clients in pursuing their drug 
discovery objectives. In parallel, the company is pursuing several internal 
drug discovery projects to discover leads for new medicines.

We seek skilled and highly motivated research scientists to expand and 
strengthen our team, which works on protein production and crystallization. The 
candidate can either have strong protein expression and purification skills or 
have some competence in protein production and crystallization. While not 
necessary, having competencies in both areas will be considered an advantage. 
The position involves working closely with an experienced team of 
interdisciplinary researchers and regularly presenting findings to the project 
team, senior management, and clients.

The ideal candidate will be self-driven, resourceful, organized, focused, 
service-minded, and enjoy working in a dynamic, fast-paced team environment. 
The candidate should have a strong desire to learn new techniques, incorporate 
new methodologies into their work, and carry out innovative and high-quality 
research to answer challenging questions in structural biology.

Successful candidates' requirement
• Ph.D. in biochemistry, biotechnology, molecular biology, structural biology, 
or related fields
• Experience in independent planning and performing of experiments and 
analyzing and drawing conclusions from generated data in a scientific research 
setting
• An understanding of protein structure and biophysical properties
• Have excellent analytical, organizational, and communication skills - fluency 
in English (spoken and written) is expected
• Ability and desire to work in a fast-paced, dynamic environment to ensure 
timely progress in customers' projects
• Legally authorized to work in Sweden

Required knowledge, skills, and abilities

For protein production
• Expertise in recombinant protein expression in E. coli, insect, and mammalian 
cells
• Expertise in recombinant protein purification using affinity chromatography, 
IMAC, SEC, IEX, etc.
• Working knowledge and practical experience with ÄKTA systems will be highly 
advantageous
• Expertise with general protein characterization techniques such as SDS-PAGE 
gel, Western blot, thermal shift assays, etc.

For crystallization
• Experience of protein crystallization of a wide variety of proteins
• Experience in all steps of structure determination (including data collection 
to refinement)
• An ideal candidate will also have experience with structure-based design and 
drug discovery projects

The successful candidate will get the opportunity:
• to join an energetic and enthusiastic international team with a focus on 
scientific excellence and teamwork
• to evolve in a highly multidisciplinary environment and thus develop new 
competencies outside their core expertise
• to accelerate discovery through structural insight

Explore our website to find out what it is like to work at SARomics 
Biostructures: http://www.saromics.com/
Please call Nadia Rose (+46 46 26 10 474) for specific questions regarding the 
positions.

If you are interested in a career with us, please forward a CV/resume and a 
cover letter to i...@saromics.com and label your message with the subject "SBX 
Career" no later than February 18th, 2024.

We will interview candidates continuously and would therefore like to receive 
your application as soon as possible!
The application should be in English.












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[ccp4bb] Job Opportunity at the CeTPD

2023-01-05 Thread Valentina Spiteri 
Hi All, 

We are looking for a structural biologists/ biophysicist to join the Alessio 
Ciulli/Boehringer Ingelheim collaboration at the newly opened Centre for 
Targeted Protein Degradation at the University of Dundee. 

This is a fantastic opportunity to work with an amazing team of 
interdisciplinary scientists working on some really cool science. 

https://www.jobs.ac.uk/job/CWG217/research-scientist 


Best wishes,

Valentina 


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[ccp4bb] Job opportunity in Berlin - HZB and Humboldt University advertise a postdoc position

2022-04-20 Thread Manfred S. Weiss 


The Helmholtz Zentrum Berlin für Materialien und Energie, the 
Max-Delbrück-Center for Molecular Medicine, the Freie Universität Berlin, the 
Charite, the Max-Planck-Institute for Colloids and Interfaces  and the Humboldt 
Universität zu Berlin jointly operate three experimental stations for 
bio-macromolecular crystallography at BESSY II, Berlin's modern synchrotron 
radiation source, located in the lovely southeast of Berlin.

(https://www.helmholtz-berlin.de/forschung/oe/ps/macromolecular-crystallography/index_en.html)

The Humboldt University zu Berlin is seeking a

Post Doctoral Research Assistant

to work on and support research topics in the field of structural enzymology 
(e.g. control of chemical reactions in macromolecular crystals, combination of 
UV/Vis absorption spectroscopy and crystallography, etc.) originating from the 
group of Prof. Dr. Holger Dobbek. The successful candidate will also be 
involved in the operation of the BESSY II bio-macromolecular crystallography 
beamlines (headed by Dr. Manfred S. Weiss) including supporting external users 
at the beamlines and will take part in graduate student education.

Initially,  a contract lasting until 31.12.2023 will be offered to the 
successful candidate with the possibility for an extension. The salary will be 
based on German Federal TVöD. The position is available immediately.

Applicants should hold a Ph.D. in the biological, chemical or physical sciences 
and have a solid background in biochemical methods, in bio-macromolecular 
crystallography and/or related fields. The position also requires the 
documented ability to conduct independent research as well as excellent 
communication and interpersonal skills.

Please send applications (CV, list of publications, references, .pdf-file 
format) citing the reference number AN/073/22 in electronic form until 
28.04.2022 to:

Dr. Manfred Weiss 
(mswe...@helmholtz-berlin.de)

Here is the link to the job advertisement (in German):

https://www.personalabteilung.hu-berlin.de/de/stellenausschreibungen/wissenschaftliche-r-mitarbeiter-in-m-w-d-befristet-bis-31-12-2023-e-13-tv-l-hu






--
Dr. Manfred S. Weiss
Macromolecular Crystallography
Helmholtz-Zentrum Berlin
Albert-Einstein-Str. 15
D-12489 Berlin
Germany



Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.

Aufsichtsrat: Vorsitzender Dr. Volkmar Dietz, stv. Vorsitzende Dr. Jutta 
Koch-Unterseher
Geschäftsführung: Prof. Dr. Bernd Rech, Thomas Frederking

Sitz Berlin, AG Charlottenburg, 89 HRB 5583

Postadresse:
Hahn-Meitner-Platz 1
14109 Berlin
Deutschland



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[ccp4bb] Job opportunity in cryoEM and protein engineering, Boston US

2022-01-03 Thread Yanfeng Zhou 
Hi all,
Happy New Year!

Seismic Therapeutic is looking for a Senior Scientist/Scientist in cryoEM
structural biology and protein engineering.

https://seismictx.com/

or
https://www.linkedin.com/jobs/view/2850560615/?refId=GdmYlESlwExabGNyXfQKZA%3D%3D


*About Seismic*: Seismic is determined to help patients with unmet need by
integrating machine learning, structural biology, protein engineering, and
translational immunology to generate clinic-ready drugs. At our core, we
are focused on phenomenal science, supportive culture, a superstar team,
meritocracy, and patient-centric goals. Seismic has the tools, skills,
ideas and people to make this a reality. Success will be the discovery and
development of effective therapies for patients in need, and we invite you
to become a part of that.

*Responsibilities:*

·   Design and implement structural biology experiments, including
protein production and characterization, structure determination and
analysis.

·   Design and optimize biophysical and biochemical studies of
biotherapeutic molecules using a range of methods for candidate
optimization and development.

·   Closely collaborate with a diverse team of wet-lab scientists,
protein engineers, and machine learning computation scientists.

·   Manage and direct CROs

*Who You Are: *

·   A rigorous scientist with a deep understanding of protein
biochemistry and structure

·   Enthusiastic and innovative

   - Intellectually curious with a passion for exploring new approaches for
   better and faster structure determination and rational design
   - Bold in proposing creative experimental designs and ideas, relentless
   in pursuing successful outcomes

·   Driven and conscientious, thrives in a fast-paced, entrepreneurial
environment

·   Passionate about improving patients’ lives

*Qualifications:*

·PhD in structural biology, chemistry, biology, biochemistry,
biomedical engineering, or related field

·   Strong expertise in protein construct design, protein expression
and purification, sample vitrification, data collection with direct
electron detectors and structure determination.

·   Solid experience with structure analysis and characterization of
structure-function relationship.

