[ccp4bb] Post-doc position in protein crystallography, epigenetics and drug discovery at the City of Hope

[Jeff Perry]

Hi,

We currently have a Postdoctoral Fellowship position open in protein 
crystallography and drug discovery as a joint position in the labs of Dr. 
Jianjun Chen, Chair of Department of Systems Biology and Dr. Jeff Perry, 
Assistant Professor in the Department of Molecular Diagnostics and Experimental 
Therapeutics, at City of Hope Medical Center in Los Angeles, California. 

The research is focused on fragment, and small molecule-based drug discovery 
approaches against RNA/DNA epigenetic targets, RNA methylation and 
post-transcriptional regulation, and includes determining structures of 
fragment, RNA probe, and small molecule:protein target co-complexes and using 
biophysical approaches, including thermal shift assays, isothermal calorimetry 
and/or surface plasmon resonance.  

For consideration, please send a single PDF that includes your CV, a cover 
letter briefly highlighting your previous research accomplishments and future 
research goals, and contact information of three scientific mentors 
(references) to Dr. Jianjun Chen at jianc...@coh.org and Dr. Jeff Perry at 
jpe...@coh.org.

Thanks,

Jeff Perry, Ph.D.
Assistant Professor,
City of Hope



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[ccp4bb] Post-doc position in protein crystallography and drug discovery at the City of Hope

[Jeff Perry]

Dear All,

I have a post-doctoral position in protein crystallography and drug discovery 
is available in my laboratory at the City of Hope Medical Center in Los 
Angeles, California. The project is an NIH funded collaborative effort, 
coupling cell biology, chemistry and structural biology for novel inhibitor 
design.

If interested, kindly send your cover letter and CV to me at: jpe...@coh.org

Jeff Perry, Ph.D.
Assistant Professor,
Monrovia, CA 91016
cityofhope.org/jeff-perry-lab



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[ccp4bb] Post doc position at the Astbury Centre, University of Leeds, UK

[Joseph Cockburn]

Dear all,

We have a 3-year postdoc position to work on a highly interdisciplinary project 
to study the structure and dynamics of ciliary proteins, in collaboration with 
Dr George Heath, Prof. Colin Johnson and Prof. Michelle Peckham. Please don't 
hesitate to contact any of us for more details!

To apply for this role please go to:
https://jobs.leeds.ac.uk/Vacancy.aspx?ref=FBSMB1274

Deadline for applications: 05th March 2024.

Kind regards,

Joe


--
Dr Joseph J B Cockburn DPhil
Program Leader, Biochemistry and Medical Biochemistry
Group Leader and Lecturer in X-ray Crystallography
The Astbury Centre for Structural and Molecular Biology
School of Molecular and Cellular Biology
Faculty of Biological Sciences
University of Leeds
Leeds LS2 9JT
UK
+44 (0)113 3430758

Sometimes I need to send emails in the evenings or at weekends, but I don’t 
expect a reply outside of your normal working hours.




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[ccp4bb] Post Doc position at QMUL

[Aravindan Ilangovan]

Dear All

We are looking for a post-doctoral research associate with expertise in 
cryo-EM/cryo-ET to join our research group in the Centre for Molecular Cell 
Biology at Queen Mary University of London. This Wellcome Trust funded post 
will work towards understanding the molecular mechanism of DNA replication 
initiation in bacteria. This structural biology project will take advantage of 
the expertise in the lab working with nucleoprotein complexes aided by 
dedicated cryo-EM facility. The group has routine access to the Titan Krios 
microscopes at LonCEM and eBIC and an in-house computing infrastructure for 
data processing.


Details about the position and a link to the application system can be found 
here



https://www.qmul.ac.uk/jobs/vacancies/items/9305.html



Feel free to contact me (a.ilango...@qmul.ac.uk) 
if you have any specific queries about this post.



Best

Aravindan

Aravindan Ilangovan
Abernethy building | QMUL
Whitechapel
London | E1 2AT

www.ilangovan-lab.com/





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[ccp4bb] Post-doc position in structural biology of viral protein trafficking

[Hasan, Syed Saif]

Dear Colleagues,


An NIH-funded post-doctoral research position is available immediately in our 
lab at the University of Maryland 
(https://sites.google.com/view/viralglycoproteintrafficking/). We apply single 
particle cryoEM, X-ray crystallography, and biophysical approaches to 
investigate how the interactions between viral and host proteins are 
coordinated during intracellular trafficking (see Nature Communications (2023, 
PMID: 38102143), Protein Expression and Purification (2023, PMID: 37625737), 
and Communications Biology (2022, PMID: 35136165)). Our long-term goal is to 
use this fundamental information to design new genetic vaccines against 
existing and emerging diseases. We collaborate extensively with leading 
research groups in cell biology, mass spectrometry, NMR, protein modeling, 
immunology, and virology, as is evident from our publications.


We are looking for expertise in either X-ray crystallography or single particle 
cryoEM. Prior experience in protein production, mammalian cell culture, and BLI 
assays will be a major advantage. Candidates who have recently completed their 
PhD are especially encouraged to apply. Interested candidates should email me a 
CV and a list of three professional references at 
ssha...@som.umaryland.edu. I am happy to 
answer any questions about this position, the work environment, the resources 
at our disposal, and of course, the many things to do in this area.

Why you should join us-

  *   Our lab is in the Institute for Bioscience and Biotechnology Research 
(IBBR), Rockville MD, which is home to over 20 structural biology research 
groups from the University of Maryland and the National Institute of Standards 
and Technology.
  *   IBBR provides state-of-the-art instrumentation in cryoEM (200 kV Talos 
Arctica and Glacios with K3 and Falcon IV detectors, Volta phase plate, and a 
Selectris energy filter), and on site facilities for BLI assays, NMR, and 
cluster-based computation.
  *   We are in the I-270 Life Sciences Corridor, which is a top innovation 
cluster in the nation. This location gives us close access to partners in 
biotechnology and pharmaceutical companies, nearby universities, and federal 
labs such as from the NIH system, which is 11 miles from IBBR. This proximity 
fosters collaborations and provides employment opportunities.
  *   Our post-doc program is focused on mentorship and career advancement that 
meet the candidate’s goals.
  *   Rockville is well connected by public transport to Washington DC (20 
miles) and we have good access to three major airports- Dulles International 
Airport (26 miles), Ronald Reagan Washington National Airport (25 miles), and 
Baltimore/Washington International Airport (42 miles).

The University of Maryland is an Equal Opportunity, Affirmative Action 
employer. Minorities, women, individuals with disabilities and protected 
veterans are encouraged to apply.

Saif (pronunciation: https://www.youtube.com/watch?v=amT4vLiJOJA)

S. Saif Hasan, PhD
Assistant Professor, Department of Biochemistry and Molecular Biology, 
University of Maryland School of Medicine
Associate Member, Program in Oncology, University of Maryland Marlene and 
Stewart Greenebaum Comprehensive Cancer Center
Office and Laboratory Address
Center for Biomolecular Therapeutics, Institute for Bioscience and 
Biotechnology Research (IBBR)
9600 Gudelsky Drive, Rockville MD 20850
Phone: 240-314-6396
Fax: 240-314-6225
https://www.medschool.umaryland.edu/profiles/Hasan/
https://www.ibbr.umd.edu/profiles/s-saif-hasan
https://sites.google.com/view/viralglycoproteintrafficking/



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[ccp4bb] Post-doc position(s) at University of Colorado

[Shi Celine]

Dear all,

Applications are invited for a fully funded postdoctoral position in the 
laboratory of Ning Zhao in University of Colorado Anschutz Medical Campus 
(https://medschool.cuanschutz.edu/biochemistry/people/primary-faculty/zhao-ning).
 Please find enclosed the job description in the attachment. CVs (including 
publication list and reference names) and queries should be sent to:  
ning.z...@cuanschutz.edu

Best wishes

Shasha Shi



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Postdoc positions in Dr. Ning Zhao lab.pdf
Description: Postdoc positions in Dr. Ning Zhao lab.pdf

[ccp4bb] Post-Doc position in Luebeck, Germany

[Thomas Krey]

Dear colleagues,

We invite applications for a

Post-Doc position in Structural Virology / Vaccinology

in the lab of Thomas Krey, Institute of Biochemistry, University of Luebeck 
(Germany). Our group is interested in the study of viruses that constitute a 
global public health and/or veterinary concern and uses mostly structural 
biology/biophysical techniques with a special focus on X-ray crystallography 
and more recently also cryo electron microscopy. The structural knowledge 
gained from our experiments can be used for structure-based design of 
antivirals and/or vaccines, i.e., has a direct translational potential.

Currently, we are looking for a Post-Doc for an exciting collaborative project 
aiming at a PRRSV vaccine.
The position is for three years and further details about it can be found here 
alongside instructions how to apply:

https://biochem.uni-luebeck.de/fileadmin/files/pdf/1023_23_WissMA_Biochemie_E.pdf

Best wishes
Thomas

Prof. Dr. Thomas Krey
[University of Luebeck]
University of Lübeck
Institute of Biochemistry
phone: +49-451-3101-3100
fax: +49-451-3101-3104
e-mail: k...@biochem.uni-luebeck.de
www.biochem.uni-luebeck.de
Ratzeburger Allee 160
23562 Lübeck
Germany





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[ccp4bb] Post-doc position in protein crystallography and drug discovery at the City of Hope

[Jeff Perry]

A post-doctoral position in protein crystallography and drug discovery is 
available in the Perry laboratory at the City of Hope Medical Center in Los 
Angeles, California. The project is focused on hits-to-leads studies against a 
novel diabetes therapeutic target for both type 1 and type 2 forms of the 
disease. This is a collaborative effort between three research groups at the 
City of Hope and is funded by a City of Hope grant for drug development.

The research will involve protein expression, purification, and protein 
crystallography studies to determine co-crystal structures of small 
molecule:protein target complexes, in addition to fragment-based drug discovery 
approaches. Biophysical methods including thermal shift assays and isothermal 
calorimetry will also be employed. 

A PhD in biochemistry or related discipline with a strong background in protein 
crystallography is required. 

Kindly send your cover letter and CV to me at: jpe...@coh.org

informal enquiries are also welcome.
 
Jeff Perry, Ph.D.
Assistant Professor,
MDET, City of Hope Medical Center,
Biomedical Research Center,
1218 S. Fifth Avenue,
Monrovia, CA 91016
cityofhope.org/jeff-perry-lab



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[ccp4bb] Post-doc position - Columbia University, New York

[Liang Tong]

A Post-doctoral Research Associate position is available for structural
studies on proteins involved in RNA processing and quality control, and
other projects, using cryo-EM and crystallography. We have extensive
experience in these areas, and have generated many high-impact publications
(for example Science, 367, 700, 2020; Mol. Cell, 77, 800, 2020). Please
visit our home page for more information-



http://tonglab.biology.columbia.edu/

Strong experience in protein biochemistry is required. Prior experience
with cryo-EM and/or X-ray crystallography is desirable.

Please send CV and names of three references to me by email.



Liang Tong
Department of Biological Sciences
Columbia University
New York, NY 10027
Email: lt...@columbia.edu



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[ccp4bb] Post-doc position in the Perry Lab, City of Hope, Los Angeles, California

[Jeff Perry]

Hi All,

There is a post-doc position open in the Perry laboratory at the City of Hope 
Medical Center in Monrovia (Los Angeles) California. The position is for a 
highly motivated post-doc interested in using structure-based drug discovery 
approaches against a novel protein target.

The application details are at:

https://aa067.taleo.net/careersection/ex/jobdetail.ftl?job=10014174&lang=en

Details on the Perry lab at COH can be found at: 
cityofhope.org/jeff-perry-lab

Best regards,

Jeff





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[ccp4bb] Post-doc position in Monterotondo (Rome, Italy)

[Fulvio Saccoccia]

Dear ccp4i users,

    a ONE-YEAR POST-DOC POSITION is available at the Institue of  
Biochemistry and Cell Biology (IBBC) of National Research Council  
(CNR) settled in Monterotondo (in the nearby of Rome, Italy), in the  
research group of doct. Giovina Ruberti. The project aims at studying  
the histone deacetylase enzymes belonging to /Schistosoma mansoni/, a  
human parasite, with structural biology and enzymology approaches. The  
candidate will be employed as POST-DOC FELLOW AT SAPIENZA UNIVERSITY  
OF ROME, under the supervision of prof. Andrea Bellelli. 


The announcement is online:  
https://web.uniroma1.it/trasparenza/sites/default/files/BANDO%20A_15%20_2021.pdf


Real deadline is 2022, january 17 (first useful working day after  
reported deadline, january 16) 


For further information, please, contact: andrea.belle...@uniroma1.it

More information on the SCHISTODISCOVERY group and its scopes are  
available  
at _http://www.ibbc.cnr.it/research-applications/poverty-diseases/[1]_


Best wishes

Fulvio



Link:
-
[1] http://www.ibbc.cnr.it



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[ccp4bb] Post doc position, AstraZeneca Gothenburg

[Sandmark, Jenny]

Dear all,

We are looking for a Post doc to work on structure-based generation of 
stabilised peptides mimicking proteins involved in cell signalling. The Post 
doc will be based at AstraZeneca Gothenburg, Sweden, working with myself and 
Dr. Anais Noisier and in collaboration with Prof. David Craik at the University 
of Queensland, Australia.


The goal of this postdoctoral project is to generate conformationally stable 
protein-mimetic peptides capable of modulating the formation of multi-protein 
complexes involved in cell signaling.

Protein-Protein Interactions (PPI) are important in the regulation of signaling 
pathways and modulation of PPI is a long-standing challenge in drug discovery. 
One strategy which has shown particular promise is the use of new chemical 
modalities such as protein-mimetic peptides. You will employ structure-based 
design to generate drug-like peptides as potential treatment for diseases 
related to malfunctioning cell signaling. The peptide-protein interactions will 
be characterized using X-ray crystallography and biophysical methods.
The candidate should have a strong background in:

  *   X-ray crystallography
  *   Synthesis, purification and characterization of peptides
  *   Molecular biology and protein purification skills needed to produce high 
quality protein
  *   Proven record of work published in peer-reviewed scientific journals

Preferably all of the above, but strong experience in one and willingness to 
learn new methods will suffice. Since the successful applicant is expected to 
perform most of the experimental work, relevant laboratory experience is 
absolutely required.
Best regards
Jenny


https://careers.astrazeneca.com/job/gothenburg/postdoc-fellow-developing-protein-mimetic-peptides/7684/16564843008




_

Jenny Sandmark
PhD, Associate Principal Scientist

AstraZeneca R&D
Mechanistic and Structural Biology


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Re: [ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
KU Leuven, Belgium (http://www.xtal.be ). The research in 
the Laboratory of Structural Neurobiology is aimed at understanding the 
molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray 
crystallography and cryo-EM in combination with electrophysiological recordings 
and fluorescence-based techniques. Our laboratory hosts an integrated 
macromolecular crystallization facility with a Mosquito crystallization robot 
and two RockImagers. We have access to a 200 kV Glacios microscope on campus as 
well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current 
projects are situated at the crossroads of structural elucidation and drug 
discovery of different pentameric ligand-gated ion channels.

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
crystallography of membrane proteins. The position is open immediately and 
applications will be accepted until the position is filled. Applicants are 
requested to submit a CV with publication list and two references. E-mail to 
chris.ul...@kuleuven.be 


Selection of recent publications:


A lipid site shapes the agonist response of a pentameric ligand-gated ion 
channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch 
J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan 
G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.


Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, 
Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, 
Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.


The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous 
PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, 
Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc 
Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


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Description: S/MIME cryptographic signature

[ccp4bb] post-doc position

[Christine Gee]

Dear all,

The Kuriyan Lab at UC Berkeley is looking for a post-doc interested in
using Next Generation Sequencing and deep mutagenesis to investigate
function and allostery. The job posting can be found here.
https://www.nature.com/naturecareers/job/postdoctoral-associate-kuriyan-lab-howard-hughes-medical-institute-hhmi-744080
If you know a suitable candidate please forward them the information.

Regards
Christine



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[ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
KU Leuven, Belgium (http://www.xtal.be ). The research in 
the Laboratory of Structural Neurobiology is aimed at understanding the 
molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray 
crystallography and cryo-EM in combination with electrophysiological recordings 
and fluorescence-based techniques. Our laboratory hosts an integrated 
macromolecular crystallization facility with a Mosquito crystallization robot 
and two RockImagers. We have access to a 200 kV Glacios microscope on campus as 
well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current 
projects are situated at the crossroads of structural elucidation and drug 
discovery of different pentameric ligand-gated ion channels.

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
crystallography of membrane proteins.

The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit
- has an ambitious work ethic
- critically contributes to writing of manuscripts and grant proposals
- makes efforts to obtain independent funding
- meets intermediate deadlines and brings projects to a successful end
- fuels internal discussions of recent publications in the field
- sets an example to younger PhD students in the lab
- identifies directions for future scientific research


The position is open immediately and applications will be accepted until the 
position is filled. Applicants are requested to submit a CV with publication 
list and two references. E-mail to chris.ul...@kuleuven.be 



Selection of recent publications:


A lipid site shapes the agonist response of a pentameric ligand-gated ion 
channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch 
J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan 
G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.


Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, 
Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, 
Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.


The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous 
PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, 
Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc 
Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


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Description: S/MIME cryptographic signature

[ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
KU Leuven, Belgium (http://www.xtal.be ). The research in 
the Laboratory of Structural Neurobiology is aimed at understanding the 
molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray 
crystallography and cryo-EM in combination with electrophysiological recordings 
and fluorescence-based techniques. Our laboratory hosts an integrated 
macromolecular crystallization facility with a Mosquito crystallization robot 
and two RockImagers. We have access to a 200 kV Glacios microscope on campus as 
well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current 
projects are situated at the crossroads of structural elucidation and drug 
discovery of different pentameric ligand-gated ion channels.

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
crystallography of membrane proteins.

The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit
- has an ambitious work ethic
- critically contributes to writing of manuscripts and grant proposals
- makes efforts to obtain independent funding
- meets intermediate deadlines and brings projects to a successful end
- fuels internal discussions of recent publications in the field
- sets an example to younger PhD students in the lab
- identifies directions for future scientific research


The position is open immediately and applications will be accepted until the 
position is filled. Applicants are requested to submit a CV with publication 
list and two references. E-mail to chris.ul...@kuleuven.be 



Selection of recent publications:


A lipid site shapes the agonist response of a pentameric ligand-gated ion 
channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch 
J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan 
G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.


Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, 
Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, 
Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.


The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous 
PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, 
Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc 
Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


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Re: [ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
KU Leuven, Belgium (http://www.xtal.be). The research in the Laboratory of 
Structural Neurobiology is aimed at understanding the molecular mechanism of 
ligand-gated ion channels. Our methods rely on X-ray crystallography and 
cryo-EM in combination with electrophysiological recordings and 
fluorescence-based techniques. Our laboratory hosts an integrated 
macromolecular crystallization facility with a Mosquito crystallization robot 
and two RockImagers. We have access to a 200 kV Glacios microscope on campus as 
well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current 
projects are situated at the crossroads of structural elucidation and drug 
discovery of different pentameric ligand-gated ion channels.

 We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
crystallography of membrane proteins.
 
The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit
- has an ambitious work ethic
- critically contributes to writing of manuscripts and grant proposals
- makes efforts to obtain independent funding
- meets intermediate deadlines and brings projects to a successful end
- fuels internal discussions of recent publications in the field
- sets an example to younger PhD students in the lab
- identifies directions for future scientific research

 
The position is open immediately and applications will be accepted until the 
position is filled. Applicants are requested to submit a CV with publication 
list and two references. E-mail to chris.ul...@kuleuven.be

 
Selection of recent publications:

 
A lipid site shapes the agonist response of a pentameric ligand-gated ion 
channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch 
J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan 
G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.

