Re: FDA information regarding meat vs. meat meal/was interesting info on the felidae website..link correction

[gg]

Hi Phaewryn,

Whoops, I should have checked the link!  Here is the updated link:
http://www.fda.gov/cvm/petlabel.htm


Kind regards,

Glenda

FeLV/FIV cats and a bunch of other stuff:
http://community.webshots.com/user/sicky_icicle

  - Original Message - 
  From: gg 
  To: felvtalk@felineleukemia.org 
  Sent: Saturday, March 17, 2007 10:18 PM
  Subject: FDA information regarding meat vs. meat meal/was interesting info on 
the felidae website..


  Hi Phaewryn,

  Do you know where you learned this? When I was investigating Pet Food labels 
(since 99), this is the information that I found in 2000 and haven't found any 
reliable source that disagrees.

  <http://www.fda.gov/cvm/index/fdavet/1998/november.htm#PET>


  INTERPRETING PET FOOD LABELS -- PART 1: GENERAL RULES 
  by David A. Dzanis, D.V.M., Ph.D., DACVN

  ..."For example, one pet food may list "meat" as its first ingredient, and 
"corn" as its second. The manufacturer doesn't hesitate to point out that its 
competitor lists "corn" first ("meat meal" is second), suggesting the 
competitor's product has less animal-source protein than its own. However, meat 
is very high in moisture (approximately 75 percent water). On the other hand, 
water and fat are removed from meat meal, so it is only 10 percent moisture 
(what's left is mostly protein and minerals). If we could compare both products 
on a dry matter basis (mathematically "remove" the water from both 
ingredients), one could see that the second product had more animal-source 
protein from meat meal than the first product had from meat, even though the 
ingredient list suggests otherwise."

  Kind regards,

  Glenda


  FeLV/FIV cats and a bunch of other stuff:
  http://community.webshots.com/user/sicky_icicle

FDA information regarding meat vs. meat meal/was interesting info on the felidae website..

[gg]

Hi Phaewryn,

Do you know where you learned this? When I was investigating Pet Food labels 
(since 99), this is the information that I found in 2000 and haven't found any 
reliable source that disagrees.




INTERPRETING PET FOOD LABELS -- PART 1: GENERAL RULES 
by David A. Dzanis, D.V.M., Ph.D., DACVN

..."For example, one pet food may list "meat" as its first ingredient, and 
"corn" as its second. The manufacturer doesn't hesitate to point out that its 
competitor lists "corn" first ("meat meal" is second), suggesting the 
competitor's product has less animal-source protein than its own. However, meat 
is very high in moisture (approximately 75 percent water). On the other hand, 
water and fat are removed from meat meal, so it is only 10 percent moisture 
(what's left is mostly protein and minerals). If we could compare both products 
on a dry matter basis (mathematically "remove" the water from both 
ingredients), one could see that the second product had more animal-source 
protein from meat meal than the first product had from meat, even though the 
ingredient list suggests otherwise."

Kind regards,

Glenda


FeLV/FIV cats and a bunch of other stuff:
http://community.webshots.com/user/sicky_icicle

Re: Importation of drugs

[gg]

Michelle,I ordered the paper last week, and this 
natural human ifn (Alfaferone) uses several human 
IFN-a subtypes, including IFN-a1, a2, -a8 and -a21It is reminiscent 
of some of the earlier studies on FeLV & FIV that used either a 
natural interferon (was then referred to as a 
'Cantell' type), or a or hybrid containing IFN A/D subtypes in the late 80's, 
early 90's. In one of the papers I ordered (several years ago), there were 2 
cats that seroconverted from both FIV & FeLV. One of the cats had 
nonregenerative anemia and seroconverted after 90 days of alternate-week 
treatment and the other had chronic nonrefractory dermatomycosis and had 
complete resolution of symptoms and later seroconverted to both viruses. If you 
do a search on "Kemron interferon", it may be of interest. PubMed's good, 
too.It certainly, at least in this study, looks 
"promising". and would certainly be cheaper than the Feline Omega for FIV 
& FeLV sanctuaries.GlendaVancouver Cats & 
Gardens:http://community.webshots.com/user/sicky_icicle/0
 
 
 
 
 
In a message dated Tue, 01 Nov 2005 09:08:15 -0800,  
Lernermichelle wrote:
Are you talking about interferon omega, also called Feline 
Interferon or Virbagen Omega? A few of us have imported that, and we have all 
the forms in electronic version, and Nina's vet has put together a packet she 
sends out to anyone interested. Basically, the vet needs to send an application 
to the FDA for special dispensation. The FDA then takes a month or two to 
approve it, sends the approval to the vet, and the vet sends that to Abbey Vet 
in England with the order.Michelle
 
 
 

Re: OT:FIV false positive?