·   Strong collaborative, organizational, and presentation skills

·   Ability to direct Research Associates, Technicians and CRO’s

· Ability to document, maintain, and share an organized account of lab
work and results



As a member of our diverse and growing team, you’ll help shape Seismic into
a company that takes its scientific mission seriously while providing a
positive and supportive workplace environment and culture. With your
insights, passion and talent - we’ll bring novel therapeutics to the
patients who need them the most.


Best,

Yanfeng



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[ccp4bb] Job Opportunity at Surrozen (SFO Bay Area): Research Associate/Senior Research Associate, Biochemistry and Biophysics

2021-12-14 Thread Parthasarathy Sampathkumar 
Dear All,

I would like to bring to the attention of suitable candidates the following
exciting job opportunities at Surrozen Inc, located in South San Francisco.

Surrozen is a biotechnology company focused on discovering and developing
novel regenerative medicines with a focus on unlocking the powerful
self-renewal properties of the body through specific control of the Wnt
signaling pathway.

Our vision is to engage the body’s own biological tissue repair mechanisms
with our targeted regenerative antibodies, overcoming research and
development hurdles that have been previously intractable, and have held
back drug development efforts in the promising area of Wnt biology.

*Research Associate/Senior Research Associate, Biochemistry and Biophysics:*

https://apply.workable.com/surrozen/j/ACBA0B0D96/

*Scientist, Protein Sciences: *
https://apply.workable.com/surrozen/j/DF4518083F/

*Research Associate, Protein Purification:*
https://apply.workable.com/surrozen/j/7D64A01556/

Many Thanks,
Best Wishes,
Partha Sampathkumar PhD
Principal Scientist
Surrozen Inc
Email: par...@surrozen.com



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[ccp4bb] Job opportunity: Research scientist in PROTAC drug discovery

2021-06-11 Thread David Zollman (Staff) 
Dear crystallographers/biophysicists,



We have a particularly exciting job opportunity in our lab, the PROTAC drug 
discovery collaboration between the group of Prof Alessio Ciulli at the 
University of Dundee and Boehringer Ingelheim. Our group are world leaders in 
the field of PROTACs, which has rapidly become one of the hottest topics in 
drug discovery. We are looking to recruit one new team member to help expand 
our structural biology, protein production and biophysical efforts.

If you have relevant doctoral/post-doctoral experience and are interested in 
joining a highly motivated, dynamic, interdisciplinary group at the interface 
of academia and industry, the deadline for application is Wednesday 23rd June. 
The post is available for an immediate start, with funding until 31st August 
2023 in the first instance. Salary will depend on experience, but the 
appointment will be at Grade 7 on the University's salary scale (between 
£32,817 - £40,322). The full job advert including details on how to apply can 
be found at:

https://www.lifesci.dundee.ac.uk/vacancies/2021/may/24/structural-biology-biophysics-scientist-protac-drug-discovery



Best wishes,

David Zollman

The University of Dundee is a registered Scottish Charity, No: SC015096



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Re: [ccp4bb] Job opportunity for structural biologists and biophysicists at Vertex Pharmaceuticals in Oxford - new link

2021-04-22 Thread Liz Carpenter 
Dear All,
Following on from my previous posting we have one more position to fill at 
Vertex for a structural biologist with experience in biophysics, structural 
biology and protein biochemistry to join our expanding team in Oxford.
Experience in working with challenging membrane proteins and protein complexes, 
using both cryo-EM and crystallography, would be advantageous for these roles.

If you have a passion for tackling difficult targets and being involved in 
developing therapies for patients with serious genetic diseases, please follow 
the link below to learn more about this position.

https://vrtx.wd5.myworkdayjobs.com/Vertex_Careers/job/Oxford-United-Kingdom/Structural-Biology-and-Biophysics-Research-Scientist_REQ-11435-2

With best wishes,
Liz Carpenter



This email message and any attachments are confidential and intended for use by 
the addressee(s) only. If you are not the intended recipient, please notify me 
immediately by replying to this message, and destroy all copies of this message 
and any attachments. Thank you.



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[ccp4bb] Job Opportunity at NIH

2020-11-25 Thread Esser, Lothar (NIH/NCI) [E] 
Hi,
on behalf of Dr. Di Xia, I am posting this interesting job opportunity:







We are looking for a young research scientist with a recent Ph.D. in structural 
biology with training in cryo-EM/X-ray crystallography to join our Section of 
Structural Biology of Membrane Proteins in the Laboratory of Cell Biology, 
Center for Cancer Research, National Cancer Institute, NIH to work on 
"Mechanistic investigation of cellular respiratory chain in drug resistance ".  
The project involves structural study of mitochondrial proteins that are 
targets of antimicrobial compounds.  It is anticipated that multiple structural 
techniques will be employed, involving the use of X-ray crystallography and 
Cryo-EM to illuminate structural aspects of target protein response to drug 
treatment.  Our group has assured access to a synchrotron beam line at APS and 
to an intramural EM facility equipped with a Krios microscope and Gatan K3 
detector.  While the candidate should have structural biology expertise, they 
are not expected to be proficient in all structural biology techniques. The 
successful candidate should have practical experiences in molecular biology and 
protein purification for target proteins production. Experience in 
mitochondrial proteins is a plus. NIH has a welcoming, collaborative and 
vibrant environment for biomedical research. Interested individuals should send 
their Applications, consisting of a CV, a statement of research interest, and 
three letters of recommendation, should be sent to Dr. Di Xia via Email at 
x...@mail.nih.gov



Application deadline is 4th January 2021.







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[ccp4bb] Job Opportunity- Merck Research Labs San Francisco [Confidential]

2020-04-06 Thread Chrencik, Jill 
Confidential

Would you please post to the BB:

Thank you!

Jill Chrencik
Principal Scientist
Merck Research Labs
213 E Grand Ave
South San Francisco, CA 94080



We have an exciting opportunity for a talented structural biologist in South 
San Francisco! Come be a part of our amazing team!
https://msd.wd5.myworkdayjobs.com/SearchJobs/job/USA---California---South-San-Francisco---Grand-Ave/Sr-Scientist--Structural-Biologist--X-ray-crystallography--Cryo-EM-_R47220

Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.



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[ccp4bb] Job opportunity in Berlin - HZB and Humboldt University advertise a postdoc position

2019-04-03 Thread Manfred S. Weiss 



The Helmholtz Zentrum Berlin für Materialien und Energie, the 
Max-Delbrück-Center for Molecular Medicine, the Freie Universität Berlin, the 
Chariteand the Humboldt Universität zu Berlin jointly operate three 
experimental stations for bio-macromolecular crystallography at BESSY II, one 
of the world’s most modern synchrotron radiation sources for VUV and soft 
X-rays.
(https://www.helmholtz-berlin.de/forschung/oe/np/gmx/index_en.html)

The Humboldt University zu Berlin is seeking a

Post Doctoral Research Assistant

to work on and support research topics in the field of structural enzymology 
(e.g. control of chemical reactions in macromolecular crystals, combination of 
UV/Vis absorption spectroscopy and crystallography, etc.) originating from the 
group of Prof. Dr. Holger Dobbek. The successful candidate will also be 
involved in the operation of the BESSY II bio-macromolecular crystallography 
beamlines (headed by Dr. Manfred S. Weiss) including supporting external users 
at the beamlines and will take part in graduate student education.

Initially, a contract lasting until 31.12.2020 will be offered to the 
successful candidate with the possibility for an extension. The salary will be 
based on German Federal TVöD. The position is available immediately.

Applicants should hold a Ph.D. in the biological, chemical or physical sciences 
and have a solid background in biochemical methods, in bio-macromolecular 
crystallography and/or related fields. The position also requires the 
documented ability to conduct independent research as well as excellent 
communication and interpersonal skills.