 
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, 
Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, 
Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.

 
The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous 
PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, 
Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc 
Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


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Re: [ccp4bb] Post Doc position at ESRF ID29

[Vatsal Purohit]

My apologies – didn’t mean to send this to the whole list.

-Vatsal


PhD Candidate, Stauffacher Lab, Dept. of Biology, Purdue University

PULSe-Biophysics and Structural Biology training group

vpur...@purdue.edu<mailto:praka...@purdue.edu> | 346-719-9409

From: Vatsal Purohit<mailto:vpur...@purdue.edu>
Sent: 02 April 2021 19:55
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: Re: [ccp4bb] Post Doc position at ESRF ID29

Hi Dr. Sanctis,

I am interested in applying for this position and wanted to ask you if it would 
be possible for me to attach the contact information of the references in my 
application instead of attaching the letters themselves. It would be to their 
preference to be contacted and share their letters of recommendation directly. 
It would be really helpful if you could let me know!

Regards,
Vatsal


PhD Candidate, Stauffacher Lab, Dept. of Biology, Purdue University

PULSe-Biophysics and Structural Biology training group

vpur...@purdue.edu<mailto:praka...@purdue.edu> | 346-719-9409

From: Daniele de Sanctis<mailto:de.sanct...@gmail.com>
Sent: 30 March 2021 03:13
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp4bb] Post Doc position at ESRF ID29

Hi all,

still time to apply for the Post Doc position to join the ID29 upgrade project 
at the ESRF to develop novel sample delivery systems and tools for time 
resolved serial crystallography experiments.

The new ID29 is currently being upgraded in a new serial time-resolved 
crystallography beamline that can fully profit from the ESRF Extremely 
Brilliant Source. The beamline will deliver >10^15 ph/s in a submicron beam 
size with a wide band pass monochromator and allow for exposure time of a few 
microseconds. It is equipped with the latest generation MD3upSSX and a Jungfrau 
detector (more information are presented here 
https://www.youtube.com/watch?app=desktop&v=B1fB9xvouLE).

Applications should be submitted to the ESRF portal 
https://esrf.gestmax.eu/1500/1/postdoc-id29/en_US?backlink=search

Best regards

Daniele


ἀρετή
---
Daniele de Sanctis
Structural Biology Group
ESRF - The European Synchrotron
Grenoble, France
Tel 33 (0)4 76 88 2869

http://www.esrf.eu/id29



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Re: [ccp4bb] Post Doc position at ESRF ID29

[Vatsal Purohit]

Hi Dr. Sanctis,

I am interested in applying for this position and wanted to ask you if it would 
be possible for me to attach the contact information of the references in my 
application instead of attaching the letters themselves. It would be to their 
preference to be contacted and share their letters of recommendation directly. 
It would be really helpful if you could let me know!

Regards,
Vatsal


PhD Candidate, Stauffacher Lab, Dept. of Biology, Purdue University

PULSe-Biophysics and Structural Biology training group

vpur...@purdue.edu<mailto:praka...@purdue.edu> | 346-719-9409

From: Daniele de Sanctis<mailto:de.sanct...@gmail.com>
Sent: 30 March 2021 03:13
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp4bb] Post Doc position at ESRF ID29

Hi all,

still time to apply for the Post Doc position to join the ID29 upgrade project 
at the ESRF to develop novel sample delivery systems and tools for time 
resolved serial crystallography experiments.

The new ID29 is currently being upgraded in a new serial time-resolved 
crystallography beamline that can fully profit from the ESRF Extremely 
Brilliant Source. The beamline will deliver >10^15 ph/s in a submicron beam 
size with a wide band pass monochromator and allow for exposure time of a few 
microseconds. It is equipped with the latest generation MD3upSSX and a Jungfrau 
detector (more information are presented here 
https://www.youtube.com/watch?app=desktop&v=B1fB9xvouLE).

Applications should be submitted to the ESRF portal 
https://esrf.gestmax.eu/1500/1/postdoc-id29/en_US?backlink=search

Best regards

Daniele


ἀρετή
---
Daniele de Sanctis
Structural Biology Group
ESRF - The European Synchrotron
Grenoble, France
Tel 33 (0)4 76 88 2869

http://www.esrf.eu/id29



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1




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[ccp4bb] Post Doc position at ESRF ID29

[Daniele de Sanctis]

Hi all,

still time to apply for the Post Doc position to join the ID29 upgrade
project at the ESRF to develop novel sample delivery systems and tools for
time resolved serial crystallography experiments.

The new ID29 is currently being upgraded in a new serial time-resolved
crystallography beamline that can fully profit from the ESRF Extremely
Brilliant Source. The beamline will deliver >10^15 ph/s in a submicron beam
size with a wide band pass monochromator and allow for exposure time of a
few microseconds. It is equipped with the latest generation MD3upSSX and a
Jungfrau detector (more information are presented here
https://www.youtube.com/watch?app=desktop&v=B1fB9xvouLE).

Applications should be submitted to the ESRF portal
https://esrf.gestmax.eu/1500/1/postdoc-id29/en_US?backlink=search

Best regards


Daniele


ἀρετή
---
Daniele de Sanctis
Structural Biology Group
ESRF - The European Synchrotron
Grenoble, France
Tel 33 (0)4 76 88 2869

http://www.esrf.eu/id29



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1

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hosted by www.jiscmail.ac.uk, terms & conditions are available at 
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[ccp4bb] Post Doc position at ESRF ID29

[Daniele de Sanctis]

Dear all,

We have a new opening for a Post Doc position to join the ID29 upgrade
project at the ESRF.

ID29 is currently being upgraded in a new serial crystallography beamline
that can fully profit from the ESRF Extremely Brilliant Source. We are
looking for someone with strong motivation in developing methods and tools
for room temperature time resolved serial crystallography to be deployed on
the new ID29.

Feel free to contact me for further information. For more information and
to apply see

https://esrf.gestmax.eu/1500/1/postdoc-id29/en_US?backlink=search

The closing date is Tuesday 6th April.

Best regards

Daniele

ἀρετή
---
Daniele de Sanctis
Structural Biology Group
ESRF - The European Synchrotron
Grenoble, France
Tel 33 (0)4 76 88 2869

http://www.esrf.eu/id29



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Re: [ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

This is a reminder for interested candidates to apply for the vacant position 
below.

Thank you and best regards
Chris


> On 5 Jan 2021, at 17:33, Chris Ulens  wrote:
> 
> A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
> KU Leuven, Belgium (http://www.xtal.be ). The research 
> in the Laboratory of Structural Neurobiology is aimed at understanding the 
> molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray 
> crystallography and cryo-EM in combination with electrophysiological 
> recordings and fluorescence-based techniques. Our laboratory hosts an 
> integrated macromolecular crystallization facility with a Mosquito 
> crystallization robot and two RockImagers. We have access to a 200 kV Glacios 
> microscope on campus as well as 300 kV JEOL CryoARM300 at the nearby EM 
> facility in Brussels. Current projects are situated at the crossroads of 
> structural elucidation and drug discovery of different pentameric 
> ligand-gated ion channels.
> 
>  
> We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
> crystallography of membrane proteins.
> 
>  
> The successful candidate:
> 
> - easily communicates in an open verbal manner and has a team player spirit
> 
> - has an ambitious work ethic
> 
> - critically contributes to writing of manuscripts and grant proposals
> 
> - makes efforts to obtain independent funding
> 
> - meets intermediate deadlines and brings projects to a successful end
> 
> - fuels internal discussions of recent publications in the field
> 
> - sets an example to younger PhD students in the lab
> 
> - identifies directions for future scientific research
> 
>  
> The position is open immediately and applications will be accepted until the 
> position is filled. Applicants are requested to submit a CV with publication 
> list and two references. E-mail to chris.ul...@kuleuven.be 
> 
>  
> Selection of recent publications:
> 
>  
> A lipid site shapes the agonist response of a pentameric ligand-gated ion 
> channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, 
> Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, 
> Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
> 2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.
> 
>  
> Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
> receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price 
> KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs 
> RE, Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.
> 
>  
> The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
> of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, 
> Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, 
> Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, 
> Oberwinkler J. Proc Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 
> 10.1073/pnas.2001177117.
> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 
> 



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Description: S/MIME cryptographic signature

[ccp4bb] Post-doc position - Columbia University

[Liang Tong]

A Post-doctoral Research Associate position is available for structural
studies on proteins involved in RNA processing and quality control, using
cryo-EM and crystallography. We have extensive experience in these areas,
and have generated many high-impact publications (for example Science, 367,
700, 2020; Mol. Cell, 77, 800, 2020). Please see our home page for more
information-



http://tonglab.biology.columbia.edu/


Strong experience in protein biochemistry is required. Prior experience
with cryo-EM and/or X-ray crystallography is desirable.


Please send CV and names of three references to me by email.


Liang Tong

Department of Biological Sciences
Columbia University
New York, NY 10027
Email: lt...@columbia.edu



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[ccp4bb] post-doc position at KU Leuven, ligand-gated ion channels

[Chris Ulens]

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, 
KU Leuven, Belgium (http://www.xtal.be ). The research in 
the Laboratory of Structural Neurobiology is aimed at understanding the 
molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray 
crystallography and cryo-EM in combination with electrophysiological recordings 
and fluorescence-based techniques. Our laboratory hosts an integrated 
macromolecular crystallization facility with a Mosquito crystallization robot 
and two RockImagers. We have access to a 200 kV Glacios microscope on campus as 
well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current 
projects are situated at the crossroads of structural elucidation and drug 
discovery of different pentameric ligand-gated ion channels.

 

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray 
crystallography of membrane proteins.

 

The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit

- has an ambitious work ethic

- critically contributes to writing of manuscripts and grant proposals

- makes efforts to obtain independent funding

- meets intermediate deadlines and brings projects to a successful end

- fuels internal discussions of recent publications in the field

- sets an example to younger PhD students in the lab

- identifies directions for future scientific research

 

The position is open immediately and applications will be accepted until the 
position is filled. Applicants are requested to submit a CV with publication 
list and two references. E-mail to chris.ul...@kuleuven.be 

 

Selection of recent publications:

 

A lipid site shapes the agonist response of a pentameric ligand-gated ion 
channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch 
J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan 
G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 
2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.

 

Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 
receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, 
Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, 
Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.

 

The structural basis for an on-off switch controlling Gβγ-mediated inhibition 
of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous 
PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, 
Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc 
Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


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[ccp4bb] Post-doc Position - Structural approaches to novel fragment based and natural product antibiotic discovery

[Bertram, Felicity (DLSLtd,RAL,LSCI)]

Applications are invited for a highly motivated and experienced postdoctoral 
researcher to join an active research group at the School of Life Sciences, 
University of Warwick supervised by a team headed by Prof Chris Dowson with 
Prof Frank von Delft at Oxford University and Diamond Light Source. The 
project, which has been recently supported by the Newton Fund, focuses on 
acquiring specific structural and biochemical data using a novel strategy of HT 
affinity crystallography, using robust crystals of well validated and novel 
antibacterial targets to identify either fragment-based inhibitors or 
inhibitors identified by crystallography directly from complex mixtures of 
natural products. This position is available for up to 18 months in the first 
instance and will involve substantive interactions with academic colleagues at 
Harwell and those in China.

More information about the post can be found below, and you can contact Prof 
Chris Dowson at c.g.dow...@warwick.ac.uk:
https://atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTg3MzA0OCZ2dF90ZW1wbGF0ZT0xNDU3Jm93bmVyPTUwNjI0NTImb3duZXJ0eXBlPWZhaXImYnJhbmRfaWQ9MCZ2YWNfeHRyYTUwNjI0NTIuODFfNTA2MjQ1Mj0yMzk4OTUmcG9zdGluZ19jb2RlPTYzNQ==

Best regards,
Felicity.

Felicity Bertram
felicity.bert...@diamond.ac.uk
MX Support Scientist

Diamond Light Source, Harwell Science & Innovation Campus, Didcot, Oxfordshire, 
OX11 0DE
+44 1235 778387
Skype: felicity.bertram.uk
[START-Logo-final] [Athena-Swan-Bronze-Award] [Diability Confident 
Logo]


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[ccp4bb] Post Doc position : cryoEM

[Natesh Ramanathan]

Dear All,

  A postdoc position is available in my group at the School of Biology
(SoB), IISER Thiruvananthapuram (IISER-TVM), Kerala, INDIA. Our campus is
arguably one of the most picturesque in India (http://www.iisertvm
.ac.in/pages/campus), and is close to the excellent tropical mountain (e.g
Ponmudi).

  We are looking for a highly motivated, talented and self-driven
postdoctoral researcher to carry structural studies of the protein-protein,
protein-DNA and protein-drug complexes in order to understand the
structure, function and molecular mechanism of transcription
regulators in *Mycobacterium
spp*.  The postdoctoral position is funded by Institute Fellowship.  You
will be working on a project funded by MHRD (Ministry of Human Resource and
Development, Government of India).  More information about our research and
training can be found at our lab page here
http://faculty.iisertvm.ac.in/natesh/.

 You will be part of a friendly and supportive team working on
challenging projects using single-particle cryoEM and Protein
Crystallography(PX) and will benefit from additional interactions with the
wider scientific community and excellent scientific facilities and training
opportunities at IISER-TVM.

You should have a PhD (preferably fresh PhD candidate) or with
maximum 1 or 2 years of postdoctoral experience with a strong background in
protein biochemistry, molecular biology, structural biology or related
field. Applicants with experience in protein expression purification,
single-particle cryoEM and/or Protein crystallography is highly desirable.
Expertise with insect cell line expression system/cryo cellular tomography
will be an added advantage, but not necessary. If the candidate
has expertise in PX and is interested in getting trained in cryoEM you
are encouraged to apply.  The candidate should have excellent communication
skills, and be comfortable working collaboratively with other lab members.

 The individual will receive a competitive salary with On-campus
housing and work in an excellent environment.

Deadline for applications is 9th of June 2020.

For informal enquires please contact Dr Ramanathan Natesh at the email ID
nat...@iisertvm.ac.in.

JOB details:

Postdoctoral position fixed term 3 years (1 year + 2 years.  Based on
performance after 1 year, the position can be extended to 2 more years ).

Age limit is 32 years at the time of application.

Institute Fellowship amount: INR 55,000. pm  (On-campus housing will be
provided).

Qualified applicants should submit a CV along with a list of publications
and research interests, a cover letter summarizing research experience, a
research proposal (Max. 3 to 4 pages) and the names of three references to
Dr. Ramanathan Natesh (nat...@iisertvm.ac.in).  Applications will be
reviewed upon receipt. The start date for the position is tentatively
August 2020 or as early as possible.

Best regards,
Natesh
--
"Live Simply and do Serious Things .. "
- Dorothy Mary Crowfoot Hodgkin OM, FRS

"In Science truth always wins"
- Max Ferdinand Perutz OM FRS
--
Dr. Ramanathan Natesh
Assistant Professor,
School of Biology,
Indian Institute of Science Education and Research Thiruvananthapuram
(IISER-TVM),
Maruthamala P.O., Vithura,
Thiruvananthapuram,  695551, Kerala, India

nat...@iisertvm.ac.in
http://www.researcherid.com/rid/C-4488-2008
ORCID: http://orcid.org/-0002-1145-5962
https://publons.com/author/1520837/ramanathan-natesh#profile
http://faculty.iisertvm.ac.in/natesh

Office Ph. 0091- 471-2778087



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[ccp4bb] Post doc position in Oulu

[Peppi Karppinen]

Dear all,


There is an opening for a post doc with experience in recombinant protein 
production and purification, enzyme kinetic analyses and structural biology 
(crystallization, cryoEM) in our group in University of Oulu, Finland. Our 
research focuses on the enzyme family of 2-oxoglutarate-dependent dioxygenases 
and their potential as therapeutic targets. Our main interests are in the 
hypoxia-inducible factor prolyl 4-hydroxylases, P4H-TM and histone 
demethylases. We offer a research environment with excellent technological 
facilities and a motivating and supporting community. Deadline Feb 21.



More information: 
https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=8708&lang=fi



Recent publications:

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, 
Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock 
BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. 
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell 
fate. Science. 2019 Mar 15;363(6432):1217-1222.



Laukka T, Myllykoski M, Looper RE, Koivunen P. Cancer-associated 2-oxoglutarate 
analogues modify histone methylation by inhibiting histone lysine demethylases. 
J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092.



Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp 
AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, 
Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, 
Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J. 
Biallelic loss-of-function P4HTM gene variants cause hypotonia, 
hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye 
abnormalities (HIDEA syndrome). Genet Med. 2019 Oct;21(10):2355-2363.


Peppi Karppinen (Koivunen), MD, PhD
Professor, Dean
University of Oulu
Faculty of Biochemistry and Molecular Medicine
Room L203 │ Aapistie 7A │FIN-90014 University of Oulu
FINLAND
_
Email   peppi.karppi...@oulu.fi
Phone  +358 (0) 294 485822
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Peppi Karppinen (Koivunen), MD, PhD
Professor, Dean
University of Oulu
Faculty of Biochemistry and Molecular Medicine
Room L203 │ Aapistie 7A │FIN-90014 University of Oulu
FINLAND
_
Email   peppi.karppi...@oulu.fi
Phone  +358 (0) 294 485822
[cid:image002.jpg@01D5E710.F376A670]
Follow us on Facebook, 
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Twitter.
The content of this message is confidential. If you are not a recipient 
indicated or intended in this message or you think this message may have been 
addressed to you in error, please inform us by an email reply and then delete 
the message. In such case it is forbidden to copy, forward, or in any way 
reveal the contents of this message to anyone.





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[ccp4bb] Post doc position available at Florida State University

[Adarsh Kumar]

Dear all

One postdoctoral position is available immediately in an enzymology laboratory 
to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base 
excision repair catalyzed by various human and viral DNA/RNA polymerases, and 
to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and 
Cas13a. Background in structural biology (X-ray crystallography and/or CryoEM), 
biophysics, protein purification, and recombinant DNA techniques is preferred. 
An important criterion for selection will be the ability of the desired 
individual to pursue independent research in an active multi-disciplinary 
setting. Interested candidates should send a CV and a statement describing 
experience, goals, and reasons for the interest in this position, and arrange 
to have three letters of recommendation sent to Dr. Zucai Suo, Eminent 
Professor and Dorian and John Blackmon Chair of Biomedical Science, Department 
of Biomedical Sciences, College of Medicine, Florida State University, 
Tallahassee, FL. Dr. Suo can be contacted by email (zucai@med.fsu.edu). 
Further information about the research projects in the Suo Lab can be obtained 
from https://med.fsu.edu/index.cfm?page=suolab.research.

Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Salary: NIH guidelines for post-doctoral salaries + benefits
Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural 
Biology, and Biomedical Sciences
Position Type: Full Time
Organization Type: Academia
Job Type: Postdoc



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[ccp4bb] Post-doc position in algorithm development in the Molecular Biophysics and Integrated Bioimaging division at LBL.

[Kanupriya Pande]

Post-doc position in algorithm development in the Molecular Biophysics and
Integrated Bioimaging division at Lawrence Berkeley National Lab.

The overall objectives of the project are to develop theory and computation
to extract conformational heterogeneity and disorder from diffraction and
imaging data. The position is available immediately with an initial
appointment for 2 years with the possibility of renewal based upon
satisfactory job performance, continuing availability of funds and ongoing
operational needs.

Qualified candidates must have a PhD in Biophysics, Physics, Mathematics,
Chemistry, or related fields. Interested candidates are encouraged to apply
using the following link:
https://lbl.referrals.selectminds.com/jobs/computational-biologist-postdoc-fellow-2095

For further questions please feel free to contact me via email (kpande[at]
lbl.gov).

Thanks,
Kanupriya.