[gg]

Hi MC,
 
Whenever I see something of interest, I use CISTI which 
allows you full access to the "neverending" research on whatever one wishes. The 
study that I recall that I ordered a few years ago that confirmed 
non-aggressive transmission (other than "paw flailing" at their 
feeding station) was this one. Here's the abstract:
 
 
: Vet Rec. 2000 Apr 8;146(15):419-24. Related Articles, Links  

 
Long-term impact on a closed household of pet cats of natural infection 
with feline coronavirus, feline leukaemia virus and feline immunodeficiency 
virus.
 
Addie DD, Dennis JM, Toth S, Callanan JJ, Reid S, Jarrett O.
 
Department of Veterinary Pathology, University of Glasgow Veterinary 
School, Bearsden.
 
A closed household of 26 cats in which feline coronavirus (FCoV), feline 
leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) were endemic was 
observed for 10 years. 
 
Each cat was seropositive for FCoV on at least one occasion and the 
infection was maintained by reinfection. After 10 years, three of six surviving 
cats were still seropositive. 
 
Only one cat, which was also infected with FIV, developed feline infectious 
peritonitis (FIP). Rising anti-FCoV antibody titres did not indicate that the 
cat would develop FIP. 
 
The FeLV infection was self-limiting because all seven of the initially 
viraemic cats died within five years and the remainder were immune. 
 
However, FeLV had the greatest impact on mortality. Nine cats were 
initially FIV-positive and six more cats became infected during the course of 
the study, without evidence of having been bitten. 
 
The FIV infection did not adversely affect the cats' life 
expectancy.
 
PMID: 10811262 [PubMed - indexed for MEDLINE] 
Kind regards,
 
Glenda
 

Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 
 
 
- Original Message - 
From: TenHouseCats <[EMAIL PROTECTED]>
To: 
Sent: Monday, March 28, 2005 4:37 PM
Subject: Re: OT:FIV false positive?
> hideyo, i would be very interested in seeing any info 
showing> non-aggressive contact passing the FIV virus--that goes 
against> everything i have read and if there IS such info, it's important 
that> all of us with positives know! (i tend to suspect it's not 
current> info, but since things change so quickly now that they're 
actually> doing research, i'm open)> > thanks!> 
> MC

Re: OT:FIV false positive?

[gg]

Hi Hideyo,

This particular study was on NATURALLY infected cats (no IP infections -
Yuk)

Kind regards,

Glenda


Our FeLV/FIV kitties & other stuff:
http://community.webshots.com/user/sicky_icicle




- Original Message -
From: Hideyo Yamamoto <[EMAIL PROTECTED]>
To: 
Sent: Monday, March 28, 2005 4:50 PM
Subject: RE: OT:FIV false positive?


I will try to find it - it was an official experimental study done by
someone (whom of course I can't remember)

Additional Info on the Six Stages of FeLV infection

[gg]

Kirk's Current Veterinary Therapy  XIII Small Animal 
PracticeCVT Update: Feline Leukemia Virus pgs 281
Year Published: 2000
 
Dr. Alice M. Wolf, ACVIM, ABVP (Fe)(One of the Internal Medicine 
Consultants on the www.vin.com  
board.)
 
 
PATHOGENESIS OF FELV
 
Following infection, FeLV has a specific pattern or 
replication that affects the results of FeLV testing and the clinical signs that 
may be seen in an individual cat.
 