Please send applications (CV, list of publications, two references, .pdf-file 
format) citing the reference number AN/106/19 in electronic form until 
25.04.2019 to:

Dr. Manfred Weiss 
(mswe...@helmholtz-berlin.de)

Here is the link to the advertisement (in German):
https://www.personalabteilung.hu-berlin.de/de/stellenausschreibungen/wissenschaftlicher-mitarbeiter-m-w-d-befristet-bis-31-12-2020-e-13-tv-l-hu


--
Dr. Manfred S. Weiss
Macromolecular Crystallography
Helmholtz-Zentrum Berlin
Albert-Einstein-Str. 15
D-12489 Berlin
Germany



Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.

Aufsichtsrat: Vorsitzender Dr. Karl Eugen Huthmacher, stv. Vorsitzende Dr. 
Jutta Koch-Unterseher
Geschäftsführung: Prof. Dr. Bernd Rech (kommissarisch), Thomas Frederking

Sitz Berlin, AG Charlottenburg, 89 HRB 5583

Postadresse:
Hahn-Meitner-Platz 1
D-14109 Berlin



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[ccp4bb] Job opportunity with eBIC for Industry at Diamond Light Source

2018-11-26 Thread jason.van-roo...@diamond.ac.uk 
Dear all,

I would like to highlight an exciting opportunity to join our team at the 
newly-formed eBIC for Industry partnership between Thermo Fisher Scientific and 
Diamond Light Source:




eBIC for Industry is a recently inaugurated centre offering professional 
cryo-EM services to the global pharmaceutical and biotech industry. Situated at 
eBIC, a UK National Centre for cryo-electron microscopy, the partnership 
between Thermo Fisher Scientific and Diamond Light Source provides access to 
state-of-the-art microscopes, world-class experience, and the support services 
of the synchrotron environment. The density of high-end microscopes, access to 
complementary synchrotron-based techniques and the on-site manufacturer 
experience in our team makes eBIC for Industry a unique offer to the life 
science sector. We are now looking to expand the team to meet the increasing 
demand from companies wishing to apply cryo-EM methods to their challenging 
structural research questions.



This position is an opportunity to apply your cryo-EM knowledge to an array of 
projects with real-world impact on human health and great importance to the 
drug discovery business. Our team supports clients with a wide range of cryo-EM 
experience; from those first evaluating cryo-EM capabilities to those routinely 
applying the technique in their discovery pipelines. Dedicated Glacios and 
Krios G3i microscopes along with a full suite of preparation facilities and 
computing resources are at our disposal to drive client projects towards the 
atomic resolution insights they seek.



We are looking for a passionate and experienced cryo-EM structural biologist 
capable of contributing to the entire single-particle experiment from grid 
preparation to data analysis and model building. An understanding of 
structure-guided drug design and experience with protein production are also 
key to being able to consult effectively in this role. As this is a 
client-facing position you will need excellent communication skills and a 
professional service-focused outlook, along with project management and 
multitasking skills.

Further details and the link to apply can be found here: 
https://vacancies.diamond.ac.uk/vacancy/industrial-liaison-scientist-cryoem-362061.html

Best regards,
Jason van Rooyen

Jason van Rooyen, PhD
Senior Electron Microscopy Scientist
Industrial Liason Group
Diamond Light Source, Ltd.
Didcot OX11 0DE

[cid:image001.png@01D485B0.B57C5670]


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[ccp4bb] Job Opportunity at Rheos Medicines

2018-07-19 Thread Brian Albrecht 
Dear ccp4 community,

Rheos Medicines, a newly formed start-up from Third Rock Ventures, is seeking a 
structural biologist with industrial experience to join our team.  Please reply 
to the posting below – only inquiries to the posting will be responded to.

https://rheosrx.com/our-workplace/careers/associate-director-structural-biology/

Sincerely,
Brian


Title: Associate Director, Structural Biology
Department: Drug Discovery
Reports To: VP, Drug Discovery
Location: Cambridge, MA

The Company:

At Rheos, we are leading the way in the emerging field of immunometabolism to 
discover novel medicines to treat inflammatory-mediated  diseases, including 
autoimmune diseases. Our medicines control metabolic pathways of immune cells 
that influence their activation state, in order to rebalance immune responses 
that cause inflammation or autoimmunity.

The Role:

The Associate Director, Structural Biology, will provide leadership and 
expertise in the structural characterization of Rheos’s drug targets. The ideal 
candidate will be focused on protein crystallography but will integrate with 
the drug discovery organization to implement a variety of biophysical 
techniques.

Major Responsibilities:

  *   Collaborate with colleagues in lead discovery, biology, and chemistry to 
develop a structural biology strategy.
  *   Designing biophysics-grade protein constructs and assisting in the 
optimization of purification protocols.
  *   Crystallization, X-ray structure determination, and analysis of important 
drug targets through working with external collaborators.
  *   Management of external structural biology collaborations (CROs)
  *   Providing regular updates to cross-functional teams and helping guide 
structure-based compound design in close collaboration with chemistry group.

Requirements and Qualifications:

Education:

  *   PhD degree structural biology or biophysics

Required Experience:

  *   7+ years of drug discovery experience in a pharmaceutical/biotechnology 
setting;
  *   Demonstrated ability to solve difficult problems in protein 
crystallography, structural biology and biophysics
  *   Demonstrated competency in protein construct design and expression and 
purification strategies using bacterial, insect, and mammalian hosts.

Knowledge, Skills & Abilities:

  *   Strong knowledge of the drug discovery process, with deep experience in 
implementing hit identification strategies through candidate selection;
  *   Extensive knowledge of protein structure and function, with the ability 
to articulately communicate structural information to a broad audience.
  *   Experience with other structural techniques (e.g. electron microscopy, 
small-angle X-ray scattering) is preferred.

If this excites you, please submit your CV with the title of the position in 
the subject line to care...@rheosrx.com



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the delivery error by replying to this message and then delete it from your 
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information and is a private communication between the intended addressee
and Rheos

[ccp4bb] Job opportunity at GSK - Post Doc Investigator in Structural Biology

2018-07-03 Thread Enrico Malito 
Dear ccp4 community,

Here at GSK in Rockville, MD, USA, we have an opening for a Structural
Biologist/Post Doctoral Investigator with interests and experience in
vaccine research (requisition ID: WD159275). Anyone interested to apply can
do so by visiting this link:
https://careers.peopleclick.com/careerscp/client_gsk/external1931/gateway.do?functionName=viewFromLink=381834=en-us

Applications will be accepted only through the page at the link above, and
some details are provided below:

*Basic qualifications:*
• PhD in structural biology or virology plus 0-2 years of work experience
• At least one publication in a peer-reviewed journal
• Fluency in English, spoken and written
• Must be proficient in structural biology, specifically X-ray
crystallography and cryo-EM

* Preferred qualifications:*
• 2 plus years of work experience with PhD in Structural Biology
• Strong track-record of scientific publications in peer-reviewed journals,
including at least one as first author
• Experience working in structural virology and structure-based vaccine
design
• Experience with epitope mapping and prediction.
• Excellent communication and presentation skills, ability to collaborate
in multiple project work streams
• Experience in structural virology and structure-based vaccine design
strongly preferred.
Examples of relevant publications:

- Malito et al 2013. Finding epitopes with Computers.
http://dx.doi.org/10.1016/j.chembiol.2013.10.002
- Malito et al 2015. Protein Crystallography in Vaccine Research and
Development. http://dx.doi.org/10.3390/ijms160613106
- Liljeroos et al 2015. Structural and Computational Biology in the Design
of Immunogenic Vaccine Antigens http://dx.doi.org/10.1155/2015/156241
- Lopez-Sagaseta et al 2016. Self-assembling protein nanoparticles in the
design of vaccines http://dx.doi.org/10.1016/j.csbj.2015.11.001
- Lopez-Sagaseta et al 2018. Crystal structure reveals vaccine elicited
bactericidal human antibody targeting a conserved epitope on meningococcal
fHbp http://dx.doi.org/10.1038/s41467-018-02827-7
- Malito et al 2018. From recognition to execution — the HCMV Pentamer from
receptor binding to fusion triggering
https://doi.org/10.1016/j.coviro.2018.05.004

Yours sincerely,

*Enrico Malito, PhD*

Lab Head Structural Biology & Biophysics

Preclinical R US

GSK Vaccines

14200 Shady Grove Road

Rockville, MD, 20850, USA

E-mail: enrico.x.mal...@gsk.com

Mobile: +1 (202) 313 2510



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[ccp4bb] Job opportunity at Lonza Biologics, Cambridge, UK site

2018-05-14 Thread Sid Sridharan 
Dear all,

Please see below for an exciting structural bioinformatics job opportunity
at Applied Protein Services, Lonza Biologics at our Cambrigde UK site.