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[ccp4bb] Post doc position at Imperial College London

[Ali, Maruf]

Dear all,



There is a post-doctoral position available in the lab of Dr Maruf Ali at 
Imperial College, London.



The research project focuses on determining the structure and mechanism of ER 
chaperone complexes involved in stress signaling/unfolded protein response and 
protein homeostasis.  Methodology will include cryo-electron microscopy (EM) 
and a suite of biophysical, biochemical and cellular assays to determine 
structure and function.



Please see 
https://www.imperial.ac.uk/jobs/description/NAT00509/research-associate/ for 
further information or contact me informally maruf@imperial.ac.uk



closing date for applications is: 18th Sept 2019

all the best,

Maruf


-
Dr Maruf Ali
Senior Cancer Research UK Fellow
RM 505 Sir Ernst Chain Building
Department of Life Sciences
Imperial College
London SW7 2AZ
Tel: 0207 594 5733
-



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[ccp4bb] Post-doc position in structural biology/drug discovery/design

[Jon R Sayers]

We wish to appoint a talented and ambitious Research Associate to develop
novel approaches to targeting malaria and tuberculosis. Drug resistance is
becoming increasingly problematic in malaria and TB, two of the most-deadly
diseases in human history. The WHO estimates that there were over half a
million cases of drug-resistant TB in 2017. This exciting pilot project is
funded by the Bill&Melinda Gates Foundation for 13 months to investigate
the feasibility of developing inhibitors of DNA replication in these
globally important pathogens.

You will have a Ph.D. (or be close to completion) in a relevant
life-sciences subject and experience in X-ray crystallography, structure
refinement, protein purification and executing crystallization trials. The
successful applicant will conduct world-class research in structure-based
drug design to develop inhibitors of microbial flap endonucleases (FENs).
FEN enzymes are involved in cellular DNA synthesis and genome damage
repair. We have shown that a member of this important class of enzymes
contains a novel DNA-binding motif, the helical arch (Al Malki et al, Direct
observation of DNA threading in flap endonuclease complexes. 2016, Nature
Structural and Molecular Biology, 23, 640-646).

You will facilitate production, crystallization and X-ray crystal structure
determination of FEN enzymes and their complexes with inhibitors. You will
work closely with a second postdoctoral Research Associate carrying out
enzyme production and inhibitor assays as well as with chemo- informatics
experts. We welcome highly dedicated and enthusiastic candidates with the
ability to develop their scientific skills in the direction of rational
drug design.

You will join a multi-disciplinary team spanning two research groups: The
Sayers lab is based within the Dept. of Infection, Immunity and
Cardiovascular Disease; and the Baker group is housed within the Dept. of
Molecular Biology and Biotechnology. This vibrant team works on FEN
mechanism and applications in biotechnology as well as inhibitor discovery
in other target organisms. We use site- directed mutagenesis,
crystallography and kinetic approaches to determine how these complicated
enzymes function in order to design inhibitors in conjunction with virtual
and physical screening. The groups are housed within well-equipped
laboratories with access to excellent core facilities with state-of-the-art
equipment for e.g. biological mass spectrometry, nucleic acid sequencing,
X-ray crystallography, liquid handling for high throughput screening,
crystallization robotics, plus a range of microscopy facilities, etc. The
Sayers group hosts a Marie Curie Individual Fellow and PhD students working
on homologous FENs derived from bacteria and viruses. For more details of
our FEN research see: www.sayers.staff.shef.ac.uk/fen/index.html


-- 
Professor Jon R Sayers, FRSB
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield Medical School
Beech Hill Rd
Sheffield
S10 2RX
United Kingdom

Tel: +44 (0)114 215 9552
Fax: +44 (0)114 271 1863
Email: j.r.say...@sheffield.ac.uk

http://www.sheffield.ac.uk/iicd/profiles/sayers



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[ccp4bb] Post-doc position

[Phoebe A. Rice]

A post-doctoral position is open in the Rice lab at the University of Chicago 
(https://voices.uchicago.edu/phoebericelab/).  The primary project is to figure 
out, through biochemistry and structural biology, the mechanisms of 
self-loading helicases encoded by medically nasty staphylococcal mobile genetic 
elements.  The lab employs a variety of approaches from cryo-EM and 
crystallography through biochemistry and microbiology, all aimed at 
understanding mobile DNA elements at the molecular level.  A variety of 
additional project opportunities are also available.
The Advanced Electron Microscopy Facility at the University of Chicago 
currently houses a 200 KV Talos F200C microscope with side-entry holders and a 
Vitrobot plunge freezer for cryo screening, a 120 KV Spirit microscope for 
negative-staining, and a 300 KV Tecnai F30 for plastic tomography.
The University has made > 10M dollars in investments to upgrade the facility 
with a state-of-the-art 300 KV Titan Krios microscope equipped with a K3 direct 
detection camera and Volta phase plate, which will be fully installed by the 
end of 2019. Additional upgrades include a Aquilos cryo FIB-SEM Leica, Apreo 
volume scope and Leica EM GP2 cryo-plunge.
The Advanced Photon Source’s fantastic x-ray beamlines are also a short drive 
away.
Top candidates will have a PhD (or be about to receive one) and experience in 
cryo-EM and biochemistry.  To apply, please send your CV, with names and 
contact information for 3 references, to me by e-mail: 
pr...@uchicago.edu