STAGE I: Days 2 - 4Replication: In local 
lymphoid tissue (retropharyngeal, tonsil, gastrointestinal mucosal).Clinical 
Signs: None to mild viral (fever)FeLV status: All tests negative at this 
timePrognosis: Majority recover
 
STAGE II: Days 1 - 14Replication: Few 
circulating lymphocytes and mononuclear cells (primary Viremia)Clinical 
Signs: None, or mild viral signsFeLV status: Serum ELISA becomes 
positive, PCR may be positive, (IFA, saliva, tears 
negative)Prognosis: Most recover, possible latency (6-30 mo)
 
STAGE III Days 3 - 12Replication: 
Systemic lymphoid centers (germinal centers)Clinical Signs: None, or mild to 
moderate viral signsFeLV status: Serum ELISA positive, PCR positive, 
(IFA, saliva, tears negative) Prognosis: Recovery for many, 
possible future lymphosarcoma
 
STAGE IV Days 7 - 21Replication: Bone 
marrow stem cells, epithelial cellsClinical Signs: Peripheral blood 
alterations, viral signsFeLV status: Serum ELISA, PCR, bone marrow 
IFA positive (peripheral-blood IFA positive or negative, saliva, tears 
negative)Prognosis: Likely to progress to persistent 
infection
 
STAGE V Days 14 - 28Replication: Marrow 
origin, general viremiaClinical Signs: All associated hematologic and 
systemic FeLV signs possibleFeLV status: Serum ELISA, PCR, bone 
marrow, and peripheral-blood IFA positive (saliva, tears 
negative)Prognosis:  Persistent Viremia, recovery from this 
stage of infection is rare
 
STAGE VI Days 28 - ?Replication: Marrow 
Viremia, widespread epithelial and lymphoid replicationClinical Signs: Any 
associated with FeLV
FeLV status: Serum ELISA, PCR, BM and peripheral 
blood IFA, ELISA on saliva and tears may be positive
Prognosis: Long term prognosis is grave, 83% of cats die 
within 3.5 years in multicat households, longevity is increased for single cats 
with good veterinary care.

Re: Intercat by Toray Industries - Intercat IS Virbac's Feline Interferon.....

[gg]

Hi Cherie,
 
Sorry if there was any confusion regarding the links I sent!!
 
The development of interferon was carried out by TORAY INDUSTRIES 
(Japan)The preparation of the active ingredient is done at TORAY 
(Japan)
The active ingredient, i.e. the desalted bulk of interferon, is transported 
from Toray (Japan) to VIRBAC (FRANCE).
It's the same 'stuff' that is being ordered by members on this list.
 
Here is one of the messages from the felvlist archives..(1999).
 
Cheers!
 
Glenda

Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 
Feline interferon
 
Cesar ( [EMAIL PROTECTED] 
)Thu, 28 Oct 1999 12:17:51 -0700 
Hi, Sue and all
The problem we have with interferon (Intron-A) is that once it is 
prepared, it loses part of efficiency quickly (my vet says), therefore, we are 
attempting to verify what type of interferon you use which can be kept during so 
much time, and in spite of the fact Salamanca is a university city, 
unfortunately, there isn't vet school. :((
Concerning the possibility to obtain Intercat in USA or Europe, in the 
web page of Toray laboratory we can read:"Toray Gives Sole Developing and 
Marketing Rights for Intercat in Europe to France-Based Virbac Toray Industries, 
Inc., has announced that it has given rights to develop and market Intercat in 
Europe to Virbac S.A., of France. Intercat is drawing international attention as 
the world's first recombinant feline interferon agent for companion animals. 
Under the arrangement, Virbac will work with Toray in conducting clinical tests 
to acquire approval for Intercat from European authorities. 
Toray foresees considerable demand for Intercat in Europe, where the 
population of domesticated cats totals over 35 million -- almost 5 times the 
number in Japan. 
Headquartered in Nice, Virbac manufactures and markets pharmaceuticals 
for animals worldwide -- the fifth largest supplier in the world of such 
products for small animals. As part of its operations, Virbac is developing 
Leucogen, a recombinant feline leukemia vaccine that is already being marketed 
in Europe, USA and Japan. 
Through Kyoritsu Shoji K.K. (Headquarters: Tokyo; President:Yuriko 
Takai), Toray has been marketing Intercat in Japan since February 1994 
as an antiviral agent effective against the infectious disease commonly known as 
cats' cold, which is caused by feline calicivirus. Development and 
marketing rights for Intercat in the Americas have been given to Schering-Plough 
Corp., of the United States, where the further development of Intercat is 
continuing." 
Well, I haven't found anything about Intercat at Schering-Plough 
laboratory but at Virbac web page WE CAN READ:"Interferon, the first 
veterinary antiviral agent. Developed by the Japanese company TORAY, interferon 
is a natural compound with antiviral properties.Used in Japan for calicivirosis 
in cats and parvovirosis in dogs, interferon has inspired great hopes among 
European veterinarians. 
In 1997, Virbac obtained exclusive rights for the distribution of this 
drug in Europe, and the rights for its application for other therapeutic 
indications." 
http://www.virbac.frWhy vets 
doesn't know this?. I will tell him IMMEDIATELLY!. If I would obtain more 
information, I will post.
GreetingsCesar