Kind regards,
Sid.




*Sid Sridharan, PhD *Lead Scientist
Applied Protein Services

Lonza Biologics plc
Portway Building, Granta Park
Great Abington
Cambridge, CB21 6GS, UK



The job is posted in the link below, job ref R8148



https://lonza.wd3.myworkdayjobs.com/en-US/Lonza_Careers/job/Cambridge/Senior-Scientist_R8148



   -
   Job Description Summary

   Here at Lonza we have a great opportunity available for a Senior
   Scientist to join Lonza's Applied Protein Services (APS) Bioinformatics
   team. This is a permanent position based out of our Cambridge facility.

   The Senior Scientist will work on multiple customer projects including
   antibody and protein engineering and design, antibody humanisation and
   deimmunisation and immunogenicity and protein risk assessments. In
   addition, the role will involve some system administration and programming
   to support the maintenance and development of multiple proprietary
   platforms.

   *Key Responsibilities:*
   - To perform computational antibody and protein engineering to design
  and/or modify potential biotherapeutics for customers
  - To perform *in silico*:
   - antibody humanisation and deimmunisation
  - immunogenicity risk assessments using Lonza’s proprietary EpibaseTM
  T-cell epitope prediction platform
  - developability risk assessments and antibody aggregation risk
  prediction using Lonza’s proprietary platforms
 - To perform expert sequence and structure based risk assessments
 - Program/script to support the development and maintenance of
 proprietary platforms and algorithms
 - Work in both Linux and Windows environments
 - To author high quality reports for clients and in-house
 development work
 - Share responsibility for maintenance and update of software,
 databases, systems and servers
 - To communicate project updates to internal and external clients

   *Interested?*

   *What we need you to have:*

   - PhD or equivalent experience in Bioinformatics/Structural Biology with
  a focus on computational protein engineering and modelling  , preferably
  with experience in industry
  - Demonstrate attention to detail and ensure that quality standards
  are maintained while delivering results

[ccp4bb] Job opportunity in Dundee - Drug Discovery Unit

2017-10-24 Thread David Robinson 
Hello,
 
The Drug Discovery Unit at the University of Dundee has an open position to 
join our protein production and structural biology team.
 
The Drug Discovery Unit (www.drugdiscovery.dundee.ac.uk) is a dynamic and 
multidisciplinary group of 85 scientists with expertise in compound handling, 
assay development, high-throughput screening, medicinal and computational 
chemistry and in vitro and in vivo pharmacokinetics. The unit is housed in a 
state-of-the-art building and has cutting-edge equipment and automation for 
hit-discovery and lead optimisation.
 
We are seeking an experienced and motivated protein purification scientist/ 
crystallographer to help expand our protein production capabilities and support 
structure based drug discovery projects. Protein production is carried out 
using a variety of different expression systems within our dedicated protein 
production team 
(http://www.lifesci.dundee.ac.uk/services/bcdd-protein-production). The role 
will involve construct design and development and optimisation of methods and 
protocols for protein production.
 
The role encompasses protein crystallography and will involve generating 
ligand-protein structures as part of structure-based drug discovery project and 
novel protein structures. The role holder will be expected to contribute to 
current and future structure based drug discovery projects. The successful 
candidate should have a high level of technical expertise in all aspects of 
protein scale up and protein crystallography. Knowledge of drug discovery is 
desirable but not essential.
 
 
Full particulars and application details can be found at
 
http://www.lifesci.dundee.ac.uk/vacancies/2017/oct/13/protein-purification-scientistcrystallographer
 
For informal enquires please contact Sharon Shepherd (Operations Manager 
Protein Production) smsheph...@dundee.ac.uk or David Gray 
(d.w.g...@dundee.ac.uk)
 
Closing date is November 15th 2017
 
Thanks
 
Dr David Robinson
Structural Biologist
Drug Discovery Unit
Division of Biological Chemistry and Drug Discovery
School of Life Sciences
Discovery Centre
University of Dundee

[ccp4bb] Job opportunity in Berlin - HZB and MDC advertise a postdoc position

2017-10-24 Thread Manfred S. Weiss 


The Helmholtz Zentrum Berlin für Materialien und Energie, the 
Max-Delbrück-Center for Molecular Medicine, the Freie Universität Berlin and 
the Humboldt Universität zu Berlin jointly operate three experimental stations 
for bio-macromolecular crystallography at BESSY II, one of the world’s most 
modern synchrotron radiation sources for VUV and soft X-rays.
(http://www.helmholtz-berlin.de/forschung/oe/em/soft-matter/forschung/bessy-mx/index_en.html)

The Max-Delbrück-Center is seeking a

Post Doctoral Research Assistant

to support a structure-based drug discovery project on various GTPase families 
(headed by Dr. Oliver Daumke). The successful candidate will also be involved 
in the operation of the BESSY II bio-macromolecular crystallography beamlines 
(headed by Dr. Manfred S. Weiss) and will take part in graduate student 
education.

Initially, a three-year contract will be offered to the successful candidate 
with the possibility for an extension. The salary will be based on German 
Federal TVöD. The position is available from March, 2018.

Applicants should hold a Ph.D. in the biological, chemical or physical sciences 
and have a background in bio-macromolecular crystallography, biochemistry or 
computational chemistry. The position also requires the documented ability to 
conduct independent research as well as excellent communication and 
interpersonal skills.

The MDC is an equal opportunity employer and supports gender equality.

Please send applications (CV, list of publications, .pdf-file format) in 
electronic form until 30.11.2017 to:


Dr. Manfred Weiss 
(mswe...@helmholtz-berlin.de)

and

Dr. Oliver Daumke 
(oliver.dau...@mdc-berlin.de)


--
Dr. Manfred S. Weiss
Macromolecular Crystallography
Helmholtz-Zentrum Berlin
Albert-Einstein-Str. 15
D-12489 Berlin
Germany



Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.

Aufsichtsrat: Vorsitzender Dr. Karl Eugen Huthmacher, stv. Vorsitzende Dr. 
Jutta Koch-Unterseher
Geschäftsführung: Prof. Dr. Bernd Rech (kommissarisch), Thomas Frederking

Sitz Berlin, AG Charlottenburg, 89 HRB 5583

Postadresse:
Hahn-Meitner-Platz 1
D-14109 Berlin

http://www.helmholtz-berlin.de

[ccp4bb] Job opportunity

2017-08-24 Thread Brian Mark 
Hello everyone,

I’d like to draw your attention to a job posting in the Faculty of Science, 
University of Manitoba, Canada.  We seek a technician to maintain and provide 
training on our X-ray diffraction and microscopy equipment in the faculty of 
science.  Please use the URL below to access the full job posting.

https://umanitoba.hua.hrsmart.com/ats/js_job_details.php?reqid=20906


Cheers,

Brian Mark

==
Brian Mark, MSc, PhD
Associate Professor
Department of Microbiology
& Department of Biochemistry and Medical Genetics

Mailing/Courier address:
Department of Microbiology
Rm 213 Buller Building
University of Manitoba
45 Chancellor's Circle
Winnipeg, Manitoba
CANADA R3T 2N2

Phone (204) 480-1430
Fax (204) 474-7603
Web:  http://home.cc.umanitoba.ca/~bmark/Welcome.html

[ccp4bb] Job opportunity - Structural Biology GSK Vaccines

2016-12-22 Thread Enrico Malito 
 Dear ccp4 community,

The Structural Biology Lab at GSK Vaccines, Rockville, MD, USA, is seeking
a candidate for a Scientist/Senior Scientist position (Job ID: 148543,
hiring managers: Enrico Malito, Matthew Bottomley). We offer outstanding
opportunities and compensation to outstanding candidates. Anyone interested
to apply can do so by visiting this link:
https://careers.peopleclick.com/careerscp/client_gsk/external1931/en-us/gateway.do?functionName=viewFromLink=323652=en-us
(Please note that this may wrap to another line of text; you may need to
copy and paste the entire URL into your browser window).