Be the one who turns this science fiction figure into reality!
[cid:image001.png@01D5281E.B2A586E0]
The University of Chicago is an Affirmative Action/Equal 
Opportunity/Disabled/Veterans Employer and does not discriminate on the basis 
of race, color, religion, sex, sexual orientation, gender identity, national or 
ethnic origin, age, status as an individual with a disability, protected 
veteran status, genetic information, or other protected classes under the law. 
For additional information please see the University's Notice of 
Nondiscrimination at 
http://www.uchicago.edu/about/non_discrimination_statement/. Job seekers in 
need of a reasonable accommodation to complete the application process should 
call 773-702-0287 or email 
acoppadministra...@uchicago.edu with 
their request.

~~~
Phoebe A. Rice
Dept. of Biochem & Mol. Biol. and
  Committee on Microbiology
https://voices.uchicago.edu/phoebericelab/




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Re: [ccp4bb] Post Doc position available in Denmark

[Bjørn Panyella Pedersen]

Just a brief reminder of the following open position. Deadline is in ten days. 

All the best,
-Bjørn


From: CCP4 bulletin board  on behalf of Bjørn Panyella 
Pedersen 
Sent: Monday, August 13, 2018 13:31
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Post Doc position available in Denmark

Postdoctoral position in Structure of Sterol Transporting Membrane
Proteins at Aarhus University, Denmark.

online posting:
http://www.pedersenlab.dk/source/bp_lab_postdoc_position.pdf


The Pedersen group is looking for a highly skilled and motivated postdoc
with an interest in working on sterol and hormone transporting membrane
transporters and with a proven track record in the area of structural
and/or functional analysis of membrane proteins.

The position will be open from fall 2018, and starting date is
negotiable. Funding is available for at least 2 years of employment,
with an automatic extension possible for up to a total maximum of 4 years.

The position:
The position seeks to strengthen ongoing activities in the laboratory of
Bjørn P. Pedersen on structure, related to the function and mechanism of
sterol-transporting membrane proteins (pedersenlab.dk). The laboratory's
interest is the interplay between structure and function of
transmembrane transport processes with a focus on metabolite uptake
systems, and the methods uses are primarily crystallography, cryo-EM and
biochemistry. The group is part of the Section of Structural Biology at
Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and
documented background in structural biology, biochemistry and/or
biophysics. Experience with membrane protein expression and purification
is favored, and the candidate must demonstrate an ability and interest
to work with membrane proteins with a structural aim. Finally,
applicants should be ambitious, show strong collaborative skills, and
should also be able to take initiatives and responsibility within the
work environment.

Deadline:
All applications must be made online and received by 16/09/2018.




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[ccp4bb] Post Doc position available in Denmark

[Bjørn Panyella Pedersen]

Postdoctoral position in Structure of Sterol Transporting Membrane 
Proteins at Aarhus University, Denmark.

online posting:
http://www.pedersenlab.dk/source/bp_lab_postdoc_position.pdf


The Pedersen group is looking for a highly skilled and motivated postdoc 
with an interest in working on sterol and hormone transporting membrane 
transporters and with a proven track record in the area of structural 
and/or functional analysis of membrane proteins.

The position will be open from fall 2018, and starting date is 
negotiable. Funding is available for at least 2 years of employment, 
with an automatic extension possible for up to a total maximum of 4 years.

The position:
The position seeks to strengthen ongoing activities in the laboratory of 
Bjørn P. Pedersen on structure, related to the function and mechanism of 
sterol-transporting membrane proteins (pedersenlab.dk). The laboratory's 
interest is the interplay between structure and function of 
transmembrane transport processes with a focus on metabolite uptake 
systems, and the methods uses are primarily crystallography, cryo-EM and 
biochemistry. The group is part of the Section of Structural Biology at 
Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and 
documented background in structural biology, biochemistry and/or 
biophysics. Experience with membrane protein expression and purification 
is favored, and the candidate must demonstrate an ability and interest 
to work with membrane proteins with a structural aim. Finally, 
applicants should be ambitious, show strong collaborative skills, and 
should also be able to take initiatives and responsibility within the 
work environment.

Deadline:
All applications must be made online and received by 16/09/2018.



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[ccp4bb] Post Doc position available

[Przemyslaw Grudnik]

We have a job opening for a highly-motivated postdoctoral fellow who holds  
a Ph.D. degree for no longer than five years.
The successful candidate will be involved in projects carried out in the  
newly established Structural Biology Core Facility at Jagiellonian  
University in Krakow, Poland.


Job offer website:  
https://www.fnp.org.pl/assets/Job-offer-1_FIRST-TEAM_S-Glatt.pdf

Laboratory website: http://www.mcb.uj.edu.pl/en/mpl

The ideal candidate should:
- hold a doctoral degree for no longer than 5 years
- have a strong expertise in structural biology (Macromolecular  
Crystallography) and biochemistry
- Have excellent written and oral communication skills in English  
(essential)
- Have good presentation skills (ideally having presented on at least one  
international research conference)

- Enjoy working in a highly collaborative and interdisciplinary environment
- Enjoy scientifically supporting and actively interacting with other  
members of the lab
- Have published at least one publications as first author in an  
international peer reviewed journal


We offer:

- Position for three years with possible extension after the project ends
- Excellent training: In our diverse group you will be able to network  
with international researchers, experience and learn new skills in  
cellular & molecular biology.
- State-of the-art research center with access to the full suite of  
equipment necessary for cell biology, molecular biology,
biochemistry and structural biology research and a network of  
international collaborators in Europe and beyond.


Interested applicants should send a cover letter and CV with the names of  
two references to Sebastian Glatt sebastian.gl...@uj.edu.pl




--
Przemyslaw Grudnik Ph.D.
Structural Biology Core Facility
Malopolska Centre of Biotechnology (MCB)
Jagiellonian University

ul. Gronostajowa 7a 30-387 Krakow, Poland
+48 12 664-61-06



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[ccp4bb] Post-doc position available at University of Texas Medical Branch (UTMB)

[Choi, Kyung]

Post-doc position at University of Texas Medical Branch (UTMB), TX, USA

Postdoctoral positions in structural biology are available in Dr. Kay Choi's 
laboratory at the University of Texas Medical Branch (UTMB) to participate in 
virus replication projects. We use a combination of X-ray crystallography, 
cryo-electron microscopy (cryo-EM), and biochemistry to investigate the 
structure and mechanism of viral macromolecular complexes. Experience in either 
X-ray crystallography, cryo-EM or biochemistry is required.  For more 
information please see ‘https://bmb.utmb.edu/faculty/choi.asp’

The X-ray crystallography resources at UTMB include two X-ray area detector 
systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and 
an Alchemist liquid handling robot. The cryo-EM includes two JOEL 200 keV 
cryo-EM microscopes for high-resolution imaging work, an FEI vitrobot, and a 
BSL-3 room for viral and pathogen work.  For more information, please see 
‘https://scsb.utmb.edu/resources/default.asp’

Interested parties should send a cover letter, CV and a list of 2-3 references 
to Dr. Kay Choi via e-mail at kyc...@utmb.edu.

Kay

Kay Choi
Associate Professor
Department of Biochemistry and Molecular Biology
6.614C Basic Science phone 
: 409-747-1402
The University of Texas Medical Branch fax : 
409-747-1404
301 University Blvd.  
email : kay.c...@utmb.edu
Galveston, TX 77555-0647

[ccp4bb] Post-doc position at University of California, San Francisco

[John Gross]

Postdoctoral Position: Structural Biology of Host-Pathogen Conflict

 

There is a post-doctoral position available in the laboratory of John Gross at 
UCSF. The basic science question is how structural adaptation in viral 
suppressors of innate immunity allowed cross-species transmission and the 
origin of modern pandemics such as AIDS. The position is NIH funded for several 
years. Candidates will have expertise in X-ray crystallography and quantitative 
biochemistry of macromolecular complexes.  Experience with eukaryotic protein 
expression systems is desirable.

 

The Gross lab is part of the HARC center (https://harc.ucsf.edu/ 
) and the Macromolecular Structure Group 
(http://www.msg.ucsf.edu/ ) at UCSF.  This strong 
collaborative environment will allow the applicant to integrate structural and 
biochemical studies with evolutionary analysis and molecular virology.

 

 

Applications materials, including CV and contact information for three 
references should be sent to:

 

jdgr...@cgl.ucsf.edu  

 

 

with “post-doc position” written in subject line.

 

—
John Gross
Professor
Department of Pharmaceutical Chemistry
California Institute for Quantitative Biosciences

UCSF, Mission Bay, Genentech Hall
600 16th Street
S-512E, Box 2280
San Francisco, CA 94143-2280
UPS/FedEx/DHL use zip code 94107
Phone: (415) 514-4402
Fax:  (415) 502-8298
Email:  jdgr...@cgl.ucsf.edu

Assistant: Lili Li 
lili...@ucsf.edu



smime.p7s
Description: S/MIME cryptographic signature

[ccp4bb] Post-doc position at AstraZeneca

[Käck , Helena]

Dear all,

We have an opening for a Post-Doc Fellow in CryoEM/Structural biology at 
AstraZeneca in Gothenburg. The aim of the project is to study multi-protein 
complexes of relevance for cellular signaling. The project will be a 
collaboration with Dr. Alexey Amunts at SciLifeLab, Stockholm University.

For more information about the position and how to apply, follow this link:
https://job-search.astrazeneca.com/job/gothenburg/post-doc-fellow-cryoem-structural-biology-of-protein-complexes/7684/7417154

Kind regards,

Helena Käck


Dr Helena Käck
Associate Principal Scientist, Structure & Biophysics
__

AstraZeneca
R&D | Innovative Medicines | Discovery Sciences
Pepparedsleden 1, SE-432 83 Molndal Sweden R&D
helena.k...@astrazeneca.com
Tel +46 31 7064060

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[ccp4bb] Post-doc Position in time-resolved BioSAXS at the Max IV Laboratory

[Marjolein Thunnissen]

Hi

On behalf of my colleague Tómas Plivilic I would like to draw attention to a 
postdoctoral position within time_resolved BioSAXS opening at MAX IV in Lund, 
Sweden..


The CoSAXS beamline is a state-of-the-art multipurpose Small Angle X-ray 
Scattering (SAXS) instrument at MAX IV which is currently under construction 
(https://www.maxiv.lu.se/accelerators-beamlines/beamlines/cosaxs/). It will 
offer high brilliance, monochromatic and tunable X-rays, with outstanding 
performance in low beam divergence, high X-ray flux, and variable beam sizes in 
the full range of the sample-detector distances provided by the beamline (up to 
18 m).

The beamline will be equipped with state of the art SAXS/WAXS detectors. 
Several techniques will be available through modular operation: time resolved 
SAXS, SAXS/WAXS, protein solution SAXS (BioSAXS), micro-focusing SAXS and XPCS. 
It is due to commence full user operation in 2019.

We are offering a postdoctoral position to develop the capabilities of the 
beamline to perform time resolved BioSAXS measurements at seconds to 
milliseconds time scales. The postdoc should be prepared to integrate a flowing 
sample environment with rapid data collection strategies whilst, for example, 
inducing temperature jumps by either laser or terahertz radiation heating. 
Specific data interpretation strategies should be introduced.

The candidate will also be able to develop their own research projects 
exploring further possibilities for time resolved SAXS in a broader range of 
applications. Support will be provided including development beamtime and the 
possibility to apply for beamtime in other large scale facilities. The 
technical developments will be made available to the CoSAXS user community of 
MAX IV Laboratory. This position is funded through a Röntgen-Ångström-Cluster 
funded project “Non-equilibrium thermodynamics of biology studied by 
time-resolved small-angle X-ray and neutron scattering” (http://ttsas.eu).

For more information on this position see  
https://lu.varbi.com/en/what:job/jobID:184632/iframeEmbedded:0/where:4
To contact at Max IV: ann.te...@maxiv.lu.se or 
tomas.plivi...@maxiv.lu.se

Best regards

Marjolein Thunnissen
[cid:3A2194AC-734C-45EB-B5A7-CE7FC0F0F1BC]






Dr. Marjolein Thunnissen
Head User Office

MAX IV Laboratory
Lund University
P.O. Box 118, SE-221 00 Lund, Sweden
Visiting address: Fotongatan 2, 225 94 Lund
Telephone:+46 46 2224668
Mobile:  +46 766 32 04 17
www.maxliv.lu.se

[ccp4bb] post-doc position at SLAC/Stanford University

[van den Bedem, Henry]

Post-doctoral position in the Biosciences Division
at SLAC National Accelerator Laboratory/Stanford University

The Biosciences Division at SLAC National Accelerator Laboratory/Stanford 
University has an opening for a post-doctoral position. Our group works at the 
interface of computation and experiment to understand how proteins and ligands 
interact and function. For the successful candidate, there will be ample 
opportunity to get experience at the bench if desired.

Our research in computational structural biology and conformational dynamics 
centers on resolving spatiotemporally averaged data in ensemble experiments. 
Responsibilities for the position include developing novel computational, 
statistical and experimental methodologies to identify biomolecular ensembles 
and allosteric mechanisms from X-ray and electron sources, in close 
collaboration with the Fraser group at UCSF, leading academic groups at 
SLAC/Stanford, and our collaborators in the pharmaceutical industry. 
 
The position is for up to four years, and available immediately. Candidates 
must have a Ph.D. degree in a quantitative discipline, like computer science, 
applied mathematics, statistics, computational (bio)physics, or similar, and 
strong algorithm and software development skills (Python or C++). Demonstrated 
experience with X-ray crystallography/cryoEM data processing, or machine 
learning approaches would be a plus. 

SLAC National Accelerator Laboratory is a U.S. Department of Energy (DOE) 
Office of Science laboratory operated by Stanford University and has a unique 
set of large-scale facilities including the Linac Coherent Light Source (LCLS) 
X-ray Free-Electron Laser, the SLAC cryo-EM facilities, the Stanford 
Synchrotron Radiation Lightsource (SSRL), and state-of-the-art High-Performance 
Computing facilities. 

Come join us in sunny California!

Inquiries or applications, including a CV with publication list and two 
references to:
Henry van den Bedem (vdbe...@slac.stanford.edu)

[ccp4bb] Post-doc position at the University of Milan

[stefano]

Dear BB readers,

I am  currently looking for a motivated candidate for a 3-year Postdoctoral 
position in my lab at the Department of Bioscience, University of Milan.

The contract should start in January 2018.

The project will be focusing on structural and biophysical studies of 
neuroserpin, a human protein forming pathologic polymers. The effects of

glycosylation, of inhibitors and of mutations on polymer formation will be 
investigated both from the structural and biophysical point of view.

Strong background in structural biology, in protein expression (prokaryotic and 
eukaryotic) and protein purification are necessary.

Experience in spectroscopic techniques and in protein aggregation (amyloid 
formation etc..) are very welcome.

Fluent English is required.

If you want to know more about the project do not hesitate to contact me


Any interested candidate should send a short CV (two pages max) and two 
references to

this address

 ciciu...@hotmail.com

best

Stefano Ricagno

Stefano Ricagno, PhD

Associate Professor

Dept. of Bioscience

University of Milano

Via Celoria, 26. I-20133 Milano (Italy)

Tel. +39 02 5031 4914

http://users.unimi.it/stericagno/default.html

www.bioscienze.bio

[ccp4bb] Post-Doc position in Structural Biology, Bourne Lab @ University of Oklahoma, Norman OK

[Christina Bourne]

Postdoctoral Position in Structure-Function Studies of Toxin-Antitoxin 
Systemsat the University of Oklahoma, Norman OK TheBourne lab at the University 
of Oklahoma seeks to recruit a postdoctoralscientist with experience in 
Biochemistry and/or MacromolecularCrystallography and interests in bacterial 
physiology and/or microbial genetics.  The lab works on bacterial 
toxin-antitoxin (TA)systems and their physiological significance with a goal of 
identifying newantibacterial targets.  Current projectsinclude probing the 
structure and function of diverse TA sequences, anddeveloping screening 
methodology for understanding the roles of TA systemswithin bacterial 
physiology. For more information see the lab website at 
http://bournelab.oucreate.com/.  Weare seeking highly motivated postdoctoral 
scientists that adapt quickly andare results-oriented to be part of our growing 
team.  These individuals should be efficient atmulti-tasking, able to manage 
details of their own work and of students intheir training, able to communicate 
openly and confidently, to be persistent intheir research, and to trouble-shoot 
problems as they arise.  The successful candidates should haveexperience in 
cloning, and protein expression and purification; additionalexperience in 
protein crystallization and structure determination, biophysicalbiochemistry, 
and/or the analysis of protein interactions will be an asset.  The successful 
applicants must have a strongwork ethic and are expected to be productive 
members of the research team. Theinitial appointment will be for one year 
subject to satisfactory performanceand available funding.  Applications or 
inquiriesshould be sent to Dr. Christina Bourne by email at cbourne (at) ou 
(dot)edu.  Applicants should send a single PDFdocument containing: (1) a CV, 
highlightingyour contributions to research activities, and (2) the contact 
details forthree professional references. Applications will be accepted until 
the position is filled.  The University of Oklahoma is an equalopportunity 
employer, and applications from under-represented groups areencouraged.

   

[ccp4bb] Post-doc position at UTMB to study structural basis of neurodegenerative disease

[Morais, Marc C.]

Post-doctoral position open immediately at UTMB to study the structural biology 
of neurodegenerative disease

A postdoctoral position in structural biology is available to study the role of 
protein tau in neurodegenerative diseases at the University of Texas Medical 
Branch, in Galveston, TX. This NIH-funded position will utilize a combination 
of cryo-electron microscopy, tomography, X-ray crystallography, SAXS, and 
biochemistry to investigate the structures of protein tau assemblies and the 
mechanism of tau-related neuropathies. The successful candidate will report to 
Dr. Marc Morais and Dr. Rakez Kayed, experts in structural biology and 
tau-related neurodegenerative diseases, respectively. Experience in either 
X-ray crystallography or cryo-electron microscopy is required.


Structural biology facilities at UTMB are outstanding (https://scsb.utmb.edu/). 
X-ray crystallography 
resources include two X-ray 
area detector systems, a Phoenix crystallization robot, a Minstrel crystal 
imaging robot, and an Alchemist liquid handling robot. CryoEM resources include 
a JEOL 2200FS cryo-EM microscope equipped with a DE20 direct electron detector 
for high-resolution imaging work, a cryo-capable JEOL 2100, an FEI vitrobot, 
and a BSL-3 room for viral and pathogen work. UTMB is also a member of high 
resolution cryoEM imaging consortia at the Baylor College of Medicine, and 
UCLA, which provide access to JEOL 3200 and Titan Krios microscopes, 
respectively.

Interested parties should send a CV, a brief statement of research interests, 
and a list of 2-3 references to both Dr. Marc Morais 
(mcmor...@utmb.edu) and Dr. Rakez Kayed 
(raka...@utmb.edu).





Marc Morais
Associate Professor
Dept. of Biochemistry & Molecular Biology University of Texas Medical Branch
6.614B Basic Science Building 301 University Boulevard, Galveston, TX
77555-0647

[ccp4bb] Post-doc position in serial crystallography

[Joerg Standfuss]

Dear all,

A post-doc opportunity is available at the Paul Scherrer Institute in
Switzerland. We are looking for a young scientist with interest in serial
crystallographic data evaluation and processing. Within an
interdisciplinary team you will strengthen our efforts in time-resolved
crystallography of light-triggered membrane proteins at SwissFEL and other
free electron lasers.

Further information under:
http://www.psi.ch/pa/offenestellen/1041

Best Regards,
Joerg


***
Dr. Jörg Standfuss
Group Leader
Biomolecular Research
Paul Scherrer Institute
OFLC-103
5232 Villigen PSI
Switzerland

[ccp4bb] Post-doc position - Cryo-electron microscopy - University of Minnesota

[Wei Zhang]

 A post-doctoral scientist position is available at the University of
Minnesota, USA. The successful candidate will study the cell entry
mechanism of small-enveloped viruses using cryo-EM and cryo-ET methods. The
project focuses on understanding the oligomerizational and organizational
changes of the type-II fusion proteins during low-pH triggered membrane
fusion.

Candidates are expected to have a strong background in either of molecular
virology, protein structure determination, cryo-EM data collection, cryo-ET
data collection and image-processing. The successful candidate will be
involved in the specimen preparation and development of necessary
computational algorithms to facilitate image analysis. Other expectations
include high self-motivation, well-organized working style, good team work
ethics, preparation of research papers and presentations at professional
conferences.

Scientists recruited will work in state-of-the-art facilities and will join
a strongly interactive, collaborative and collegial research environment.
Minneapolis is a dynamic and progressive city with outstanding cultural
attractions and a high standard of living. Qualified applicants are invited
to submit a cover letter, current CV and the contact information for three
references to Dr. Wei Zhang (zhang...@umn.edu).

[ccp4bb] post-doc position in Oulu, Finland

[Petri Kursula]

Hi,

I’d like to bring the following position into the attention of any suitable 
candidates:

-

POSTDOCTORAL POSITION IN MOLECULAR MATERIALS RESEARCH, UNIVERSITY OF OULU, 
FINLAND

A two-year interdisciplinary postdoctoral position in molecular materials 
research is available in the Research Community of Molecular Materials 
(http://www.oulu.fi/molecularmaterials/node/25636 
) at the University of Oulu 
(http://www.oulu.fi/english ), Finland. The 
community consists of seven research groups in physics, biophysics, 
nanotechnology, chemistry and biochemistry, and pursues both experimental and 
theoretical/computational work. The successful applicant will conduct research 
in tight association with at least two of the participating groups. The 
specific requirements, the contact information of the groups, and the 
instructions for applying can be found in 
https://www.saimanet.com/certiahome/open_job_view.html?did=5600&jc=1&id=867&lang=en
 

 . The deadline for applications is April 7, 2015.

-


Best regards,
Petri

Petri Kursula, PhD
--
Professor of Biochemistry and Molecular Biology
Department of Biomedicine
University of Bergen, Norway
http://www.uib.no/en/persons/Petri.Kursula
petri.kurs...@biomed.uib.no
--
Project Leader, Docent
Faculty of Biochemistry and Molecular Medicine
Biocenter Oulu
University of Oulu, Finland
petri.kurs...@oulu.fi
--

[ccp4bb] Post-doc position - membrane protein complex

[Leonid Sazanov]

A candidate is thought for a two-year position (an extension is possible) to 
work on structural characterisation of respiratory complex I from T. 
thermophilus.

Complex I is central to bioenergetics – it is the first and largest enzyme of 
the respiratory chain in mitochondria and bacteria. It is also involved in a 
wide range of human diseases. We use the bacterial enzyme as a ‘minimal’ model 
