Re: [ccp4bb] Protein fold and the moonlighting function

[Emmanuel Saridakis]

I believe this is more than a fluke. It looks to me like a very powerful 
evolutionary tool which may have rendered the early stages in the evolution of 
life less improbable.
Best wishes,
Emmanuel Saridakis


- Original Message -
From: "Peter Stogios" 
To: "CCP4BB" 
Sent: Monday, 3 February, 2020 02:18:45
Subject: Re: [ccp4bb] Protein fold and the moonlighting function

I think you’re asking if two proteins with the same fold can have different 
activities.

As was previously mentioned, this is quite common.  The best characterized 
example is the TIM barrel fold - such proteins can be isomerases, transferases, 
hydrolases, lyases, or oxidoreductases, to name a few...



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Re: [ccp4bb] Protein fold and the moonlighting function

[Peter Stogios]

I think you’re asking if two proteins with the same fold can have different 
activities.

As was previously mentioned, this is quite common.  The best characterized 
example is the TIM barrel fold - such proteins can be isomerases, transferases, 
hydrolases, lyases, or oxidoreductases, to name a few...



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Re: [ccp4bb] Protein fold and the moonlighting function

[Jonathan Cooper]

 Hello, 
Re: "I think you’re asking about 2 proteins with a similar fold having similar 
but not exactly the same functions - yes, that does occur."
Indeed, I suspect it is very common, if not the norm. OK, so I now 
gather/remember moonlighting proteins are ones with more than one function - 
thank you for the link to the very interesting database. Is perhaps the 
questioner asking if homologues of a moonlighting protein also have similar 
moonlighting functions? If so, I'm out of my depth on that one.
Best wishes, Jon Cooper.On Sunday, 2 February 2020, 18:22:10 GMT, Jeffery, 
Constance J  wrote:  
 
 Hi Rajnandani,
I’m happy to help you with questions about moonlighting proteins.  My lab 
created the MoonProt Database (moonlightingproteins.org).  
I think you’re asking about 2 proteins with a similar fold having similar but 
not exactly the same functions - yes, that does occur.
Best regards,Connie Jeffery


On Feb 2, 2020, at 4:28 AM, Rajnandani Kashyap  
wrote:
Dear All
I am curious to know about the promiscuous activity of a protein based on their 
fold. Can a protein having same fold also have same function (say not 100% but 
some activity) as the homologous structure. 
Please also let me know few relevant PDB structures where such kind of activity 
is shown promising. 


Regards
Rajnandani Kashyap
PhD Student


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Re: [ccp4bb] Protein fold and the moonlighting function

[Jeffery, Constance J]

Hi Rajnandani,

I’m happy to help you with questions about moonlighting proteins.  My lab 
created the MoonProt Database 
(moonlightingproteins.org).

I think you’re asking about 2 proteins with a similar fold having similar but 
not exactly the same functions - yes, that does occur.

Best regards,
Connie Jeffery

On Feb 2, 2020, at 4:28 AM, Rajnandani Kashyap 
mailto:kashyap.rajnand...@gmail.com>> wrote:

Dear All

I am curious to know about the promiscuous activity of a protein based on their 
fold. Can a protein having same fold also have same function (say not 100% but 
some activity) as the homologous structure.

Please also let me know few relevant PDB structures where such kind of activity 
is shown promising.


Regards

Rajnandani Kashyap
PhD Student




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Re: [ccp4bb] Protein fold and the moonlighting function

[00000c2488af9525-dmarc-request]

Can you possibly expand a bit on exactly what you are asking?Jon CooperOn 2 Feb 2020 09:28, Rajnandani Kashyap  wrote:Dear AllI am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity) as the homologous structure. Please also let me know few relevant PDB structures where such kind of activity is shown promising. RegardsRajnandani KashyapPhD Student


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On 2 Feb 2020 09:28, Rajnandani Kashyap  wrote:Dear AllI am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity) as the homologous structure. Please also let me know few relevant PDB structures where such kind of activity is shown promising. RegardsRajnandani KashyapPhD Student


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On 2 Feb 2020 09:28, Rajnandani Kashyap  wrote:Dear AllI am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity) as the homologous structure. Please also let me know few relevant PDB structures where such kind of activity is shown promising. RegardsRajnandani KashyapPhD Student


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[ccp4bb] Protein fold and the moonlighting function

[Rajnandani Kashyap]

Dear All

I am curious to know about the promiscuous activity of a protein based on
their fold. Can a protein having same fold also have same function (say not
100% but some activity) as the homologous structure.

Please also let me know few relevant PDB structures where such kind of
activity is shown promising.


Regards

Rajnandani Kashyap
PhD Student



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