Applications will be accepted only through the page at the link above.

Examples of relevant recent publications:

- Rappuoli et al 2016. Reverse vaccinology 2.0: Human immunology instructs
vaccine antigen design. http://dx.doi.org/10.1084/jem.20151960
- Chandramouli et al 2015. Structure of HCMV glycoprotein B in the
postfusion conformation bound to a neutralizing human antibody
http://dx.doi.org/10.1038/ncomms9176
- Ciferri et al 2015. Antigenic Characterization of the HCMV gH/gL/gO and
Pentamer Cell Entry Complexes Reveals Binding Sites for Potently
Neutralizing Human Antibodies http://dx.doi.org/10.1371/journal.ppat.1005230
- Malito et al 2015. Protein Crystallography in Vaccine Research and
Development. http://dx.doi.org/10.3390/ijms160613106


Yours sincerely,

*Enrico Malito, PhD*




*Lab Head of Structural Biology and BiophysicsGSK VaccinesPreclinical R
USGSK Vaccines14200 Shady Grove Road, Rockville MD 20850, USA*

[ccp4bb] Job Opportunity

2016-12-01 Thread McEwan, Paul 
Dear All,
I have an opportunity for somebody to join my team in structural biology at 
Evotec. All applications must be made through our website and please address 
any questions regarding the application process to 
humanresources-abing...@evotec.com


https://jobs.newscientist.com/job/1401624324/senior-scientist-structural-biology-oxford/

https://recruitment.evotec.com/home.aspx

Best regards,
Paul..
[EvotecLogoMail]
Paul A. McEwan Ph.D.
Principal Scientist, Structural Biology
+44. (0)1235 838802
+44. (0)1235 863139 (Fax)
paul.mce...@evotec.com
www.evotec.com

Evotec (UK) Ltd.
114 Innovation Drive
Milton Park
Abingdon
Oxfordshire
OX14 4RZ  (United Kingdom)


STATEMENT OF CONFIDENTIALITY.

This email and any attachments may contain confidential, proprietary, 
privileged and/or private information.  
If received in error, please notify us immediately by reply email and then 
delete this email and any attachments from your system. Thank you!


Evotec (UK) Ltd is a limited company registered in England and Wales. 
Registration number:2674265. Registered office: 114 Innovation Drive, Milton 
Park, Abingdon, Oxfordshire, OX14 4RZ, United Kingdom.

[ccp4bb] Job opportunity in Shanghai

2014-09-12 Thread jianhua_cai 
Dear colleagues,   

Viva Biotech, located in Shanghai, is specialized in structure-based drug 
discovery providing preclinical drug discovery research services to global 
pharmaceutical and biotech companies. We have opening for program leader in 
structural biology and biochemistry. Anyone who is interested in the position  
please send CV to jin@vivabiotech.com.   

Job title: group leader in structural biology or biochemistry

Job description

We are seeking a highly motivated individual with experience in protein 
biochemistry and structural biology. Candidates will lead the structural 
biology team to carry out the biochemistry studies and/or gene-to-structure 
studies which elucidate the interactions between small molecules/peptides and 
their targets. Experiences with protein expression and purification, excellent 
interpersonal and managerial skills, team player with excellent written and 
verbal communication skills and proficiency in structure biology related 
software. Excellent communication skill in English; 3-5 years working 
experiences with in US or Europe.

Qualifications

1)  Ph.D. in crystallography or protein biochemistry training with minimal 
3-5 years’ working experience 

2)  Hands-on experience in protein crystallization, and protein expression 
and purification is optional. 

3)  Proficient in structure biology related software is plus. 

4)  Demonstrated managerial skill to guide groups through corporate change 
and growth. 

5)  Excellent verbal and writing skills in English are essential.

6)  Strong communication skills and client interaction are required.


Jianhua

[ccp4bb] Job opportunity - Research Complex at Harwell

2014-09-08 Thread Stephen Carr 
Dear BB,

We have a opening for a post-doctoral scientist at the Research Complex at 
Harwell.



IRC157933: Post-Doctoral Research Scientist (Fixed Term until 28/02/2016)

Salary: £27,084 - £32,324 per annum

Research Complex at Harwell


We are looking for an individual who can help us with the delivery of high 
quality original research on the structure and function of proteins and 
protein-DNA complexes involved in the resolution of Holliday junctions and 
other branched DNA structures.


The sucessful candidate would be expected to:


  *   Perform high quality research on the structural biology of Holliday 
junction resolution, including production and purification of proteins and DNA, 
crystallisation and crystal structure determination of protein-DNA complexes 
and the use of other biophysical techniques such as small angle X-ray and 
neutron scattering, electron microscopy etc. as required.

  *   Be an active member of the Holliday junction research group and 
contribute to group meetings, formulation of research strategies etc.

  *   Write and publishing research papers on the results of the work and also 
presenting the results of the work at conferences.


The appointment is based at the Research Complex at Harwell (RCaH), a 
state-of-the-art multidisciplinary laboratory that provides facilities for 
researchers to undertake new and cutting edge scientific research in both life 
and physical sciences and the interface between them. More information is 
available at www.rc-harwell.ac.ukhttp://www.rc-harwell.ac.uk/



To join us you will need:

  *   A PhD in Biochemistry, a biological or physical science subject or 
equivalent.

  *   Laboratory experience carrying out original research in structural and / 
or molecular biology.

  *   PhD or post-doctoral experience in protein purification, crystallisation 
or structure determination.

  *   Excellent interpersonal and communication skills (both oral and written).

  *   Ability to communicate research results, including presentations at 
conferences and publication of original papers.

  *   Familiarity with software packages for protein structure analysis and 
molecular graphics.

  *   The ability to generate ideas, analyse options, prioritise and make 
effective decisions.


We are looking for a flexible individual who can adapt to need and circumstance 
and is ready for a challenge.


Benefits include generous holiday entitlement and an excellent contributory 
final salary pension scheme.


For an informal discussion about the role please contact 
stephen.c...@rc-harwell.ac.uk.


Applications are handled by the UK Shared Business Services; to apply please 
visit our job board at www.topcareer.jobshttp://www.topcareer.jobs, and 
upload your CV along with a Cover Letter (when saving your documents quote 
IRC157933 in the filename). Applicants who would like to receive this advert in 
an alternative format (e.g. large print, Braille, audio or hard copy), or who 
are unable to apply online should contact us by telephone on 01793 867000 and 
quote reference number IRC157933 when calling.


Closing date: 28th September 2014

The MRC is an Equal Opportunities Employer

Final appointments will be subject to a pre employment screening


Dr Stephen Carr
Research Complex at Harwell (RCaH)
Rutherford Appleton Laboratory
Harwell Oxford
Didcot
Oxon OX11 0FA
United Kingdom
Email stephen.c...@rc-harwell.ac.uk
tel 01235 567717
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privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorized recipient of the addressee, 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to this email.

Any views or opinions presented are solely those of the author and do not 
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[ccp4bb] Job opportunity at Constellation pharmaceuticals in Cambridge MA

2014-03-05 Thread Steve Bellon 
Constellation Pharmaceuticals has the following job opportunity.  Please use 
the 'care...@constellationpharma.com' email to reply.