of the more elaborate mammalian complex I. We have determined, by X-ray 
crystallography, all currently known atomic structures of complex I, starting 
with the hydrophilic domain (Science 2005, 2006), followed by the membrane 
domain (Nature 2010, 2011) and, finally, the recent (Nature 2013) structure of 
the entire Thermus thermophilus complex (536 kDa, 16 subunits, 9 Fe-S clusters, 
64 TM helices). Structures suggest a unique mechanism of coupling between 
electron transfer in the hydrophilic domain and proton translocation in the 
membrane domain, via long-range (up to ~200 Å) conformational changes. 

In order to determine the intriguing coupling mechanism, we are now working on 
the structures of the complex in different redox states, with various bound 
substrates. We are also interested in establishing the mode of action of 
various inhibitors of complex I. The post holder will be involved in taking 
this challenging project further, which requires extensive experience in 
protein purification and X-ray crystallography, preferably acquired working 
with membrane proteins or macromolecular assemblies. The post is partly funded 
via collaboration with Pharma. Initially several months will be spent training 
in the MRC Mitochondrial Biology Unit in Cambridge, UK and then the project 
will be moved together with the rest of the group to the Institute of Science 
and Technology in Austria, near Vienna.  IST Austria is a new institute 
dedicated to basic research, providing world-class research environment and 
benefits. We are looking to fill the post by early 2015. All queries and 
applications with CVs and names of 2-3 academic referees should be forwarded to 
Dr. Leonid Sazanov (saza...@mrc-mbu.cam.ac.uk).

[ccp4bb] Post doc position in structural biology at the University of Copenhagen

[Jette Sandholm Jensen Kastrup]

Post doctoral position - Structural studies of full-length glutamate receptors

The Department of Drug Design and Pharmacology, Faculty of Health and Medical 
Sciences at the University of Copenhagen is offering a two-year post doctoral 
position within "Structural studies of full-length glutamate receptors" 
commencing 1 January 2015.

Job description
The position will be anchored at the Biostructural Research section, Department 
of Drug Design and Pharmacology, University of Copenhagen. The Biostructural 
Research section provides the foundation for structural and functional studies 
of a wide range of different proteins involved in health and disease.

Ionotropic glutamate receptors (iGluRs) play a key role in fast excitatory 
synaptic transmission in the central nervous system. These receptors are 
critically important for normal brain function, such as learning and memory 
formation, whereas dysfunction in glutamatergic transmission has severe 
consequences on normal brain function, leading to disorders or diseases 
including Alzheimer’s disease and epilepsy. The aim of the research project is 
to explore conformational stages of iGluRs at the molecular level using 
primarily X-ray crystallography. Such information will facilitate 
structure-based drug design.

The successful applicant is expected to teach up to 10% of her/his time in 
areas relevant to the research project.

Qualifications required
The successful applicant would be an experimentally skilled scientist who can 
document original scientific production in the areas of membrane protein 
expression using eukaryotic cells and subsequent purification for structural 
studies. Experience with expression of receptors in insect cells as well as 
X-ray crystallography is an advantage.

Further information
For further information, please contact Professor Jette S. Kastrup 
(j...@sund.ku.dk, tel. +45 3533 6486).

Terms of employment
The terms of employment and payment are according to the agreement between the 
Ministry of Finance and The Danish Confederation of Professional Associations 
on Academics in the State.

As an equal opportunities employer, the University of Copenhagen encourages all 
qualified applicants to apply, regardless of gender, age, religion and ethnic 
origin.

Application
Applications should include the following parts:

1) Application cover letter indicating motivation
2) Curriculum vitae
3) Copies of relevant diplomas
4) A complete list of publications indicating articles relevant to the 
position, including copies of these articles (max. 5)
5) Recommendation letters if relevant

The parts must be clearly labeled with the above-mentioned numbers.

Applications will not be taken into consideration, if the requirements listed 
above are not met.

The application will be assessed according to the Ministerial Order no. 242 of 
13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen encourages all interested in this position to 
apply.

Please submit the application with the required attachments by clicking on 
"apply online" below. Only online applications will be accepted. The closing 
date for applications is 1st November 2014.

Applications received after the deadline will not be considered.

The Faculty of Health Sciences comprises app. 7500 students, app. 1500 PhD 
students and app. 3200 employees. The Faculty creates new knowledge and 
recognition through its core activities: research, teaching, knowledge sharing 
and communication. With basic research fields ranging from molecular studies to 
studies of society, the Faculty contributes to a healthy future through its 
graduates, research findings and inventions for the benefit of patients and the 
community.

Apply online

The University of Copenhagen actively influences current and future generations 
through excellent research, education and co-operation. UCPH is one of the 
highest ranked universities in Europe and is Denmark´s oldest university, 
founded in 1479. Today, the University has 37,000 students and 9,000 employees 
affiliated across six faculties: humanities, law, natural sciences, social 
sciences, health sciences and theology. www.ku.dk/english/.







Professor Jette Sandholm Kastrup
Head of GluTarget (www.glutarget.ku.dk)
Biostructural Research (www.farma.ku.dk/BR)
Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 2
DK-2100 Copenhagen
Denmark
Phone: +45 3533 6486
Email:j...@sund.ku.dk

[ccp4bb] Post-doc position in Leeds

[Neil Ranson]

Dear All,

A 3- year post-doctoral position is available immediately to work on the 
structural biology of ssRNA viruses and their assembly in my lab at the 
University of Leeds.  We already have several structures determined by cryo-EM 
and single particle image processing, at resolutions ranging from 6 to 3.2Å , 
so the system is up, running and ready to go, and highly likely to generate 
very high quality structural data. The project will therefore suit someone with 
a strong interest in structural biology, and in pushing the resolution of EM 
structures to the limit.

Please see: 
http://www.nature.com/naturejobs/science/jobs/438587-post-doctoral-research-fellow-structural-biology-of-ssrna-viruses

For more details, or to apply go to http://jobs.leeds.ac.uk, reference FBSFO0064

Informal enquiries, e.g. About the facilities & environment in Leeds, more 
details on the project, start dates etc, please contact me directly for a chat.

All the best,

Neil Ranson


Astbury Centre for Structural Molecular Biology
School of Molecular and Cellular Biology
University of Leeds
LS2 9JT. UK.

Astbury 8.108
E: n.a.ran...@leeds.ac.uk
T: +44 113 343 7065

[ccp4bb] Post doc position at the University of Copenhagen

[Jette Sandholm Jensen Kastrup]

Post doctoral position - Structural studies of full-length membrane-bound 
receptors and transporters

The Department of Drug Design and Pharmacology, Faculty of Health and Medical 
Sciences at the University of Copenhagen is offering a two-year post doctoral 
position within "Structural studies of full-length membrane-bound receptors and 
transporters" commencing 1st September 2014 or soon thereafter. The 
postdoctoral position is part of the interdisciplinary research program 
"Fertilizing the ground and harvesting the full potential of the new neutron 
and X‐ray research infrastructures close to Copenhagen University (Co-NEXT)" 
funded by the UCPH Excellence Program for Interdisciplinary Research.

Job description
The position will be anchored at the Biostructural Research section, Department 
of Drug Design and Pharmacology, University of Copenhagen. The Biostructural 
Research section provides the foundation for structural and functional studies 
of a wide range of different proteins involved in health and disease.

The aim of the research project is to express and purify different mammalian 
membrane proteins from insect cells following already existing protocols and 
establish nano disc reconstitution. This project will be part of research 
collaboration with the Niels Bohr Institute, University of Copenhagen. The 
project aims at employing SANS and SAXS to capture functionally important 
structural states of the target proteins. Such information will facilitate 
structure based drug design.

The successful applicant is expected to teach up to 10% of her/his time in 
areas relevant to the research project.

Qualifications required
The successful applicant would be an experimentally skilled scientist who can 
document original scientific production in the areas membrane protein 
expression using eukaryotic cells and subsequent purification for structural 
studies. Experience with protein reconstitution in to nano discs is an 
advantage.

Further information
For further information, please contact Professor Jette S. Kastrup 
(j...@sund.ku.dk, tel. +45 3533 6486 or Associate 
professor Osman Mirza (o...@sund.ku.dk, tel. +45 3533 
6175).

Terms of employment
The terms of employment and payment are according to the agreement between the 
Ministry of Finance and The Danish Confederation of Professional Associations 
on Academics in the State.

You can read more about the Faculty´s appointment procedures at:
http://pharmaschool.ku.dk/

As an equal opportunities employer, the University of Copenhagen encourages all 
qualified applicants to apply, regardless of gender, age, religion and ethnic 
origin.

Application
Applications should include the following parts:

1) Application cover letter indicating motivation
2) Curriculum vitae
3) Copies of relevant diplomas
4) A complete list of publications indicating articles relevant to the 
position, including copies of these articles (max. 5)
5) Recommendation letters if relevant

The parts must be clearly labeled with the above-mentioned numbers.

Applications will not be taken into consideration, if the requirements listed 
above are not met.

The application will be assessed according to the Ministerial Order no. 242 of 
13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen encourages all interested in this position to 
apply.

Please submit the application with the required attachments by clicking on 
"apply online" below. Only online applications will be accepted. The closing 
date for applications is 1st June 2014.

Applications received after the deadline will not be considered.

The Faculty of Health Sciences comprises app. 7500 students, app. 1500 PhD 
students and app. 3200 employees. The Faculty creates new knowledge and 
recognition through its core activities: research, teaching, knowledge sharing 
and communication. With basic research fields ranging from molecular studies to 
studies of society, the Faculty contributes to a healthy future through its 
graduates, research findings and inventions for the benefit of patients and the 
community.

Apply 
online

The University of Copenhagen actively influences current and future generations 
through excellent research, education and co-operation. UCPH is one of the 
highest ranked universities in Europe and is Denmark´s oldest university, 
founded in 1479. Today, the University has 37,000 students and 9,000 employees 
affiliated across six faculties: humanities, law, natural sciences, social 
sciences, health sciences and theology. www.ku.dk/english/.


Professor Jette Sandholm Kastrup
Head of GluTarget (www.glutarget.ku.dk)
Biostructural Research (www.farma.ku.dk/BR)
Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 2
DK-2100 

Re: [ccp4bb] Post-Doc Position Available at the Weizmann Institute of Science

[Joel Sussman]

Post-Doc Position: Structure-aided redesigning of an enzyme: molecular biology, 
protein expression/purification & crystallography

Immediate opening, in the Sussman lab at the Weizmann Institute of Science,  
for a postdoctoral fellow with experience in cloning and in protein expression, 
purification and characterization. Interest or experience in protein 
crystallography would be an advantage. The appointment will be for 2-3 years, 
and the project, which will focus on structure-aided redesigning of an enzyme, 
will be implemented in close collaboration with Prof Dan Tawfik (Dept of 
Biological Chemistry) and the Israel Structural Proteomics Center (ISPC).

-
Prof. Joel L. Sussman 
joel.suss...@weizmann.ac.il
Pickman Prof. of Structural Biology   +972 (8) 934 4531 - tel
Head, The Israel Structural Proteomics Center (ISPC)  +972 (8) 934 6312 - fax
Department of Structural Biology  
www.weizmann.ac.il/~joel
Weizmann Institute of Science 
www.weizmann.ac.il/ISPC
Rehovot 76100 ISRAEL  
proteopedia.org
-

[ccp4bb] Post-doc position for SAXS at the MAX IV Laboratory

[Marjolein Thunnissen]

The MAX IV laboratory in Lund has opened a position for a Postdoctoral fellow 
to strengthen the biological SAXS environment at the current SAXS beam line at 
the MAX-II ring. The position will be for two years and is embedded in the 
BIOSTRUCT-X EU program.

Full information of the position is available at: 
http://admin.lu.se/o.o.i.s?id=22598&Dnr=554436&Type=E. More information can be 
obtained from Tomás Plivelic 
(tomas.plive...@maxlab.lu.se).  Information 
about the MAX IV laboratory can be obtained at the homepage 
www.maxlab.lu.se .


best regards

Marjolein Thunnissen


 Marjolein Thunnissen Phone +46-(0)76-632 0417
 Associate Professor  Fax   +46-(0)46-22 24692
 Dept of Biochemistry and Structural Biology, Lund University
http://www.mps.lu.se
 PO-Box 124 S-221 00 Lund, Sweden

Scientific coordinator MX (The MAX IV Laboratory): I911 and BioMAX

[ccp4bb] Post-doc position for SAXS at the MAX IV Laboratory

[Marjolein Thunnissen]

The MAX IV laboratory in Lund has opened a position for a Postdoctoral fellow 
to strengthen the biological SAXS environment at the current SAXS beam line. 
The position will be for two years and is embedded in the BIOSTRUCT-X EU 
program.

Full information of the position is available at: 
http://admin.lu.se/o.o.i.s?id=22598&Dnr=554436&Type=E  as well as who to 
contact for more information. Information about the MAX IV laboratory can be 
obtained at www.maxlab.lu.se .


best regards

Marjolein Thunnissen


 Marjolein Thunnissen Phone +46-(0)76-632 0417
 Associate Professor  Fax   +46-(0)46-22 24692
 Dept of Biochemistry and Structural Biology, Lund University
http://www.mps.lu.se
 PO-Box 124 S-221 00 Lund, Sweden

Scientific coordinator MX (The MAX IV Laboratory): I911 and BioMAX

[ccp4bb] post-doc position @ Portugal on drug-design

[Teresa Santos Silva]

The Associate Laboratory REQUIMTE-CQFB, from Faculdade de Ciências e
Tecnologia, Universidade Nova de Lisboa (https://www.fct.unl.pt/en) is
opening a post-doc position to integrate a multidisciplinary team in
Structural Biology. The applicant must have a PhD in biochemistry, biology
or related fields and preference will be given to demonstrated experience
in protein crystallography and small molecules crystallography.

Contract: Initial duration is 3 months, renewable for additional 12 months,
with starting date predicted for 1st of September of 2013.

Monthly Stipend: According to the amounts stipulated by FCT (www.fct.pt)
for Research Grants in Portugal - 1495,00€

Job description: The main purpose of the work is to structurally
characterize at the molecular level the interaction of plasma proteins
(human serum albumin and human transferrin) with potential drugs (CORMs).
These are CO releasing molecules that have demonstrated therapeutic effects
in several models of disease (inflammation, apoptosis, cell proliferation,
among others) (Santos-Silva, JACS 2011, Curr Med Chem 2011; Santos, J Inorg
Biochem 2012; Seixas, Dalton Trans. 2012).

Biochemical and crystallographic studies, in combination with theoretical
calculations, will be performed, in the Protein Crystallography lab of the
Chemistry Department from Faculdade de Ciências e Tecnologia of
Universidade Nova de Lisboa (Lisbon-Caparica, Portugal) under the
supervision of Doctor Teresa Santos Silva and Prof. Maria João Romão (
http://xtal.dq.fct.unl.pt). The work is part of an on-going collaboration
with Prof. Carlos Romão from ITQB-UNL(Oeiras, Portugal) (www.itqb.unl.pt),
and the Pharmaceutical company Alfama.

Deadline for application: 15 July 2013

Applications should include: motivation letter, Curriculum Vitae, names and
emails of 2 possible referees, copy of the degree certificate as well as
other documents considered to be relevant, and sent to Dr Teresa
Santos-Silva, t...@fct.unl.pt.

Please go to the following website to find about further details on this
application and project:

http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=37399


Applications must be sent to t...@fct.unl.pt

[ccp4bb] Post-doc position available at University of Texas Medical Branch

[Choi, Kyung]

A post-doctoral position is available in Dr. Kay Choi’s laboratory at the 
University of Texas Medical Branch for either an X-ray crystallographer or a 
Biochemist to study the structure and mechanism of viral replication complexes. 
 We use a combination of X-ray crystallography, cryo-electron microscopy, 
protein chemistry, and bioinformatics to determine the structure of viral 
replication machinery and to develop antiviral therapeutics.

The X-ray crystallography resources include two X-ray area detector systems, a 
Phoenix crystallization robot, a Minstrel crystal imaging robot, and an 
Alchemist liquid handling robot.  The cryoEM facility includes two JOEL 200 keV 
cryoEM microscopes for high-resolution imaging work, FEI vitrobot, and a BSL-3 
room for viral and pathogen work.


Applicants should possess a PhD in structural biology or biochemistry with a 
sound knowledge of protein purification.  Individual with a biochemistry 
background who wishes to gain expertise in structural biology is encouraged to 
apply.   Interested parties should send a cover letter, a CV and a list of 2-3 
references to Dr. Kyung (Kay) Choi via e-mail at 
kyc...@utmb.edu.



Kay Choi
Assistant Professor
Department of Biochemistry and Molecular Biology
6.614C Basic Science phone 
: 409-747-1402
The University of Texas Medical Branch fax : 
409-747-1404
301 University Blvd.  
email : kay.c...@utmb.edu
Galveston, TX 77555-0647

[ccp4bb] Post-doc position in human ion channel structure/function studies at the SGC in Oxford

[Liz Carpenter]

We are seeking an enthusiastic and experienced membrane protein structural 
biologist with a strong interest in ion channel structure and function, to join 
the integral membrane proteins group at the Structural Genomics Consortium in 
Oxford. This post-doc position will involve purification, crystallisation, 
structure determination and functional studies of human ion channels and other 
membrane proteins.
For more information please see:  
http://www.thesgc.org/careers/oxford/postdoc-imp
or contact Liz Carpenter 
(liz.carpen...@sgc.ox.ac.uk)  for informal 
enquiries.
To apply for this position please follow this link:
https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=105253

The closing time/date for this post is 12 noon on the 3rd of December, 2012.
With best wishes,
Liz Carpenter,

Dr Liz Carpenter,
Principal Investigator, Integral Membrane Proteins group,
Structural Genomics Consortium,
Old road Campus Research Building,
Old Road Campus,
Roosevelt Drive,
Oxford,  OX3 7DQ, UK
Phone: +441865617581


Structural Genomics Consortium,
Old road Campus Research Building,
Old Road Campus,
Roosevelt Drive,
Headington,
Oxford,
OX3 7DQ,
England.

[ccp4bb] Post-Doc position at Diamond Light source

[Martin Walsh]

Dear all - this is a reminder for the Postdoc post detailed below - closing 
date is THIS FRIDAY
- don't hesitate to contact me directly for more information. Application 
details can be found on the Diamond web pages 
(http://www.diamond.ac.uk/Home/Jobs/Current/DIA0766_TH.html)
Martin
===
Post-Doctoral Research Associate - Macromolecular Crystallography
Job Reference

DIA0766/TH

Post Type

Full time / 3 year fixed term

Division

Science

Salary information

£28,409 - £35,629; starting salary, dependent on assessment of previous 
relevant experience and qualifications

Application deadline

5th October 2012


Date interviews


19th OCTOBER 2012


Duties
Diamond Light Source is the UK's national synchrotron science facility. Located 
at Harwell Science & Innovation Campus in Oxfordshire, we enable world-leading 
research across a wide range of scientific disciplines and industrial 
applications..
We are looking for a highly motivated and experienced structural biologist at 
the Post Doctoral Research Associate level to join a multidisciplinary 
collaboration formed by groups located at the central laser facility within the 
Research complex at Harwell, Diamond and the Universities of Strathcylde and 
Nottingham. The post will be based within the group of Martin Walsh at Diamond.

The aim of the project is to combine X-ray crystallography, time resolved 2D-IR 
spectroscopy and biochemical techniques to study the structure and function of 
targeted bacterial sensors of nitric oxide.

The project will involve elements of biochemistry, structural biology and 
infrared spectroscopy, including time resolved and multidimensional methods. 
Expertise in all areas is not required, though a strong background in cloning 
and overproduction of proteins for structural studies is advantageous. The 
successful candidate will join ongoing collaborative projects in place between 
Strathclyde, Diamond, Nottingham and the Research Complex at Harwell  that aim 
to investigate the mechanisms of protein systems from a multidisciplinary 
perspective. Regular interactions with Strathclyde and the Research Complex are 
envisaged. As such the project will suit an ambitious and motivated candidate 
with a strong commitment to multidisciplinary research.


Qualifications and Experience: Essential

  *   PhD in biochemistry or related disciplines; or equivalent qualification 
or experience;
  *   Experience in cloning and recombinant expression of proteins for 
structural studies
  *   Sound understanding of methods, systems and approaches relating to 
macromolecular crystallography;
  *   Good laboratory research skills;
  *   Good interpersonal, communication and presentational skills;
  *   Good problem solving skills;
  *   Ability to plan and carry out a research project;
  *   Ability to interact effectively with staff at all levels;
  *   Ability to work on own initiative and take personal responsibility for 
delivery of work;
  *   Must be available to travel occasionally within the UK and abroad, 
including overnight absences.
Qualifications and Experience: Desirable

  *   Expertise in single crystal protein structure solution
  *   Experience or knowledge of synchrotrons and diffraction experiments;
Further Information

  *   Candidates are encouraged to contact Dr. Martin Walsh 
(martin.wa...@diamond.ac.uk) for further 
details on the responsibilities and research associated with the post.
Applying for employment
For further details on applying for employment at Diamond, please visit our 
'Application Form' page.






-- 

This e-mail and any attachments may contain confidential, copyright and or 
privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.

Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 

Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.

Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom

 

[ccp4bb] Post-Doc position at Diamond Light Source

[Martin Walsh]

Dear all - see below for a postdoc position available immediately at Diamond - 
don't hesitate to contact me directly for more information. Application details 
can be found on the Diamond web pages 
(http://www.diamond.ac.uk/Home/Jobs/Current/DIA0766_TH.html)
Martin
===
Post-Doctoral Research Associate - Macromolecular Crystallography
Job Reference

DIA0766/TH

Post Type

Full time / 3 year fixed term

Division

Science

Salary information

£28,409 - £35,629; starting salary, dependent on assessment of previous 
relevant experience and qualifications

Application deadline

5th October 2012

Date of interviews

TBC


Duties
Diamond Light Source is the UK's national synchrotron science facility. Located 
at Harwell Science & Innovation Campus in Oxfordshire, we enable world-leading 