Scientist - Structural Biology
Constellation Pharmaceuticals leverages insights from the rapidly expanding 
field of epigenetics to discover and develop small molecule therapeutics for 
the treatment of cancer, inflammatory/immunologic disorders and other diseases. 
Research here and by others has shown that abnormal epigenetic regulation of 
gene expression contributes to many different diseases. Our innovative product 
discovery engine targets both the enzymes that modify the dynamic structure of 
chromatin and other proteins that interact with chromatin to control gene 
expression.
The Structural Biology Department at Constellation is looking for a Scientist 
level candidate to join our team and contribute to our drug discovery efforts. 
This position requires a passion to do high quality scientific research in a 
collaborative, goal-oriented and fast-paced team environment.
The primary responsibilities of this role include (but are not limited to) 
conducting laboratory experiments related to all aspects of crystallography 
from crystal growth to structure solution, analyzing, and interpreting 
scientific data, collaborating with other scientists, and performing 
computer-assisted structure based drug design.
The ideal candidate will have a background in chemistry and an in-depth 
understanding of target/ligand interactions.   We require 2-5 years of 
post-doctoral experience, and industrial experience (in pharmaceutical or 
biotech) will be considered a plus.  A strong commitment to frequently and 
articulately communicate structural information to colleagues in chemistry, 
enzymology and biology is expected.

Constellation Pharmaceuticals is an Equal Opportunity Employer and a 
participant in E-Verify, and offers a comprehensive benefits package, including 
health, dental, 401(k), paid vacation, tuition reimbursement, and much more.

If you are interested in joining Constellation's team please submit your resume 
to the following address: care...@constellationpharma.com



This email message and any attachments are being sent by Constellation 
Pharmaceuticals, Inc. The information contained in this e-mail message, and any 
attachments, may contain information that is confidential or privileged. If you 
are not the intended recipient, any dissemination or copying of this 
communication is strictly prohibited. If you have received this communication 
in error, please notify the sender immediately by return e-mail and destroy all 
copies of this message and any attachments. Thank you.

For more information about Constellation, please visit us at 
http://www.constellationpharma.com.

[ccp4bb] Job opportunity in Drug Discovery, Glasgow, UK

2013-06-25 Thread Chris Gray 
The Beatson Institute for Cancer Research
Drug Discovery Programme
Glasgow
UK

Scientist, Protein Crystallography
Competitive Benefits Package

The Beatson Drug Discovery Programme is an industry standard unit at the 
cutting edge of drug discovery. Exploiting the basic biology strengths within 
the Beatson Institute and wider Cancer Research UK network, the programme 
targets some of the most exciting and challenging cancer targets. Central to 
our strategy is Fragment-Based Drug Discovery methods and we use NMR and 
Surface Plasmon Resonance as primary tools for fragment-based hit 
identification. In addition, we also use X-Ray crystallography as a key 
component of our Structure-Based Drug Design approach towards discovering novel 
drug molecules.

We are seeking a highly motivated and talented scientist who will participate 
in crystallisation and x-ray structure solution of key protein targets. You 
will be a protein crystallographer with some experience who may have recently 
completed a productive Ph.D. in structural biology.  Experience in automated 
crystallisation methods, synchrotron data collection and the solving of small 
molecule-protein complex structures would be an advantage. The successful 
candidate will have a creative approach to problem solving, good interpersonal 
skills and be comfortable working in a dynamic environment.  In return, you 
will receive a competitive benefits package commensurate with your skills and 
experience and find at the Beatson, an inspiring, supportive and creative 
atmosphere where your contribution really will make a difference.

Applications with covering letter, CV and names of three referees should be 
sent to: Dr Christopher H Gray, Drug Discovery Programme, The Beatson Institute 
for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 
1BD or by email to c.g...@beatson.gla.ac.uk

Closing date for applications is August 2nd, 2013.

[ccp4bb] Job Opportunity at Rigaku Automation

2013-01-10 Thread Mark Benson 
Hello

My colleagues at Rigaku Automation based in Carlsbad, California are looking to 
recruit a Research Scientist.  Please feel free to forward to anyone in your 
group who may be interested.

Information on Rigaku Automation and its products can be found here: 
http://www.rigakuautomation.com

Research Scientist  – Protein Crystallization / Protein Crystallography

Rigaku Automation is a premier provider of lab automation equipment to 
structural biology labs worldwide, specializing in protein crystallization. 
Looking for an equally motivated and experienced protein crystallographer to 
join our team in Carlsbad, CA USA. Full benefits package. Send resume to 
raij...@rigaku.commailto:raij...@rigaku.com



Essential Duties and Responsibilities (Additional duties may be assigned.)

· Contribute to the design, development, and testing of new lab 
automation products.

· Perform experiments that illustrate and exemplify the needs of the 
scientific community.

· Act as a scientific advisor to the company by evaluating novel 
scientific methods in terms of their potential to define new products or by 
conducting experiments that drive enhancements of existing ones.


Qualifications

· Ph.D. in protein crystallography; work experience outside academia 
strongly preferred.

· Proven experience with lab automation and detailed knowledge on lab 
workflows and research methodologies, especially in relation to protein 
crystallization.

· Demonstrated ability to work in team environments and impact 
collaborative efforts by independent, creative, scientific thinking.

· Excellent communicator and ability to present and document scientific 
findings and thought processes.

Informal enquiries can be made to Alice Sorensen: 
alice.soren...@rigaku.commailto:alice.soren...@rigaku.com

Thanks

Mark
Rigaku Europe

[ccp4bb] Job opportunity: Postdoctoral researcher

2012-04-19 Thread Mark Banfield (JIC) 
Dear CCP4BBers,


I'd like to bring to your attention a post-doctoral research assistant 
opportunity available in the Banfield Laboratory at the John Innes Centre in 
Norwich, UK.


We primarily study protein structure/function relationships important in the 
co-evolutionary arms race between plant pathogens and their hosts, with a 
particular emphasis on oomycetes such as the Irish potato famine pathogen 
Phytophthora infestans. This parasite continues to be a very serious problem 
for modern agriculture. Ultimately, in addition to making exciting fundamental 
discoveries, we expect our studies to drive development of novel methods for 
disease control.


The current opportunity would suit a post-doctoral level researcher interested 
in the molecular mechanisms that underpin microbial pathogenesis. The project 
will involve determining the structures of pathogen and host proteins alongside 
in vitro biochemical/biophysical interrogation of interactions, 
discovery/validation of protein activities and in planta studies (training 
available).


For further details of the position, and how to apply (deadline 7th May), 
please see: http://bit.ly/IGCP6P


Informal enquiries to me are welcome, but please apply through the appropriate 
JIC links.


Mark


--
Dr Mark J Banfield
Dept. of Biological Chemistry
John Innes Centre
Norwich Research Park
Norwich
NR4 7UH
UK
email: mark.banfi...@jic.ac.uk
tel: +44 (0)1603 450742
fax: +44 (0)1603 450118
twitter: @mjbanfield1973

[ccp4bb] job opportunity in molecular biophysics / structural biology

2012-02-10 Thread Weiergräber, Oliver H. 
Dear colleagues,

I would like to point your attention to the following job opportunity - 
professorship/director (W3) - which is jointly offered by the Forschungszentrum 
Juelich and Heinrich Heine University Duesseldorf, Germany:

http://www.nature.com/naturejobs/science/jobs/243931

The focus of his/her work will be on the application and development of modern 
cryo-electron microscopy in biology and biomedicine. Deadline for applications 
will be March 30, 2012.

Best regards
Oliver



  PD Dr. Oliver H. Weiergräber
  Institute of Complex Systems
  ICS-6: Structural Biochemistry
  Tel.: +49 2461 61-2028
  Fax: +49 2461 61-1448


---
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Forschungszentrum Juelich GmbH
52425 Juelich
Sitz der Gesellschaft: Juelich
Eingetragen im Handelsregister des Amtsgerichts Dueren Nr. HR B 3498
Vorsitzender des Aufsichtsrats: MinDir Dr. Karl Eugen Huthmacher
Geschaeftsfuehrung: Prof. Dr. Achim Bachem (Vorsitzender),
Karsten Beneke (stellv. Vorsitzender), Prof. Dr.-Ing. Harald Bolt,
Prof. Dr. Sebastian M. Schmidt
---
---

Kennen Sie schon unsere app? http://www.fz-juelich.de/app

[ccp4bb] Job opportunity at the Australian Synchrotron

2012-01-12 Thread Christine Gee 
Dear CCP4 readers
There is currently an opening on the MX beamlines at the Australian 
Synchrotron.  For the full job information consult the link below.
Regards
Christine

http://www.synchrotron.org.au/index.php/about-us/working-at-the-synchrotron/employment-opportunities/699-science-research-officer

[ccp4bb] Job Opportunity - Head of the Berkeley Center for Structural Biology

2011-12-04 Thread Paul Adams 
The Physical Biosciences Division at Lawrence Berkeley National Laboratory is 
seeking candidates for the Head of the Berkeley Center for Structural Biology. 
This position provides scientific, technical and operational oversight of the 
BCSB at the Advanced Light Source (ALS), a third generation synchrotron 
facility. The BCSB is a user resource for structural biology experiments and 
consists of 5 beamlines at 2 sectors of the ALS, with a staff of 16. This Staff 
Scientist position will provide leadership and direction to develop methodology 
and instrumentation for collecting and analyzing crystallographic data using 
synchrotron radiation, and on projects involving the structure determination of 
biological molecules using X-ray crystallography. This position focuses on the 
field of crystallography, and involves interactions and collaborations with 
researchers from multiple scientific disciplines including chemistry, 
crystallography, biochemistry, biology, physics and computational sciences. 

For full details please visit the job application link at:

https://lbl.taleo.net/careersection/2/jobdetail.ftl?lang=enjob=73970

Lawrence Berkeley National Laboratory is a world leader in science and 
engineering research, with 13 Nobel Prize recipients over the past 75 years. 
LBNL conducts unclassified research across a wide range of scientific 
disciplines and hosts four national user facilities. AA/EEO employer committed 
to the development of a safe and diverse workforce. Learn more about the Lab at 
http://www.lbl.gov.

-- 
Paul Adams
Deputy Division Director, Physical Biosciences Division, Lawrence Berkeley Lab
Division Deputy for Biosciences, Advanced Light Source, Lawrence Berkeley Lab
Adjunct Professor, Department of Bioengineering, U.C. Berkeley
Vice President for Technology, the Joint BioEnergy Institute
Laboratory Research Manager, ENIGMA Science Focus Area

Building 64, Room 248
Tel: 1-510-486-4225, Fax: 1-510-486-5909
http://cci.lbl.gov/paul

Lawrence Berkeley Laboratory
1 Cyclotron Road
BLDG 64R0121
Berkeley, CA 94720, USA.

Executive Assistant: Louise Benvenue [ lbenve...@lbl.gov ][ 1-510-495-2506 ]
--

[ccp4bb] Job opportunity

2011-04-29 Thread ferrer 








Hi, 

Here is a position in a company in the
US for a protein crystallographer.

JL

-- 
Jean-Luc Ferrer
|---|
|Institut de Biologie Structurale J.P. Ebel CEA/CNRS/UJF|
|41 rue Jules Horowitz - 38027 Grenoble cedex 1 - FRANCE|
|tel.: +33 (0)4-38-78-59-10 - fax : +33 (0)4-38-78-51-22|
|---|


NatX-ray LLC (www.natx-ray.com),
a start-up company specializing in automated systems and consumable
products for crystallography laboratories has an opening for a
full-time Sales Position in San Diego, California.
For this position,a PhD in
Protein Crystallography or equivalent is preferred, as well as an
interest in marketing and sales. Candidate must also have a
high level of enthusiasm, motivation and be able to work
independently.
Compensation: Base salary based on
experience, plus a pre-determined % commission on sales.
For further information (job
description) or for interested candidates please e-mail cover
letter/resume to: cont...@natx-ray.com

[ccp4bb] job opportunity: protein expression scientist, Glasgow UK

2010-04-12 Thread Andrew Pannifer 
 

Please direct applications to the email address below.

Thanks,

Andrew

 

 

 Protein Expression Scientist 

Starting Salary: £22,100 to £37,100 depending on experience 

The Beatson Institute Drug Discovery Programme will become established as an 
Industry Standard Unit, exploiting world class research within the Beatson 
Institute, the Cancer Research UK network and beyond to discover novel 
anticancer therapies. Fragment screening by NMR and SPR, structure-based design 
and high throughput assay will be critical to success. 

We are seeking an experienced protein expression scientist to design and 
execute protein expression and purification strategies to enable in vitro 
screening, structural biology, NMR and biophysical methods. 

Duties and Responsibilities: 

*Vector design and cloning in E.coli and baculovirus expression systems, 
coordination of external gene synthesis requests. 

 

*Expression and purification in milligram quantities of protein for 
crystallisation, NMR, biophysical methods and in vitro assays 

 

*Efficient maintenance of SOPs and lab book records 

 

Qualifications and Experience/Skills 

*BSc/MSc in a biological science with a minimum of 3 years hands-on experience 
of cloning, expression and purification or a relevant PhD with a minimum of 2 
years experience as described. 

 

*Familiarity with requirements of SPR, NMR (including expression of labelled 
proteins) and protein crystallisation would be an advantage as would 
crystallisation experience. 

 

*Good communication and teamworking skills 

 

*Ability to coordinate multiple projects in parallel 

 

Applications with CV and names of three referees should be sent to Drug 
Discovery Programme, The Beatson Institute for Cancer Research, Garscube 
Estate, Switchback Road, Bearsden, Glasgow, G61 1BD or by email to 
beat...@beatson.gla.ac.uk 

Closing date for applications is 30 April 2010.

[ccp4bb] Job opportunity in structure-based ligand design in Dundee (UK)

2010-03-24 Thread Ruth Brenk 

Hi,

I have a job opportunity for a highly motivated individual in the area
of structure-based ligand design design in my group.

Check out our University web page for more information about the job and
on how to apply
(http://www.jobs.dundee.ac.uk/vacancies/20100407_1-y.html).

Cheers

Ruth



--
Dr. Ruth Brenk
Biological Chemistry and Drug Discovery
College of Life Sciences
University of Dundee
Dow St.
Dundee, DD1 5EH
U.K.
+44 (0)1382 386230 (phone)
+44 (0)1382 386373 (fax)
http://www.brenkgroup.dundee.ac.uk
http://www.lifesci.dundee.ac.uk/people/ruth_brenk/

The University of Dundee is a registered Scottish charity, No: SC015096.

[ccp4bb] Job opportunity: Systems Specialist II - Automation, Protein Crystallography

2009-01-30 Thread Mitch Kocen 
For more than 30 years, Genentech has been at the forefront of the
biotechnology industry, using human genetic information to develop novel
medicines for serious and life-threatening diseases. Today, Genentech is
among the world's leading biotech companies, with multiple therapies on
the market for cancer and other serious medical conditions. Please take
this opportunity to learn about Genentech, where we believe that our
employees are our most important asset.

The following opportunity exists in our South San Francisco, CA,
headquarters: 

 

Systems Specialist II - Automation, Protein Crystallography

 

Responsibilities:

We are seeking a highly collaborative and mechanically adept individual
to join the Genentech protein crystallography group, consisting of
approximately 20 scientists, research associates, and postdoctoral
fellows engaged in structure determination of proteins and
protein-ligand complexes of therapeutic interest. The successful
candidate will have primary responsibility for maintaining and improving
our in-house X-ray crystallography facility, which currently consists of
X-ray generators and detectors, automated crystal imaging systems, and
robotic crystallization equipment. The individual will be the primary
contact for vendor-assisted troubleshooting and will perform daily and
preventative maintenance. The individual will have the opportunity to
collaborate on diverse projects by assisting with in-house data
collection.

 

Requirements:

This position requires a Bachelor's degree in Engineering, Physics, or a
relevant discipline and three years of experience in an industrial or
crystallography/automation environment. Practical mechanical aptitude
and attention to detail are required. Experience in troubleshooting
robotic equipment and/or X-ray equipment is preferred. Experience in
computer programming and X-ray software is a plus. Strong teamwork,
collaboration and communication skills are essential.