research across a wide range of scientific disciplines and industrial 
applications..
We are looking for a highly motivated and experienced structural biologist at 
the Post Doctoral Research Associate level to join a multidisciplinary 
collaboration formed by groups located at the central laser facility within the 
Research complex at Harwell, Diamond and the Universities of Strathcylde and 
Nottingham. The post will be based within the group of Martin Walsh at Diamond.

The aim of the project is to combine X-ray crystallography, time resolved 2D-IR 
spectroscopy and biochemical techniques to study the structure and function of 
targeted bacterial sensors of nitric oxide.

The project will involve elements of biochemistry, structural biology and 
infrared spectroscopy, including time resolved and multidimensional methods. 
Expertise in all areas is not required, though a strong background in cloning 
and overproduction of proteins for structural studies is advantageous. The 
successful candidate will join ongoing collaborative projects in place between 
Strathclyde, Diamond, Nottingham and the Research Complex at Harwell  that aim 
to investigate the mechanisms of protein systems from a multidisciplinary 
perspective. Regular interactions with Strathclyde and the Research Complex are 
envisaged. As such the project will suit an ambitious and motivated candidate 
with a strong commitment to multidisciplinary research.
Qualifications and Experience: Essential

  *   PhD in biochemistry or related disciplines; or equivalent qualification 
or experience;
  *   Experience in cloning and recombinant expression of proteins for 
structural studies
  *   Sound understanding of methods, systems and approaches relating to 
macromolecular crystallography;
  *   Good laboratory research skills;
  *   Good interpersonal, communication and presentational skills;
  *   Good problem solving skills;
  *   Ability to plan and carry out a research project;
  *   Ability to interact effectively with staff at all levels;
  *   Ability to work on own initiative and take personal responsibility for 
delivery of work;
  *   Must be available to travel occasionally within the UK and abroad, 
including overnight absences.
Qualifications and Experience: Desirable

  *   Expertise in single crystal protein structure solution
  *   Experience or knowledge of synchrotrons and diffraction experiments;
Further Information

  *   Candidates are encouraged to contact Dr. Martin Walsh 
(martin.wa...@diamond.ac.uk) for further 
details on the responsibilities and research associated with the post.
Applying for employment
For further details on applying for employment at Diamond, please visit our 
'Application Form' page.





-- 

This e-mail and any attachments may contain confidential, copyright and or 
privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.

Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 

Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.

Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom

 

[ccp4bb] Post-doc position available

[Meng-Chiao Ho]

Dear All,

The Ho lab at the Institute of Biological Chemistry of Academia Sinca in Taiwan 
seeks a motivated structural biologist at post-doctoral level with interest in 
structure and activity studies of pharmaceutically important enzymes.

The laboratory currently works on the structure/function studies of protein 
arginine methyltransferases and inhibitor design for glucuronidase and 
caspase-7.

Applicant should have a strong background in protein expression and 
purification. Some experience in protein crystallography is required. Candidate 
possessing experience in high-throughput protein production, protein thermal 
assay, or fragment-based screening are preferred. This position provides the 
opportunity or broad training in protein expression, crystallization, small 
angle X-ray scattering, NMR, enzymology and protein-protein interaction.

Applicants should submit the curriculum vitae and the names and contact 
information of three professional references via email to:  
sbddintai...@gmail.com

For more information about the lab, please visit  http://ho.ibc.sinica.edu.tw/
We are looking forward to receiving your application!

Joseph Ho

[ccp4bb] Post-doc position - Biophysics and RNA virus proteins

[Olve Peersen]

Post-doc in Peersen Laboratory
Biochemistry & Molecular Biology
Colorado State University

Post-doctoral fellow position in structural biology and biophysical studies of 
RNA virus replication. The projects are focused on the structures of viral 
RNA-dependent RNA polymerases, functional complexes involved in RNA synthesis, 
and the assembly of membrane anchored replication centers formed by single 
stranded RNA viruses.

The project will build on recent studies of viral elongation complexes to 
further our understanding of polymerase function and replication fidelity. 
Prior studies are described in Gong & Peersen, PNAS 107:22505, Hobdey et al., 
J. Virology 84:8072, and Nadig et al., PNAS+ (in press).  Previous experience 
in X-ray crystallography, RNA biochemistry, and/or fluorescence methods would 
be advantageous.


Job Requirements:
---
The position requires a Ph.D. at time of hire with prior experience in protein 
biochemistry, molecular biology, and/or biophysical methods.

Applications should be received by August 20, 2012 for full consideration.  
Interested individuals should submit a CV, statement of research and career 
interests, and contact information for three references at 


http://www.natsci.colostate.edu/employment/bmbPdoc/



CSU is an EO/EA/AA employer.  CSU conducts background checks on all final 
candidates.

[ccp4bb] Post-doc position - Umea University, Sweden

[Elisabeth Sauer-Eiksson]

A two year post-doctoral fellowship is available in the group of Elisabeth 
Sauer-Eriksson and Tobias Hainzl at Umea University, Sweden. 

The project will involve structural characterizations of RNA and RNA-protein 
complexes based on X-ray crystallographic methods. 

Ideally, the applicant should have experience in macromolecular 
crystallography, protein and RNA molecular biology, biochemistry, 
crystallization and structure determination.  

Closing date is August 9, 2012.


We are looking forward to receiving your application!

/Liz Sauer-Eriksson and Tobias Hainzl

For detailed information and application instructions, please visit 
http://www.umu.se/english/about-umu/news-events/grants/223-1440-12 

For informal enquiries please contact elisabeth.sauer-eriks...@chem.umu.se or 
tobias.hai...@chem.umu.se

[ccp4bb] Post-doc position in structural and biochemical analysis of novel antibacterial targets

[Peter Roach]

 Post-Doctoral Research Assistant in Biochemistry


   Molecular Diagnostics and Thereputics


 *University of Southampton*

*Location: *Highfield Campus

*Salary: * £27,578 to £33,884

Full Time Fixed Term

*Closing Date: * Tuesday 12 June 2012

*Interview Date: * To be confirmed

*Reference: *118112EB

The increase in bacterial resistance to antibiotic therapies has 
resulted in an expanding demand for novel therapeutics. Identification 
of new enzyme targets for the drug development pipeline is a particular 
priority. This project will be based in a research group with expertise 
in analysing enzyme structure and function including use of X-ray 
crystallography and development of high throughput assays for inhibitor 
discovery. The post, based in the Faculty of Natural and Environmental 
Sciences, Chemistry, will involve evaluation of selected bacterial 
enzymes as potential targets for antibacterial development, using a 
combination of enzymology and X-ray crystallography.  Excellent 
facilities for protein structure analysis and for high throughput 
chemical biology are available. The successful applicant will join a 
highly active research team working in related areas.


It is desirable that applicants hold a PhD in chemical biology, 
biochemistry or structural biology and a strong background in enzyme 
biochemistry and/or protein X-ray crystallography.


The appointment is initially for 12 months, with the possibility of 
renewal for a further 24 months. The proposed start date is July 2012 or 
as soon as possible thereafter.   Informal enquiries should be made in 
the first instance to Dr Peter Roach (email: p...@soton.ac.uk 
 tel: 023 8059 5919), Chemistry, University 
of Southampton.


Your completed application should include (i) the application form; (ii) 
your Curriculum Vitae; (iii) the names and addresses of two referees and 
should be copied by email to Dr Roach. (Our online application process 
will prompt you to include all the above).


The closing date for this position is 12 June 2012. Please apply online 
through www.jobs.soton.ac.uk  or 
alternatively telephone 023 8059 2750 for an application form. Please 
quote reference number 118112EB on all correspondence.


Further details: We aim to be an equal opportunities employer and 
welcome applications from all sections of the community. *Please note 
that applications from agencies will not be accepted unless indicated in 
the job advert.*


--
Dr. Peter L. Roach
Senior Lecturer in Chemical Biology
School of Chemistry
University of Southampton
Southampton SO17 1BJ, U.K.
Telephone 02380 595919
Email p...@soton.ac.uk

[ccp4bb] Post-doc position available

[Stewart Turley]

A  position is available now in the laboratory of Wim Hol, as described below.  Please respond to the address at the end of the advertisement.

Postdoctoral Position
Available 

Laboratory of Wim Hol

Department of Biochemistry,
School of Medicine

 University of Washington, Seattle, USA

 

Structural
Biology of the type II secretion system 

from
pathogenic bacteria 

 

    The projects in Wim Hol’s protein
crystallography group at the University of Washington are all focused on
providing a basis for development of new therapeutics for tropical diseases.
This particular available postdoctoral position is part of a major effort to
unravel the architecture, mechanism of action and biogenesis of the “type II
secretion system” (T2SS).  

 

The sophisticated T2SS occurs in many pathogenic bacteria.  This machinery is responsible for
translocating a wide variety of proteins in a folded state from the periplasm
across the outer membrane into the extracellular milieu. One of these proteins
is cholera toxin which has been studied intensively in the Hol lab. The large
T2SS consists of  multiple copies of  ~14 different proteins that span the inner and
the outer membrane, and is associated with 
a secretion ATPase in the cytoplasm which provides the energy for the
secretion process. Another remarkable feature of the T2SS is a helical sub-assembly
in the periplasm which is likely serving as a piston pushing cholera toxin and
other exoproteins through a pore in the outer membrane.

 

    The successful candidate will have
the opportunity to: 

(i) carry
out protein _expression_ and protein chemistry studies to obtain insight into
protein-protein interactions involving the T2SS from pathogenic bacteria like Vibrio cholera, enterotoxigenic E. coli, and other bacteria;

(ii)
purify and characterize multi-protein and multi-membrane protein complexes;

(iii)
determine high resolution crystal structures of these complexes; 

(iv) analyze
these structures and combine this with other biochemical data;

(v)
interact with several collaborating groups which are using other methods to
obtain structural and functional insight into the mechanism of this
sophisticated secretion system.

 

For more
information regarding the laboratory of Wim Hol see the following website:

http://www.bmsc.washington.edu/WimHol/

 

For more
information regarding the type II secretion system see our recent review:

Korotkov, K. V., Sandkvist, M. and Hol, W. G. J. 

The type II secretion system: biogenesis, molecular architecture
and mechanism.  Nature Reviews
Microbiology 10, 336-351 (2012)  

 

 

START
DATE: Immediately

 

INSTITUTION:    Department
of Biochemistry 

    Biomolecular Structure Center

    School of Medicine

    Box 357742

    University of Washington

    Seattle, WA, 98195  USA

 

 

Requirements

Experience
with membrane protein preparation, including molecular biology techniques, membrane
protein characterization and protein crystallography.

 

Application

If you are
interested, please send your CV, including a description of your experience and
technical know-how, a list of publications and presentations, and names and
email addresses of three references able to assess your scientific experience
and capabilities to: wg...@u.washington.edu

[ccp4bb] Post-Doc position at ICR, London

[Alessandro Vannini]

We seek to appoint a post-doctoral training fellow to the Division of 
Structural Biology in the new team led by Dr Alessandro Vannini to undertake 
crystallographic, single particle electron microscopy analysis and biochemical 
analysis of large macromolecular complexes that assemble at RNA Polymerase III 
loci across the eukaryotic genome, in order to mechanistically understand their 
role in cancer and other fundamental cellular processes 
(www.icr.ac.uk/alessandrovannini).

The Division of Structural Biology has managed facilities for protein 
crystallography (Bruker Microstar and CCD detector and crystallisation robots), 
cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with 
expertise in multi-subunit expression (insect cell, yeast and bacterial 
expression, including a 60 L fermentor). The Division is also well equipped 
with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle 
light scattering).

Applicants should possess a PhD (or equivalent) in biochemistry or molecular 
biology with a sound knowledge of protein crystallography an/or single particle 
electron microscopy. Experience in the biochemical and biophysical 
characterization of multi-subunit and protein-nuclei acids complexes is highly 
desirable. Experience in protein production in insect cells (MultiBac) or yeast 
genetics would be an advantage.

Appointment will be on Fixed Term Contract for 3 years in the first instance, 
with a starting salary in the range of £27,536 to £33,852 p.a. inclusive (based 
on previous post-doctoral experience).

For further particulars and details of how to apply, please check the current 
vacancies in the division of Structural Biology on our online application 
website (https://www.icr.ac.uk/jobs/index.shtml) and refer to this vacancy (n. 
1228522).

Closing date: 16th May 2012

Please direct informal inquiries to Dr. Alessandro Vannini at 
alessandro.vann...@icr.ac.uk

[ccp4bb] Post-Doc Position available at the BMLS, University Frankfurt, Germany

[Martin Grininger]

At the Buchmann Institute of Molecular Life Sciences (former Frankfurt  
Institute of Molecular Life Sciences; Goethe University  
Frankfurt/Main) there is an opening for a Post Doctoral Position (E13  
TV-G-U, fulltime). The position is available from April 1, 2012, and  
the initial appointment is for 1 year, with an option of extension for  
up to three years. Consideration of applications will continue until  
the position is filled.


The newly installed working group performs research on large  
multifunctional protein complexes. In projects funded by the  
Volkswagen Foundation, the German Research Foundation and the CEF  
Adjunct Investigatorship Program, structural analysis will be  
performed on fatty acid synthases and polyketide synthases. The  
successful post-doc candidate should be experienced in collecting and  
processing low resolution X-ray data, and in performing hybrid method  
approaches for structure solution by e.g. integrating electron  
microscopic data obtained in collaboration.


The Buchmann Institute for Molecular Life Sciences (BMLS) is a  
dedicated research institute and the candidate will be able to spend  
about 80% of his/her time in self-determined research in structural  
biology, particularly in X-ray crystallography, as well as in  
presentation and publication of scientific achievements. Additional  
tasks and duties are (20% of time): Contribution and acceptance of  
responsibility in co-supervision of PhD students and undergraduates,  
support in general tasks and duties of the working group, maintenance  
of scientific instruments and computers, and contribution in teaching,  
supervision of practical courses and supervision of students.


The BMLS is located at the Riedberg campus in the north of  
Frankfurt/Main. The building with its labs, facilities and offices is  
brand-new and extremely well equipped. The campus harbors the life  
science faculties of the university, lecture and library buildings,  
and the Max-Planck-Institutes of Biophysics and Brain Research  
comprising all disciplines and methods of life sciences. At this  
campus, the successful candidate finds an encouraging and inspiring  
atmosphere.


The successful candidate will join a small lab which is currently  
moving from the Max-Planck-Institute of Biochemistry  
(www.biochem.mpg.de/oesterhelt/grininger) to the BMLS  
(http://www.fmls-institute.de), and will approximately grow to a size  
of 5 to 8 people within this year.


If you are interested and highly motivated, submit your CV and further  
information (list of publications, contact of three referees, etc.)  
per e-mail to: grinin...@chemie.uni-frankfurt.de; Prof. M. Grininger,  
Goethe University Frankfurt, BMLS Building, Max-von-Laue-Str. 15,  
60438 Frankfurt.

[ccp4bb] Post-doc position on AMPA glutamate receptor structure/modulation at the MRC LMB Cambridge

[Ingo Greger]

A post-doctoral position in AMPA glutamate receptor biology (AMPA-Rs) is 
available in Ingo Greger's lab at the MRC LMB, Cambridge.
This post is funded by MRC-Technology and aims to develop AMPA-R modulators 
targeting the receptor's N-terminal domain (NTD).
We seek an experienced crystallographer with an interest in ion channels.
This is a multidisciplinary, collaborative project involving ligand-observed 
NMR screens, biophysical approaches, ligand evolution and AMPAR 
electrophysiology.

Sukumaran et al. 2011. EMBO J. 30, 972-82
Jensen et al. 2011. J. Mol. Biol. 414, 96-105
(Rossmann et al. 2011. EMBO J. 30, 959-71)

For further details please contact Dr. Ingo Greger at i...@mrc-lmb.cam.ac.uk
(http://www2.lmb.internal/group-leaders/a-to-g/i-greger)

[ccp4bb] Post-doc Position - Columbia University

[Liang Tong]

A Postdoctoral Research Associate position is available for the structural 
studies on enzymes involved in fatty acid metabolism or proteins involved in 
pre-mRNA 3'-end processing. We have extensive experience in these areas, and 
have generated many high-impact publications. Please see my home page for more 
information-

http://como.bio.columbia.edu/tong

Strong experience in protein biochemistry is required. Prior experience with 
X-ray crystallography is desirable. 

Please send CV and names of three references to me by email.


Prof. Liang Tong
Department of Biological Sciences
Columbia University
New York, NY 10027
Email: lt...@columbia.edu

[ccp4bb] post-doc position at SSRL

[van den Bedem, Henry]

Modeling Conformational Ensembles of Proteins and Complexes


A post-doctoral position with a focus on modeling conformational ensembles of 
proteins and complexes is available immediately in the Structural Genomics 
Division of Stanford Synchrotron Radiation Lightsource at the SLAC National 
Accelerator Laboratory (http://ssrl.slac.stanford.edu).

Macromolecules and assemblies are studied by a variety of experimental 
techniques, including protein crystallography and Small Angle X-ray Scattering. 
Nano-crystallography and single particle imaging data from the Linac Coherent 
Light Source (LCLS), a first-of-its-kind free electron laser, are also being 
targeted at these systems. Accurately modeling the conformational variability 
of macromolecules is essential to understanding their cellular function.

This position at the forefront of computational structural biology aims to 
develop advanced algorithms to fit domains or proteins to experimental data 
from multiple sources while allowing for significant conformational changes. 
The goal is to automatically compute 3-D models, and to provide structural 
insights into functionally relevant dynamics, especially for time-resolved 
experiments or a series of static structures. The position offers the 
opportunity to closely collaborate with the Stanford Computer Science 
Department and work with X-ray, SAXS and LCLS nanocrystallography data. SLAC 
houses ample computational resources. Funding is available for up to 3 years. 
The starting date is as soon as possible.

Candidates should have a recent PhD in computer science, applied mathematics, 
computational biology/crystallography or a related field with strong 
programming skills. Please send a CV, a short summary of your research 
experience and two letters of recommendation to Henry van den Bedem 
(vdbe...@slac.stanford.edu). Further details are available upon request.

Relevant publications:

Yao et al. Sampling-based exploration of folded state of a protein under 
kinematic and geometric constraints. Proteins: Structure, Function, and 
Bioinformatics (in press).

Fraser et al. (2011) Accessing protein conformational ensembles using 
room-temperature X-ray crystallography. PNAS 108:16247-16252

van den Bedem et al. (2009) Modeling discrete heterogeneity in X-ray 
diffraction data by fitting
multi-conformers. Acta Cryst. D65:1107-1117

[ccp4bb] Post-doc position available

[Karen Fulan Discola]

A 2-year postdoctoral position is available in the laboratory of Dr. A.
Dessen at the Institut de Biologie Structurale in Grenoble, France, to study
structure and function of new bacterial virulence factors.

The laboratory has state-of-the-art equipment for biochemistry and
crystallography studies, and the postdoctoral fellowship will involve
protein purification, crystallization, data collection at the synchrotron,
and structure solution and refinement.

The IBS is a member of the Partnership for Structural Biology and thus has
preferential access to equipment and techniques available on the PSB site,
which also includes the EMBL, the ILL, and the ESRF.

Any inquiries should be sent to andrea.des...@ibs.fr.

[ccp4bb] Post-doc position in Structural Biology of RNA decay components near Paris (France)

[Marc Graille]

Post-doctoral position in Structural biology of RNA decay components.

Location: Orsay, near Paris (45 minutes by regular trains), France



A 2,5 years post-doctoral position, funded by the ANR (Agence  
Nationale pour la Recherche), is available to study structural aspects  
of protein-protein and protein-RNA complexes involved in eukaryotic  
mRNA decay.


For this purpose, the successful candidate will combine structural  
biology methods (X-ray crystallography and small angle X-ray  
scattering) together with biophysical approaches (ITC, DSC, MALLS,  
fluorescence polarization, CD, …). All these technologies are  
currently available at the state-of the-art structural biology and  
biophysical platforms implemented in the host institute IBBMC  
(Institute for Biophysics and Molecular and Cellular Biochemistry,  
CNRS & University Paris-Sud), i.e. 3 nanodrop crystallization robots  
(Tecan, Cartesian and Mosquito), a Formulatrix crystal imager, an  
ITC200, an in-house SAXS apparatus, … . The lab is also well equipped  
for protein production in E. coli or eukaryotic systems (P. pastoris  
and baculovirus) and protein purification (several AKTA purification  
systems).


The project will be carried-out under the supervision of Dr Marc  
Graille at IBBMC (Orsay, Paris-Sud University, France) in close  
collaboration with Dr Dominique Durand (IBBMC) for SAXS studies and Dr  
Séraphin (IGBMC, Illkirch, France) for functional studies. For recent  
publications related to the subject by Dr Graille and co-workers, see  
van den Elzen et al; Nat. Struct. Mol. Biol, 2010; Henri J et al, J.  
Biol. Chem., 2010; Rispal D et al, RNA, 2011 & Liger D, et al, Nuc.  
Acids Res., 2011.


The IBBMC, an institute from CNRS and University Paris-Sud (one of the  
largest and most renowned French universities), is located in a green  
and timbered campus, 25km south from Paris. The lab is within 10  
minutes walk from the train station, with regular connections to Paris  
city centre (45 minutes). The IBBMC is 2km away from the recently  
built French synchrotron SOLEIL, where we have regular access to  
protein crystallography (Proxima-1) and SAXS (Swing) beamlines.


		The successful candidate will have a PhD in protein biochemistry,  
biophysics, or structural biology. He/she should express strong  
interest in working at the interface between physics and biology.  
Expertise in RNA production and purification will be very much  
appreciated.


Net annual salary: around 27,000€.

Starting from January 2012.

Duration: 30 months.

Applications (including CV, covering and reference letters) or  
information requests should be sent to Marc Graille (marc.grai...@u-psud.fr 