 

Genentech is dedicated to fostering an environment that is inclusive and
encourages diversity of thought, style, skills and perspective. Do not
reply to this e-mail. To learn more about our current opportunities,
please visit: http://careers.gene.com and reference Req. #126110.
Please use Web - CCP4 when a source is requested. Again, please do not
reply to this e-mail. Genentech is an Equal Opportunity Employer.

[ccp4bb] Job opportunity

2008-02-13 Thread Barnett, Jim 

The Protein Sciences Group of Roche Palo Alto is seeking a Protein
Chemist.


 


The Position:


The Protein Sciences group at Roche Palo Alto is seeking a Protein
Chemist for purification and characterization of membrane proteins (such
as GPCRs and Ion-Channels). The successful candidates will interact with
the Molecular Biology Group, the Protein Structure Group, the Screening
Group and Molecular Pharmacologists to insure that the purified proteins
can be successfully utilized in our drug discovery efforts. Automated,
high throughput technologies will be employed, where appropriate, so
that the best recombinant expression systems and purification conditions
can be identified expeditiously. 


 


Who you are:


A BS/MS with 5 years experience in an industrial or academic laboratory
and a proven track record in membrane protein purification or a Ph.D
with 2 years postdoctoral experience in membrane protein biology is
required. In addition to experience purifying and characterizing
proteins the successful candidate should have an aptitude for automated,
high throughput robotics that will be used to develop optimal
purification methods.

 

If you are interested in learning more about Roche  and to apply  for
this position on-line, please visit our career website at
paloalto.roche.com
file:///C:\Documents%20and%20Settings\barnettj\Local%20Settings\Tempora
ry%20Internet%20Files\OLK11E\paloalto.roche.com .

 

Roche is an Equal Opportunity Employer

[ccp4bb] Job opportunity at Vertex Pharmaceuticals

2007-04-02 Thread Graham Cheetham 
Vertex Pharmaceuticals
X-ray Crystallography - Research Scientist 

Employer - Vertex Pharmaceuticals
Location - Thames Valley, Oxfordshire
Job title - X-ray Crystallography - Research Scientist 

Vertex Pharmaceuticals Inc. is a global biotechnology company committed to 
the discovery and development of breakthrough small molecule drugs for 
serious diseases. The Company's strategy is to commercialise its products 
both independently and in collaboration with major pharmaceutical 
companies. In addition to our two marketed drugs we have a strong pipeline 
of clinical programs principally focused on viral diseases, inflammation, 
autoimmune diseases and cancer. Vertex has a well-equipped and 
highly-productive structural biology group in the UK, which contributes in 
real time to our medicinal chemistry optimisation programs, evaluation of 
new drug targets and elucidation of biological mechanism
New in-house crystallography initiatives and access to state-of-the-art 
synchrotron radiation offer significant opportunities for enhancing our 
capability in the UK. Therefore, we are looking for a highly-motivated 
team player who can make a strong contribution in a dynamic scientific 
environment where chemists, biologists, computational chemists and 
structural biologists work closely together
You should have recently obtained a PhD in crystallography and have 
demonstrated expertise in data collection, preferably using synchrotron 
X-radiation, and state-of-the-art computational methods for structure 
solution and refinement
Although drug discovery expertise is not a prerequisite, experience of 
working with membrane proteins is an advantage. A good communicator, able 
to work with scientists from different disciplines, you will be flexible, 
bright and inventive
Please send your CV and covering letter, clearly marked Research Scientist 
via e-mail to: [EMAIL PROTECTED]
Closing date: 30th April 2007
Agencies are kindly requested to refrain from contact
Vertex Pharmaceuticals Inc. is an Equal Opportunity Employer
http://www.vrtx.com

[ccp4bb] Job opportunity at the Structural Genomics Consortium

2007-03-23 Thread Declan Doyle 
A great opportunity is on offer to work on one of the most exciting areas of 
structural biology - that of integral membrane proteins with a focus on ion 
channels and transporters.

Position Title: Postdoctoral Scientist - Membrane Receptor Signalling Group
Grade:  Salary scale for University Staff Grade 7: *25,889 - *31,840 
p.a.
Working to: Senior Scientist/Team Leader Structural Biochemistry and to the 
Principal Investigator, Biology 2 Team at the Structural Genomics Consortium
Location:   Based at the Botnar Research Centre at the Nuffield 
Orthopaedic Centre

Key objectives:

Protein expression, purification, characterization and crystallization of 
integral membrane proteins within the Structural Biochemistry Team in Biology 
Division within the UK arm of the Structural Genomics Consortium. 

Background:

The Structural Genomics Consortium (SGC) is an international 
UK-Canadian-Swedish collaboration whose primary objective is to determine the 
3-dimensional structures of human and malaria proteins and release them into 
the public domain. The SGC is funded by the Wellcome Trust, a group of Canadian 
and Swedish funding agencies and GlaxoSmithKline. Since its establishment in 
2003 (the Swedish node added in 2004) it has built the infrastructure and 
technology platforms to determine the structures of ~200 proteins of medical 
relevance per year. The current Phase of funding for SGC Oxford ends in June 
2008. The application for renewal of the grant until June 2011 is currently 
under review. 

The SGC is one of the largest high throughput structural biology projects in 
the world, operating from three sites, one at the University of Toronto, one at 
the Karolinska University in Stockholm and one at the University of Oxford 
based at the Botnar Research Centre, which is located at the Nuffield 
Orthopaedic Centre in Headington, Oxford. All three sites have independent yet 
coordinated activities reflecting the scientific expertise and environment at 
each site. The Oxford site currently targets oxidoreductases, metabolic 
enzymes, kinases, phosphatases, G proteins and signalling components that are 
involved in human disease. A growing emphasis lies on transmembrane proteins.

The SGC Chief Executive, Dr Aled Edwards, has overall responsibility for 
implementation of the activity and is required to report quarterly to the Board 
of Directors (via the Chairman). Board members determine the strategic 
direction, milestones and administer the budget. The Chief Scientists, Dr 
Johann Weigelt, Dr Michael Sundstrom and Dr Cheryl Arrowsmith are coordinating 
the Stockholm, Oxford and Toronto operations, respectively. The Oxford site 
currently consists of ~65 staff members. For more information see: 
http://www.sgc.ox.ac.uk/.


Main duties:

1.  To participate in the scientific and technical activities of a 
structural biochemistry team within the SGC.

2.  Under supervision, perform independent research within the Structural 
Biochemistry Team.

3.  To work with the Senior Scientist of the Structural Biochemistry Team 
toward the goals set for the Biology Division and the Structural Genomics 
Consortium.

4.  To express, purify, characterize and crystallize integral membrane 
proteins on the SGC *priority list*.

5.  To gain excellent skills in all aspects of Structural Biochemistry as 
defined above (4).

6.  To establish excellent working relations within the Biology divisions 
and other divisions of the SGC.

7.  To demonstrate excellent scientific skills and actively contribute to 
scientific publications of key results. 

8.  To carry out any other relevant duties as may reasonably be associated 
with the post and which may be required from time to time.


Person Specification

Essential Criteria:

*   Good scientific publication record
*   Proven experience in at least 2 of the following areas: protein 
production, purification, characterization, crystallization, and structure 
determination.
*   PhD in a relevant area of protein science and biochemistry relating to 
integral membrane protein families preferably ion channels, transporters or 
other family members of biomedical importance.
*   Ability to function well as part of a team.
*   Demonstrate integrity, enthusiasm, motivation, flexibility and 
confidence 


Application Procedure

Application form can be found at http://www.sgc.ox.ac.uk/jobs/07021.html 
Completed applications should be sent to the Personnel Administrator, Room 
5802, Nuffield Dept of Clinical Medicine, John Radcliffe Hospital, Oxford, OX3 
9DU or e-mail to [EMAIL PROTECTED]  Please quote the reference HB-07-021-SGC. 
The closing date for applications is Friday 13 April 2007.


- - - - - - - - -

Declan Doyle



PI Membrane Receptor Signalling Group
Structural Genomics Consortium
University of Oxford,
Botnar Research Centre,
Oxford OX3 7LD.

www.sgc.ox.ac.uk 
Tele: 01865 227970
Fax:  01865 737231