) and Dominique Durand (dominique.dur...@u-psud.fr) before 15th of  
September, 2011.




Dr Marc Graille, CR1-CNRS,
Equipe "Fonction et Architecture des Assemblages Macromoléculaires"
IBBMC, CNRS UMR8619, Bât. 430 Université Paris-Sud   91405 ORSAY
Tel: 33 (0)1 69 15 31 57 / Fax: 33 (0)1 69 85 37 15

[ccp4bb] Post-doc position in cryo-EM at Oxford

[Robert Gilbert]

A post-doctoral position, initially for two years, is open in the group of 
Robert Gilbert at the Division of Structural Biology, Oxford 
(http://www.strubi.ox.ac.uk).

We are using both X-ray crystallography and cryo-EM to determine the structures 
of macromolecules and macromolecular complexes involved in eukaryotic protein 
synthesis and its control at the post-transcriptional level. The postholder 
will primarily work on recoding of translation that produces -1 and +1 
frameshifts with their main focus being cryo-EM data collection and analysis. 

References: Nature (2006) 441, 244-247; Proc. Nat’l Acad. Sci. USA (2007) 104, 
5788-5793; Structure (2008) 16, 664-672; Structure (2010) 18, 257-264. 

For more information including application procedure see:
http://www.ox.ac.uk/about_the_university/jobs/research/index/250711/arrs8109/

Informal enquiries also welcome. Closing date 25th July.

Robert Gilbert

[ccp4bb] post-doc position MRC-LMB

[Sjors Scheres]

* MRC Laboratory of Molecular Biology *

We are looking for a postdoctoral scientist with a computational 
background to join the group of Sjors Scheres on the development of new 
statistical image processing approaches, such as maximum likelihood 
refinement, for cryo-electron microscopy. Our current research focuses 
on reliable structure determination of relatively small (~200-400 kDa) 
macromolecular complexes with no or low symmetry that may occur in 
multiple conformations. Collaborations with experimental groups form an 
essential part of our research.


You are highly motivated and have a PhD in structural biology, 
bioinformatics, image processing or a related subject, good 
communication skills and a strong analytical mind. You have excellent 
skills in scientific programming and algorithm development, and are keen 
to apply these to the area of structural biology.


For informal enquiries, please contact Sjors Scheres 
(sche...@mrc-lmb.cam.ac.uk), or 
visit http://www2.mrc-lmb.cam.ac.uk/groups/scheres for more information.


You will be awarded an MRC Career Development Fellowship, which is a 
three year training and development position for a postdoctoral 
scientist who has recently completed their doctoral studies or is moving 
into a new research discipline. Your salary will be supported by a 
flexible pay and reward policy, 30 days annual leave entitlement, an 
optional MRC final salary pension scheme and excellent on-site sports 
and social facilities.


Applications are handled by the RCUK Shared Services Centre; to apply 
please visit our job board at https://ext.ssc.rcuk.ac.uk and complete an 
online application form. Applicants who would like to receive this 
advert in an alternative format (e.g. large print, Braille, audio or 
hard copy), or who are unable to apply online should contact us by 
telephone on +44 (0)1793 867003. Please quote reference number IRC16187.


*Closing date: 29th March 2011*

--
Sjors Scheres
MRC Laboratory of Molecular Biology
Hills Road, Cambridge CB2 0QH, U.K.
tel: +44 (0)1223 402217
http://www2.mrc-lmb.cam.ac.uk/groups/scheres

[ccp4bb] Post-doc position at IBS, Grenoble

[Joanna TIMMINS]

Dear colleagues,

A post-doctoral position will be opened at the IBS in Grenoble (see 
below). I would be very grateful if you could forward the information 
below to potential candidates.


Post-doc position at the Institut de Biologie Structurale, Grenoble, France

*Structural Biology of DNA repair enzymes*

A post-doctoral position in Structural Biology is available at the IBS 
(www.ibs.fr ) in Grenoble. This position is funded 
for two years as part of a ATIP-AVENIR grant. I will be moving to IBS to 
start up my new research team in May 2011 and the post-doc position 
would be expected to start mid-2011.


Our research will focus on the study of essential DNA repair enzymes and 
more particularly on the dynamics of DNA repair and the mechanisms 
involved in DNA damage recognition. The research will entail the 
expression, purification and crystallisation of these key proteins, but 
also biochemical studies of these enzymes /in vitro/. Low and 
high-resolution studies will then be carried out on the proteins alone 
and in complex with their DNA substrates.


We are seeking an enthusiastic and dedicated individual to carry out 
this project. The ideal candidate has a PhD in Structural Biology, 
Biochemistry or equivalent with extensive experience in protein 
purification and protein crystallography. Additional experience in the 
study of protein-DNA interactions and/or eukaryotic cell expression 
would be a clear advantage.


Informal enquiries and applications in the form of a CV including 
publication list, short summary of research activities and contact 
details of two academic referees should be sent to the following 
address: timm...@esrf.fr . Deadline: 31^st March 
2011.


Joanna TIMMINS

--
Dr. Joanna Timmins
Structural Biology Group
ESRF
B.P. 220, 6 rue Jules Horowitz,
F-38043 Grenoble Cedex, France
Tel: (33) 4 76 88 25 63

[ccp4bb] Post Doc position in Molecular biology

[Preben Morth]

Dear ccp4bb
On behalf of Professor Geir Christensen I would like to draw your attention to 
a post position in molecular biology
http://uio.easycruit.com/vacancy/519990/70331?iso=no

Please contact Geir Christensen for further information
 

J. Preben Morth, Ph.D
Group Leader
Membrane Transport Group
Nordic EMBL Partnership
Centre for Molecular Medicine Norway (NCMM)
University of Oslo
P.O.Box 1137 Blindern
0318 Oslo, Norway

Email: j.p.mo...@ncmm.uio.no
Tel: +47 2284 0794

http://www.ncmm.uio.no/research/ncmm-embl-group-leaders/

[ccp4bb] Post Doc position in Structural Biology at the University of Warwick, UK

[David Roper]

Dear CCP4 bb

??I have a Post doc position available for a biochemist/structural biologist
with expertease in Protein crystallography at the University of Warwick in
the UK. 

The project is on aspects of peptidoglycan biosynthesis in Mycobacterium
tuberculosis in collaboration with Prof G.S. Besra at Birmingham University
who also has a position to offer for in a complimentary research position.

The closing date/time for applications is midnight (British time) at the end
of Tuesday 15 February 2011.

??Further details on the project and how to apply can be found at
http://www.jobs.ac.uk/job/ACD463/research-fellow/

Yours with thanks

Dr David I Roper
Associate Professor of Structural Biology
School of Life Sciences
University of Warwick
Gibbet Hill Road
Coventry
CV4 7AL
UK

Tel +44 (0)24 7652 8369/2568
Fax +44 (0)24 7652 3701
email: david.ro...@warwick.ac.uk
www.warwick.ac.uk/go/ropergroup

[ccp4bb] Post-doc position on Validation of Low-resolution Models

[Gerard DVD Kleywegt]

Hi all,

There is an EMBL Inter-disciplinary Post-doc (EIPOD) position available to 
work on "Validation of low resolution structural models". For details, see:


  http://www.embl.de/training/postdocs/eipod/app2011-1/svergun.pdf

The post-doc will be based at EMBL Hamburg and supervised jointly by Dmitri 
Svergun (EMBL Hamburg), Anne-Claude Gavin (EMBL Heidelberg) and Gerard 
Kleywegt (EMBL-EBI Cambridge).


For information on how to apply (as well as other available EIPOD positions), 
see:


  http://www.embl.de/training/postdocs/eipod/app2011-1/index.html

Best wishes,

--Gerard

---
Gerard J. Kleywegt, PDBe, EMBL-EBI, Hinxton, UK
ger...@ebi.ac.uk . pdbe.org
Secretary: Pauline Haslam  pdbe_ad...@ebi.ac.uk

[ccp4bb] Post-doc position available at the Sanford-Burnham Institute

[Fraydoon Rastinejad]

Postdoc: Protein Biochemistry, Protein Crystallography and Drug Discovery

We hare recruiting a Postdoctoral Associate in the area of nuclear hormone 
receptor biology and structural biology to join the Rastinejad lab at the 
Sanford‐Burnham Medical Research Institute in Orlando, Florida. The 
responsibilities will be to express  members of the nuclear receptor family of 
proteins and to conduct biochemical and cell-based assays searching for novel 
ligands, and to use protein crystallography / X-ray diffraction to understand 
stero-specific interactions. Applicant is expected to have solid previous 
background in the areas of cloning, protein expression and isolation, and with 
additional experience in X-ray crystallography.   Applicants: please make sure 
to forward 2-3 names for letters of reference from persons knowledgeable with 
your prior experience in science, together with your C.V. and cover letter to 
Ms. Stephanie Dickstein e‐mail address:
sdickst...@burnham.org

[ccp4bb] post doc position at NCMM in Olso, Structural Biology of membrane proteins

[J. Preben Morth]

Postdoctoral Research Fellow -

(Membrane Proteins Structural Biology)

Position as Postdoctoral Research Fellow - in membrane proteins  
structural biology


Ref.no.: 2010/ 8649

Available at the Centre for Molecular Medicine Norway (NCMM), Nordic  
EMBL Partnership, University of Oslo.


A post-doctoral position for an initial two years with possibility of  
extension is available in the laboratory of Dr. Preben Morth. The  
Postdoctoral position is funded by an NCMM grant and is available from  
the 1st of October. The Focus of the research will include membrane  
protein involved with osmoregualtion and anion transport in bacteria  
and higher eukaryotes. Projects focus on bicarbonate transport through  
the plasma membrane and the intra cellular complexes involved with  
their tight control.


NCMM, was established in 2007 as a partner institution of the European  
Molecular Biology Laboratory (www.embl.org). NCMM is located in brand  
new laboratories in the University of Oslo and National Hospital  
Biomedical Campus in the Oslo Research Park and Preclinical Medicine  
buildings. A new Structural Biology laboratory at NCMM, headed by Dr.  
J. Preben Morth has been established, with focus in membrane proteins.  
This new laboratory is well equipped for a modern approach to  
structural biology, it include recombinant expression in bacterial and  
eukaryotic systems, new protein purification equipment and incubators.  
There is excellent synchrotron access to ESRF through the Norwegian  
bag proposal.
The University of Oslo has an in-house mass spectroscopy department  
for fast protein identification, facilities for electrophysiology and  
visualization equipment with electron microscopy and confocal  
microscopy.


Applicants must have a PhD, and should have extensive experience with  
Vector design and cloning in E. coli and baculovirus or yeast  
expression systems, protein purification and characterization.   
Experience with membrane proteins and protein crystallography will be  
an advantage but not necessary. A good command of English is required.


Oslo is a vibrant city in the south of Norway, with ready access to  
skiing in the winter and hiking in the summer. The Oslo bay and most  
of the coastline offer excellent scuba diving opportunities.


For more information, please see the NCMM home page: http://www.ncmm.uio.no
Please also refer to the regulations pertaining to the conditions of  
employment for post-doctoral fellowship positions:

http://www.uio.no/admhb/reglhb/personal/tilsettingvitenskapelig/regulationstermcondition.xml
Salary:

Postdoctoral Research Fellow (SKO, 1352), pay grade: 57 – 64 (NOK 448  
200– 510 000 depending on experience and qualifications)


The application must include:

Application letter including a statement of interest, summarizing the  
applicant's scientific work and interests and describing how she/he  
fits the description of the person we seek
CV (summarizing education, positions, pedagogical experience,  
administrative experience and other qualifying activity), including a  
list of published and unpublished works
Copies of educational certificates, transcript of records, letters of  
recommendation
A complete list of publications and up to 5 academic works that the  
applicant wishes to be considered by the evaluation committee
Names and contact details of 2-3 references (name, relation to  
candidate, e-mail and telephone number)

Extended Applicant Form, to be filled in by the applicant
http://www.uio.no/om/jobb-ved-uio/ledige-stillinger/2010/vitenskapelige/sokerskjema_GBR.rtf
Closing date for applications:  15. August, 2010

The application should be sent electronically as a single pdf-file to recruitm...@ncmm.uio.no 
 labelled with Ref.no.: 2010/8649


The University of Oslo has an agreement for all employees, aiming to  
secure rights to research results a.o. The University of Oslo has a  
goal of recruiting more women in academic positions. Women are  
encouraged to apply. In accordance with the University of Oslo’s equal  
opportunities policy, we invite applications from all interested  
individuals regardless of gender or ethnicity.


Contacts:
Requests for application information should be directed to CAO Elin  
Kaurstad E-mail: e.k.kaurs...@ncmm.uio.no
Requests for further information and inquiries regarding the post can  
be directed to Group Leader J.Preben Morth, PhD. E-mail: j...@mb.au.dk
Please see the following URL for further details and guidelines for  
appointment to research fellowships at the University of Oslo:

http://www.matnat.uio.no/internt/administrasjonen/personal/Forskrifter-phd-postdoc-eng.pdf
The University of Oslo (UiO) wishes to achieve a more equal gender  
distribution of scientific staff. Female candidates are encouraged to  
apply.
UiO has an agreement for all employees, aiming to secure rights to  
research results a.o.

Jens Preben Morth, Ph.D
Aarhus University
Department of Molecular Biology
Gustav Wieds Vej

[ccp4bb] Post Doc position in Newcastle

[Richard Lewis]

Dear BBers

There is an ~18 month vacancy in my lab for a postdoc to work on
our favourite macromolecular complex, the 'stressosome'. The ideal
candidate will know their way around an Akta and be able to solve
crystal structures by isomorphous replacement and/or anomalous
scattering. Experience of linux system administration and/or
electron microscopic methods of single particles would be viewed
favourably.

Further details, and a link on how to apply for the post can be
found here:

http://tinyurl.com/25qpweg

The closing date is 2nd July 2010 and the position is available
immediately.

Please note that applications MUST be made through the website
and NOT emailed to me direct.

Cheers

Rick

[ccp4bb] Post-doc position Imperial College

[Byrne, Bernadette]

An RA position in membrane protein structural biology is available in the group 
of Dr Bernadette Byrne, Imperial College London. The position is funded for two 
years by GlaxoSmithKline as part of an industrial collaboration focusing on the 
structure determination of clinically relevant G-protein coupled receptors 
(GPCRs). The research will entail the expression, purification and 
crystallization of the GPCR targets.

The group is based at the South Kensington campus of Imperial College London 
and is fully equipped with a membrane protein structural biology research 
platform with excellent facilities and a stimulating research environment. It 
is expected that the successful candidate will also spend time working at 
GlaxoSmithKline, a short distance from London.

The ideal candidate has a PhD in Structural Biology, Biochemistry or equivalent 
and with well-documented experience in protein purification and protein 
crystallography while experience with membrane proteins would be an advantage. 
The position is available immediately.


Please forward informal inquiries and CVs including details of two academic 
referees to Dr Bernadette Byrne, 
b.by...@imperial.ac.uk. or Dr Julia Hubbard, 
julia.a.hubb...@gsk.com


Dr Bernadette Byrne
Senior Lecturer
Director of Postgraduate Studies
Division of Molecular Biosciences
Imperial College London
Exhibition Road
SW7 2AZ
Tel: +44 (0)20 7594 3004
Fax: +44 (0)20 7594 3122

[ccp4bb] Post-Doc position

[L. Wayne Schultz]

Hauptman-Woodward Medical Research Institute

Post-doctoral Positions

Virus-Host Interactions and Structures

The laboratories of Drs. L. Wayne Schultz and Tim Umland are seeking a
highly motivated individual to participate in a joint interdisciplinary
research project investigating Influenza A and SARS-CoV virus-host
protein-protein interactions and structures. A position at the Post-Doctoral
level is available, to be fill as soon as possible. Competitive applicants
should have demonstrated scientific productivity and innovation at the
graduate level, and possess a Ph.D., M.D., or similar degree. The successful
applicant will have previous experience in all aspects of macromolecular
crystallography, as well as molecular biology, protein expression and
purification. They will interact with our groups to determine the crystal
structures of virus-host protein complexes important in dictating host
tropism. Salary and benefits are competitive, and funding is available be
for up to 2 years.

The Hauptman-Woodward Medical Research Institute (HWI) is a private,
not-for-profit organization studying the structures and functions of
macromolecules of biomedical interest. HWI houses the Department of
Structural Biology of the State University of New York at Buffalo's School
of Medicine and Biomedical Sciences. HWI is part of the Buffalo-Niagara
Medical Campus, a consortium of research, clinical, and educational
institutions founded to cultivate a world-class medical campus in
state-of-the art facilities in downtown Buffalo, NY, USA.

To apply for a post-doctoral position, please send your CV and the names of
three references to Drs. Schultz (schu...@hwi.buffalo.edu) and Umland
(uml...@hwi.buffalo.edu). Please visit the web site for the Laboratory for
the Study of Infectious Diseases (LSID) for additional information:
http://labs.hwi.buffalo.edu/lsid
 
The Hauptman-Woodward Institute is an Equal Opportunity Employer

[ccp4bb] Post-doc position available at Umeå University, Sweden

[Elisabeth Sauer-Eiksson]

A postdoctoral position is available for an experienced molecular
biologist/macromolecular crystallographer in the laboratory of Erik
Johansson and Elisabeth Sauer-Eriksson at Umeå University. The project
involves structure-function studies of DNA polymerase epsilon.

For information and application instructions, please visit

http://www8.umu.se/umu/aktuellt/arkiv/lediga_tjanster/223-2185-2188-09.html

or contact erik.johans...@medchem.umu.se or
elisabeth.sauer-eriks...@chem.umu.se


Your complete application, marked with appropriate reference no, should be
sent to me...@diariet.umu.se (state the reference number as subject) or to
the Registrar, Umeå University, SE-901 87 Umeå, Sweden to arrive September
30, 2009 at the latest.

[ccp4bb] post-doc position at University of Texas Medical Branch

[Kay Choi]

A post-doctoral position is available in my laboratory at University of Texas 
Medical Branch (UTMB) at Galveston to study the structure and mechanism of 
virus infection.  We use a combination of cryo-electron microscopy, X-ray 
crystallography, protein chemistry, and bioinformatics to determine the 
structures of viruses and viral replication machinery, and to develop antiviral 
therapeutics.   Individuals trained in structural biology (i.e., X-ray 
crystallography or cryo-electron microscopy) are encouraged to apply.  

The cryo-electron microscopy facility includes two JOEL 200 keV cryo-electron 
microscopes (a JEM2200FS equipped with an in-column energy filter and 
JEM2100), a 100 keV JEM 1010, and FEI vitrobot.  The JEM 2200FS is located 
in a biosafety level 3 environment to facilitate imaging of infectious agents.  
The X-ray crystallography resources include two X-ray area detector systems, 
a Phoenix crystallization robot, a Minstrel crystal imaging robot, and an 
Alchemist liquid handling robot. 
  
Interested parties should send a CV and a list of 2-3 references to Dr. Kay 
Choi at kay.c...@utmb.edu.

[ccp4bb] Post doc position at University of Alabama at Birmingham

[Heidi Erlandsen]

A Postdoctoral Position is available immediately in the laboratory of  
Heidi Erlandsen at the Institute of Oral Health Research, School of  
Dentistry, University of Alabama at Birmingham, Birmingham, USA. The  
position involves structural and biophysical characterization of the  
interactions of the extracellular growth factor pleiotrophin and its  
receptor protein tyrosine phosphatase beta/zeta.


Experience with cloning, protein expression and purification methods,  
characterization of purified proteins by biophysical techniques and  
protein crystallography is a benefit but not a must. The successful  
applicant must be a US citizen or green card holder due to the nature  
of the funding for the position.


Please send CV, including a description of your experience, a list of  
publications, and names and email addresses of three references to  
herla...@uab.edu

[ccp4bb] post-doc position available

[R. J. Lewis]

dear BBers

there is a post-doc position available in my lab, funded
by the BBSRC for 3 years in the first instance, to study
the biosynthesis of the cell wall in the model bacterium,
Bacillus subtilis. the cell wall, apart from being the
target of penicillin and vancomycin, defines the shape
of the bacterial cell and provides it with a protective
outer layer. there are a host of proteins involved in
the formation of the wall, some - but not all - of which
are membrane proteins. consequently, there is an
opportunity in newcastle for a talented and dedicated
post-doc with demonstrable previous experience of the
structural biology of membrane proteins. further
particulars of this post can be found on newcastle's
vacancies website: http://www.ncl.ac.uk/vacancies/jobs/
with reference code A397R (ICAMB). please apply for
the post by following the instructions on the website,
the closing date for which is 25th may 2009.

please also note that in addition to the post in my lab,
there is a second post available, funded on the same
grant, in the lab of richard daniel for someone with
a more biological focus. applicants to me should
specify that they are applying for 'post 2'.

cheers


rick

--
R. J. Lewis
Professor of Structural Biology
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences   Tel: +44 (0)191 222 5482
University of Newcastle   Fax: +44 (0)191 222 7424
Newcastle upon Tyne, NE2 4HH, UKEmail: r.le...@ncl.ac.uk

[ccp4bb] Post-doc position available at Umeå University, Sweden

[Elisabeth Sauer-Eriksson]

A postdoctoral position is available for an experienced molecular 
biologist/macromolecular crystallographer in the laboratory of Elisabeth 
Sauer-Eriksson at Umeå University. The project involves 
structure-function studies of proteins and protein complexes involved in 
bacteria host cell interactions.


The application should be available to us before the 13th of March.

For information and application instructions, please visit

http://www8.umu.se/umu/aktuellt/arkiv/lediga_tjanster/315,313-39-48-09.html

or contact elisabeth.sauer-eriks...@chem.umu.se

--
Elisabeth Sauer-Eriksson
Professor
Department of Chemistry, KBC
University of Umeå
SE 90187 Umeå
Sweden

Work Ph: +46-90-7865923
Home Ph: +46-90-140602
Mobile Ph: +46-70-6335320
Telefax: +46-90-7865944
E-mail: elisabeth.sauer-eriks...@chem.umu.se
Homepage: http://www.chemistry.umu.se 

[ccp4bb] Post-doc position available

[Van Den Berg, Bert]

A postdoctoral position is available in the laboratory of Bert van den Berg at 
UMass Medical School, Worcester (MA), to work on a NIH-funded project 
investigating the mechanism by which hydrophobic molecules, such as toxic 
xenobiotics, cross the bacterial outer membrane. The focus of the project will 
be on establishing in vivo transport assays for (mono) aromatic hydrocarbons, 
and the purification, crystallization and structure determination of FadL 
homologues from biodegrading bacteria. In addition, channel-substrate complexes 
and site-directed mutants of the toluene channels TodX and TbuX will be 
subjected to structural studies. For more information please see Hearn et al., 
Nature 1 Feb 2009, and Hearn et al., PNAS 105, 8601-8606 (2008), or contact me 
directly.
 
We are looking for a dedicated and enthusiastic person with a strong background 
in molecular biology. Experience with cloning in Pseudomonas species would be 
ideal. Experience in membrane protein biochemistry and X-ray crystallography 
would be advantageous, but is not required. Please send applications and the 
names of two or three references to: bert.vandenb...@umassmed.edu.
 
Bert van den Berg
University of Massachusetts Medical School
Program in Molecular Medicine
Biotech II, 373 Plantation Street, Suite 115
Worcester MA 01605
Phone: 508 856 1201 (office); 508 856 1211 (lab)
e-mail: bert.vandenb...@umassmed.edu
http://www.umassmed.edu/pmm/faculty/vandenberg.cfm



From: CCP4 bulletin board on behalf of Peer Mittl
Sent: Tue 2/24/2009 7:26 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Open Post-Doc and technician positions



Applications are invited for four positions at various levels at the
University of Zürich (Switzerland). Currently there are four vacant
positions at the postdoctoral and research assistant levels (2 Post-Docs
and 2 research assistants) in the lab of Prof. Markus Grütter in the
Department of Biochemistry. We are focusing on the investigation of the
structure/function relationship of proteins involved in apoptosis,
innate immunity and trans-membrane signaling (PNAS (2008) 105:20251,
Structure (2008) 16:1443, Structure (2007) 15:625, PLoS Biol (2007) 5:e7).

We seek enthusiastic team players with experience in at least one of the
following disciplines: protein X-ray crystallography, protein expression
and purification, and eukaryotic expression systems. Experiences in
membrane protein biochemistry will be an advantage. Good knowledge of
English is mandatory. Candidates applying for the Post-Doc position
should hold a PhD in a life science-related subject. All positions are
time limited for three years. Salary will be according to the
regulations of the Swiss National Science Foundation scheme.

Please submit your electronic application including a CV, a list of
publications (for the Post-Doc positions) and the names of two to three
referees to Mrs. Salome Rittmeyer at the following address:
secgruet...@bioc.uzh.ch

Best regards,
Peer Mittl

[ccp4bb] post doc position Genome Institute of Singapore

[Prasanna Ratnakar KOLATKAR]

Dear all

 

There is at least 1 post doctoral position available at the Genome
Institute of Singapore in the lab of Dr Prasanna R Kolatkar. We are
working primarily with transcription factors related to stem cell and
developmental biology.  Although the attached advertisement is primarily
for a computational position, we will also consider people from
molecular biology/biochemistry background.   The contact email given in
the attached document is [EMAIL PROTECTED] but I would also
be happy to discuss and elaborate on any specifics regarding the science
if you like.

 

Prasanna R Kolatkar

Group Leader

Genome Institute of Singapore

[EMAIL PROTECTED] 

 

 



GIS_cryst_postdoc.doc
Description: GIS_cryst_postdoc.doc

[ccp4bb] post doc position at Diamond

[Brandao-Neto, J (Jose)]

 Diamond Light Source is the new UK synchrotron facility, located 
on the Harwell Science and Innovation Campus in South Oxfordshire.

 We are looking to appoint a Post Doctoral Research Assistant to 
support macromolecular crystallography and soft condensed matter 
scientists targeting the development of rational methods for improving 
results in the preparation of macromolecular crystallography samples. 

 The successful candidate will participate in the commissioning of 
the I04-1 beamline, targeting ligand-binding macromolecular 
crystallography experiments. A major aspect of the project is to apply 
nanotemplate crystallisation methods developed recently to study 
the practical implementation of such methods in a protein
crystallisation 
pipeline.

 We offer a competitive salary (dependant upon skills, qualifications
and experience), comprehensive benefits, an index-linked pension
scheme and flexible working hours.

 For further information visit:
http://www.diamond.ac.uk/Jobs/CurrentVacancies/Scientific/DIA0449.htm

 Application deadline: 19th September 2008 

Regards,
Jose Brandao
 
 

Systems Biology Talks at Diamond (SR User Meeting 2007)
http://systemsbiology07.wordpress.com/

Jose Ribeiro Brandao-Neto, MPhil
Beamline Scientist - I04-1
Macromolecular Crystallography Group
 
Diamond Light Source Ltd
Diamond House DR1.78
Harwell Science and Innovation Campus
RAL, Chilton, Didcot
Oxfordshire
OX11 0DE
United Kingdom
 
tel: +44 (0)1235 778506
 +44 (0)1235 778000
fax: +44 (0)1235 778448
 
[EMAIL PROTECTED]
http://www.diamond.ac.uk  
 
This e-mail and any attachments may contain 
confidential, copyright and or privileged material, and are for the use of the 
intended addressee only. If you are not the intended addressee or an authorised 
recipient of the addressee please notify us of receipt by returning the e-mail 
and do not use, copy, retain, distribute or disclose the information in or 
attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
 

[ccp4bb] POST DOC position available at MRC France (BM14 at the ESRF)

[Martin A. Walsh]

Dear all we have an opening for a post-doc at BM14 for 1 year duration. A
summary is given below but please don't hesistate to contact me if you would
like more details  (please direct inquiries to me from the 18th august
onwards as I'm on holidays from tomorrow)

 

 

OVERVIEW:

Beamline 14 (BM14) is a bending magnet beamline at the ESRF dedicated to
macromolecular crystallography and is one of the premier MAD beam lines in
Europe. The beam line is funded as a joint collaboration by the UK Research
Councils (MRC & BBSRC) and the EMBL outstation in Grenoble. In addition to
fostering the use of anomalous phasing methods, for in particular UK and
EMBL member state groups, the beamline has an active in-house structural
biology research group coupled to a programme of beamline directed
developments, in collaboration with groups at the polygone scientique
campus, that provides state of the art facilities for the determination of
protein structures.

 

==

POST-DOCTORAL OPPORTUNITY AT BM14

==   

Contract duration: 1 year

Closing date: 5th September 2008

 

Structural biology research at BM14 is focused on understanding the
molecular basis for adherence in the human pathogen Streptococcus
pneumoniae.We are looking for a highly motivated crystallographer and/or
molecular biologist to contribute to this research program. The successful
candidate would also be expected to drive and contribute to beamline
developments through a full hands-on approach as well as participate to the
BM14 user program.

 

REQUIREMENTS:

 Applicants should have a PhD in a relevant field.  We are searching for a
person with excellent team and communication skills. A proven track record
of macromolecular structure determination; experience in molecular biology,
protein purification and crystallization are desirable. 

The position would suit a highly motivated and energetic individual who is
keen to work in a multidisciplinary environment geared towards structural
biology research. 

 

Applications should include a detailed CV, covering letter and contact
details of three referees to Martin Walsh ([EMAIL PROTECTED], please include
''post doc vacancy in the email subject header). Informal inquiries and
further details about the post can also be directed to Martin Walsh either
by telephone or email ([EMAIL PROTECTED], tel: +33-4-38 88 19 69)

 

 

 

 

-

Martin Walsh,

MRC Group Leader and BM14 Responsible

Medical Research Council (MRC) France,

CRG BM14,

c/o ESRF,

6, rue Jules Horowitz,

B.P. 220

38043 Grenoble CEDEX

France

Tel:   +33 4 38.88.19.69

Fax:  +33 4 76.88.23.80

email1:   [EMAIL PROTECTED]

email2:   [EMAIL PROTECTED]

 

 

 

[ccp4bb] post-doc position available at University of Texas Medical Branch

[Kay Choi]

A post-doctoral position is available in Dr. Choi laboratory at University 
of Texas Medical Branch (UTMB) at Galveston to study the structure and 
mechanism of virus infection.  We use a combination of cryo-electron 
microscopy, X-ray crystallography, protein chemistry, and bioinformatics 
to determine the structures of viruses and viral replication machinery, 
and to develop antiviral therapeutics.   Individuals trained in structural 
biology (i.e., X-ray crystallography or cryo-electron microscopy) are 
encouraged to apply.  

The cryo-electron microscopy facility includes two JOEL 200 keV cryo-
electron microscopes (a JEM2200FS equipped with an in-column energy filter 
and JEM2100), a 100 keV JEM 1010, and FEI vitrobot.  The JEM 2200FS is 
located in a biosafety level 3 environment to facilitate imaging of 
infectious agents.  The X-ray crystallography resources include two X-ray 
area detector systems, a Phoenix crystallization robot, a Minstrel crystal 
imaging robot, and an Alchemist liquid handling robot. 
  
Interested parties should send a CV and a list of 2-3 references to Dr. 
Kyung (Kay) Choi at 301 University Blvd, 6.614 Basic Science Building, 
Galveston, Texas 77555-0647, or via e-mail at [EMAIL PROTECTED]

[ccp4bb] Post-doc position

[Morais, Marc C.]

A post-doctoral position is available in the Morais laboratory at the 
University of Texas Medical Branch (UTMB) in Galveston, TX.  Our laboratory 
uses a combination of X-ray crystallography, cryo-electron microscopy, 
cryo-electron tomography, protein chemistry, and bioinformatics to study the 
structure and assembly of viruses and other large macromolecular complexes.  
Individuals trained in any aspect of structural biology are encouraged to 
apply, especially those with  experience in cryo-electron tomography.  We also 
encourage applications from candidates with experience in virus growth and 
purification who want to learn structural biology  techniques.

X-ray crystallography resources at UTMB include two X-ray area detector 
systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and 
an Alchemist liquid handling robot.  Additionally, as a member of the  Gulf 
Coast Protein Crystallography Consortium, we have ready access  to the protein 
crystallography beam line at the CAMD synchrotron in Baton Rouge, LA.  The 
cryo-electron microscopy facility at UTMB has three JEOL electron microscopes: 
a JEM2200FS equipped with an in-column energy filter, a JEM2100, and a JEM 
1010.  The facility is unique in that infectious agents can be imaged on the 
JEM2200FS under BSL-3 conditions.  Additionally, the center is also equipped 
with an FEI vitrobot to facilitate sample freezing.

Interested parties should send a CV and a list of 2-3 references to Dr. Marc 
Morais at 301 University Blvd, 6.614B Basic Science Building, Galveston, Texas 
77555-0647, or via e-mail at [EMAIL PROTECTED]

[ccp4bb] Post doc position at Sussex University

[Darren Thompson]

Postdoctoral Research Position

MECHANISMS OF DNA DOUBLE-STRAND BREAK REPAIR

Applicants are invited to apply for a postdoctoral fellowship in the area 
of double-strand break repair in prokaryotic cells. Most bacteria, in 
common with eukaryotes, maintain a conserved non homologous end-joining 
(NHEJ) repair pathway required to repair DNA double strand breaks. The aim 
of this project is to study the function of this NHEJ complex in DNA break 
repair processes in bacteria. In particular, we would like to address the 
biochemical and cellular mechanisms of this repair system.


Applicants must have extensive experience in using biochemical/structural 
and molecular biology techniques to study DNA metabolic enzymes. Experience 
in studying biochemical and structural aspects of DNA repair proteins would 
be particularly desirable but other applicants with relevant experience 
will also be considered.


The Genome Damage and Stability Centre is an internationally renowned 
Institute carrying out research on the response of cells to DNA damage, 
genome instability and its relationship to human disease. We provide a 
stimulating and supportive environment and our expertise covers a range of 
experimental systems. Further information about our research can be 
obtained from our website at http://www.sussex.ac.uk/gdsc/


See relevant references:
Weller et al. (2002) Science 297,1686-1689.
Della et al.   (2004) Science 306, 683-685.
Pitcher et al. (2007) Ann. Rev. Microbiol. 61, 258-282.
Pitcher et al. (2007) DNA Repair 6, 1271-1276.
Brissett et al. (2007) Science 318, 456-459.

The post is initially for 18 months with the prospect of extension for a 
further period.


The position is available from May 1st, 2008.

Applications
Informal enquiries to: Dr Aidan Doherty (E-mail:[EMAIL PROTECTED]; Tel: 
01273 877500). Applications, including a CV with contact details of two 
referees, should be sent  to: [EMAIL PROTECTED]


Closing date for applications: 14th of April, 2008.


The University of Sussex is committed to equality of opportunity

Re: [ccp4bb] Post-doc position at the IBS, Grenoble, France

[bas]

- Original Message -
From: Dominique BOURGEOIS
To: CCP4BB@JISCMAIL.AC.UK
Sent: Friday, January 04, 2008 4:18 PM
Subject: [ccp4bb] Post-doc position at the IBS, Grenoble, France

Kinetic protein crystallography of fluorescent proteins.
[...]
Candidates should have a strong expertise in crystallography, biochemistry
and UV-visible spectroscopy. A general background in bio-physics and an
interest for imaging applications is recommended to conduct this highly
pluri-disciplinary project. Administrative rules state that candidates
should preferably be less than 30 years and have defended their phD in the
last 2 years. The monthly gross salary will amount to ~2750 €.




It would seem that these "administrative rules" (truly fascinating
euphemism by the way) are actually quite illegal in most civilised
countries.

For instance, the European parliament as early as 2000 accepted a
directive which explicitly puts age discrimination on a par with
discrimination based on gender, race, political/religious beliefs and
sexual orientation. Since, this directive has been duly implemented in
national law, e.g. in Britain
(http://www.direct.gov.uk/en/Employment/Employees/DiscriminationAtWork/DG_1
0026429) and France (http://www.actuchomage.org/modules.php?
op=modload&name=PagEd&file=index&topic_id=5&page_id=150).

I am somewhat surprised (and, frankly, disappointed) to see that
advertisements like the one above nevertheless continue to be commonplace
in the scientific world.

Is anyone aware if research positions and grants indeed constitute legally
sound exceptions to the aforementioned anti age discrimination laws? Or do
scientists collectively assume that social legislation doesn't apply to
our community, accustomed we are to e.g. shady postdoctoral grants with
little or no social security?

Sebastiaan Werten.

[ccp4bb] Post-doc position at the IBS, Grenoble, France

[Dominique BOURGEOIS]

Kinetic
protein crystallography of fluorescent proteins.
A
two-year post-doctoral fellowship is available in the “kinetic protein
crystallography” team of the Institute for Structural Biology (IBS), Grenoble, France
(http://www.ibs.fr/content/ibs_eng/presentation/lab/lccp/cinetique/).
The project is financed by the French "Agence Nationale de la
Recherche" (ANR). It consists in studying the fluorescence
mechanisms of fluorescent proteins (FP’s) from the Green Fluorescent
Protein
(GFP) family, by combining X-ray crystallography with UV-visible and
Raman microspectrophotometry.
Fluorescent proteins are typically used as markers in fluorescence cell
imaging. Recently discovered FP’s undergo multiple photo-switching
processes,
which make them invaluable tools to study cell dynamics and develop
super-resolution imaging methods. Such proteins also offer fascinating
perspectives for biotechnological applications such as the development
of
high-capacity storage devices. The work aims at improving fundamental
knowledge
of the photophysics of FP’s, and at rationally designing new FP’s with
enhanced
properties. It will involve both local and international collaborations
with
teams specialized in molecular biology, ab-initio
quantum calculations and cell imaging. The project will be performed in
the
context of a very tight collaboration with the ESRF synchrotron and
will make
intense usage of the Cryobench, a laboratory dedicated to in
crystallo spectroscopic techniques (http://www.esrf.eu/UsersAndScience/Experiments/MX/Cryobench/).
Photo-switching will be triggered in FP crystals following the methods
of
kinetic crystallography, so as to determine the induced conformational
changes
along the switching pathway.
Candidates
should have a strong expertise in crystallography,
biochemistry and UV-visible spectroscopy. A general background in
bio-physics
and an interest for imaging applications is recommended to conduct this
highly
pluri-disciplinary project. Administrative rules state that candidates
should preferably
be less than 30 years and have defended their phD in the last 2 years.
The
monthly gross salary will amount to ~2750 €. 
Applications should be sent to Dominique Bourgeois
([EMAIL PROTECTED]).
-- 
Dominique BOURGEOIS


 /\ Dominique Bourgeois/\/\
/  \  LCCP IBS/\/ /\
 /\/\ UMR 5075   /  \/  \   
/  \ \ 41 Rue Jules Horowitz \   \  
\ \ 38027 GRENOBLE Cedex 1\   \   
 \ \   FRANCE  \   \

** phone:   (+33) (0)4 38 78 96 44 **
** fax: (+33) (0)4 38 78 51 22 **
** e-mail: [EMAIL PROTECTED] ***

   

[ccp4bb] Post-doc position at Karolinska, Stockholm

[Marjolein Thunnissen]

Now the proper version, sorry for that!

Post-Doctoral position available Karolinska Insitute, Sweden
 
A post-doctoral position is available at the Department of Medical
Biochemistry and Biophysics (MBB), Karolinska Institute, Stockholm. The
project deals primarily with overexpression, purification and
crystallisation of four receptors involved in inflammation, all of which are
key targets for drug development. A prospective candidate should have a
Ph.D. and should have a strong background in crystallisation, protein
purification and expression especially of membrane proteins. Subsequent
structure determination will be in collaboration with the group of Dr.
Marjolein Thunnissen, Lund University. MBB is one of the largest departments
at Karolinska Institutet equipped with a range of state-of-the-art
technologies in basic research, in particular proteomics, structure biology,
imaging, and animal models. It hosts world leading groups in areas such as
molecular neurobiology, matrix biology, vascular biology, redox regulation,
and lipid mediators of inflammation, which together create a vibrant
research environment.
 
 
Interested candidates should send a CV and letters of reference by either
email to [EMAIL PROTECTED] or by normal post Prof J. Haeggstrom, MBB,
KI, S-171 77 Stockholm, Sweden.

[ccp4bb] Post-doc position at Karolinska, Stockholm

[Marjolein Thunnissen]

Post-Doctoral position available Karolinska Insitute, Sweden
 
A post-doctoral position is available at the Department of  Molecular
Biochemistry and Biophysics, Karolinska Institute, Stockholm. The project
deals with overexpression, purification and crystallisation of a receptor
involved in inflammation. A prospective candidate should have a Ph.D. and
should have a good background in crystallisation, protein purification and
expression especially of membrane proteins. Subsequent structure
determination will be in collaboration with the group of Dr. Thunnissen,
Lund University. the department of MBB is xxx
 
 
Interested candidates should send a CV and letters of reference by either
email to [EMAIL PROTECTED] or by normal post Prof J. Haeggstrom,
MBB, KI, Postbox  Stockholm, Sweden

[ccp4bb] post-doc position in Gif sur Yvette (France)

[Marcel Knossow]

STRUCTURAL BIOCHEMISTRY OF THE INTERACTION OF KINESINS WITH TUBULIN

	A post-doctoral fellowship is available at the Laboratoire 
d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Gif-sur-Yvette, 
France. The contract will be initially for a period of one year.
	Our group works on the structural study of the regulation of 
microtubule assembly. This project deals with kinesins that catalyse 
microtubule disassembly. In this project, we will study the interaction 
of these kinesisns with tubulin by biophysical and biochemical methods 
in solution and characterize the resulting complexes by X-ray 
crystallography and in collaboration with electron microscopists.
	The lab has state of the art equipment for protein purification and 
characterization. Crystallization robotics and X-ray diffraction 
equipment are also available in-house (see 
http://www.lebs.cnrs-gif.fr/home.html). We are located in a 
multidisciplinary life sciences campus, 40 minutes by direct train from 
the centre of Paris with a regular access to synchrotron sources 
including the closeby french synchrotron SOLEIL.
Applicants should hold a Ph. D., have experience in biochemistry 
(cloning, protein expression, purification and characterization) and an 
interest in structural studies. Experience in protein crystallization 
and crystallography would be an advantage but motivated biochemists – 
molecular biologists will be trained in these techniques.
To apply, please send a CV, a short summary of your research experience 
and the names and contact information of two referees by e-mail to Dr. 
Marcel Knossow ([EMAIL PROTECTED]). For details on the group 
please see our web page 
(http://www.lebs.cnrs-gif.fr/knossow/knossowang.html).



 

[ccp4bb] Post-doc position available

[Ines Gallay]

*Post-doc position available, from Jan 2008*

*Title : *Crystallography of /B. subtilis/ ribonucleases
*Group :* Ciarán Condon, under supervision of Inés Li de la Sierra-Gallay.
*Address :* CNRS UPR9073/IFR550, Institut de Biologie Physico-Chimique, 
13 rue Pierre et Marie Curie, 75005 Paris.
*Contact :* [EMAIL PROTECTED] _ or 
[EMAIL PROTECTED] _

*Web-site :* http://www.ibpc.fr/UPR9073/condon/index_en.html
*Financed by :* Agence Nationale de la Recherche (ANR) for 2 years
*Description :* It has recently become clear/ /that the pathways of RNA 
maturation and decay in the Gram-positive bacterium /B. subtilis/ are 
very different from those of the generally accepted bacterial paradigm, 
the Gram-negative /E. coli/. As such, /B. subtilis/ is a rich source of 
new bacterial ribonucleases. We have recently solved the crystal 
structure of one of these : RNase Z, both free and in complex with its 
tRNA product (Li de la Sierra-Gallay et al., 2006; Li de la 
Sierra-Gallay et al., 2005). We now hope to persue this study with other 
recently identified /B. subtilis/ RNases and their substrates. Among 
these are the 5S rRNA maturase RNase M5, the 23S rRNA maturase YazC, and 
the 3’ to 5’ exoribonuclease KapD. We would like to solve the crystal 
structures of RNase Z in complex with its precursor (rather than 
product) species and that of the endo/exoribonuclease RNase J1 in 
complex with RNA.
Candidates should have some experience in protein purification, 
crystallography and structure resolution.

*References :*
Li de la Sierra-Gallay, I., Mathy, N., Pellegrini, O. and Condon, C. 
(2006) Structure of the ubiquitous 3' processing enzyme RNase Z bound to 
transfer RNA. /Nat Struct Mol Biol/, *13*, 376-377.
Li de la Sierra-Gallay, I., Pellegrini, O. and Condon, C. (2005) 
Structural basis for substrate binding, cleavage and allostery in the 
tRNA maturase RNase Z. /Nature/, *433*, 657-661.



--
Ines Gallay
CNRS FRC550
Institut de Biologie Physico-Chimique
13 rue Pierre et Marie Curie
75005 Paris
FRANCE
e-mail: [EMAIL PROTECTED]

[ccp4bb] post-doc position in Gif-sur-Yvette (France)

[Marcel Knossow]

STRUCTURAL BIOCHEMISTRY OF THE INTERACTION OF THE NEURONAL PROTEIN TAU 
WITH TUBULIN


	A post-doctoral fellowship is available immediately at the Laboratoire 
d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Gif-sur-Yvette, 
France. The contract will be initially for a period of one year.
	Our group works on structural aspects of the regulation of microtubule 
assembly. This project deals with Tau family proteins. These proteins 
favor microtubule assembly but, when abnormally phophorylated, they 
aggregate. They are associated with the symptoms of Alzheimer disease; 
in addition, some familial forms of dementia are correlated with 
mutations in Tau. In a joint project with an NMR group (for recent work 
on the interaction of Tau with microtubules see Sillen et al. (2007) 
Biochemistry 46, 3055), we will study the interaction of Tau with 
tubulin by biophysical and biochemical methods in solution and 
characterize by X-ray crystallography the complexes formed.
	The lab has state of the art equipment for protein purification and 
characterization. Crystallization robotics and X-ray diffraction 
equipment are also available in-house (see 
http://www.lebs.cnrs-gif.fr/home.html). We are located in a 
multidisciplinary life sciences campus, 40 minutes by direct train from 
the centre of Paris with a regular access to synchrotron sources 
including the closeby french synchrotron SOLEIL.
Applicants should hold a Ph. D., have experience in biochemistry 
(cloning, protein expression, purification and characterization) and an 
interest in structural studies. Experience in protein crystallization 
and crystallography would be an advantage but motivated biochemists – 
molecular biologists will be trained in these techniques.
To apply, please send a CV, a short summary of your research experience 
and the names and contact information of two referees by e-mail to Dr. 
Marcel Knossow ([EMAIL PROTECTED]). For details on the group 
please see our web page 
(http://www.lebs.cnrs-gif.fr/knossow/knossowang.html).