Virbagen Feline Omega Interferon Example 6 (no seroconversion)

[gg]

Example 6 
 
A recombinant feline .omega.-interferon preparation (Trade 
Name: INTERCAT) was administered to a 2-year-old crossbred male cat, which was 
observed to have neutropenia due to a feline leukemia virus infection. 
 
On the first day of examination, the cat had a weight of 3.9 
kg and a body temperature of 40.4.degree. C., and lymphatic swelling was 
observed. The cat had an appetite and vigor. Blood test results were as follows: 
PCV 22%, WBC 5,800, neutrophil 696, lymphocyte 4,698, monocyte 116, eosinophil 
290, and thrombocyte 200,000. In the virus test, an FeLV antigen was detected 
and an FIV antibody was not detected. 
 
After 5 days, although appetite and vigor were observed, the 
body temperature was 39.2.degree. C., and blood test results were as follows: 
PCV 22%, WBC 5,800, neutrophil 131, lymphocyte 4,963, monocyte 219, eosinophil 
483, and thrombocyte 200,000. 
 
The INTERCAT was dissolved in a physiological saline 
solution and was subcutaneously injected at a dose of 4 MU/day for six days. The 
dose was 1.03 MU/kg per cat weight. A transfusion (lactate Ringer's 
solution and glucose) was injected by intravenous drip infusion at a dose of 500 
ml/day, and an antibiotic (cephalexin) was intravenously injected at a dose of 
100 mg twice a day. 
 
On the second day after the administration of the INTERCAT, 
the body temperature was 39.5.degree. C., and blood test results were as 
follows: PCV 24%, WBC 4,200, neutrophil 400, lymphocyte 3,400, monocyte 200, 
eosinophil 200, and thrombocyte 200,000. 
 
On the fourth day, the body temperature was 38.7.degree. C., 
and blood test results were as follows: PCV 23%, WBC 5,000, neutrophil 1,150, 
lymphocyte 3,100, monocyte 450, eosinophil 200, and thrombocyte 200,000. On the 
seventh day, the body temperature was 38.9.degree. C., and blood test results 
were as follows: PCV 18%, WBC 6,100, neutrophil 1,769, lymphocyte 3,050, 
monocyte 1,220, eosinophil 61, and thrombocyte 200,000. 
 
In this example, significant recovery of neutrophils 
was not observed, and abatement of fever and improved general condition were 
observed.
 

Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 

Virbagen Feline Omega Interferon Example 5 (no seroconversion)

[gg]

Example 5 A recombinant feline .omega.-interferon 
preparation (Trade Name: INTERCAT) was administered to a 6-month-old crossbred 
female cat, which was observed to have neutropenia due to a feline leukemia 
virus infection. 
On the first day of examination, the cat had a weight of 2.2 
kg and a body temperature of 41.5.degree. C., and a complete loss of appetite, a 
loss of vigor, rhinorrhea, slaver, and dacryorrhea were observed. 
Blood test results were as follows: PCV 32%, WBC 4,400, 
neutrophil 2,885, lymphocyte 961, monocyte 732, eosinophil 0, and thrombocyte 
100,000. In the virus test, an FeLV antigen was detected, an FIV antibody was 
not detected, and a Parvovirus antigen was not detected. The INTERCAT 
was dissolved in a physiological saline solution, and was subcutaneously 
injected at a dose of 3 MU/day for five days. The dose was 1.36 MU/kg per cat 
weight. A transfusion (lactate Ringer's solution and glucose) was injected 
by intravenous drip infusion at a dose of 500 ml/day, and an antibiotic 
(cephalexin) was intravenously injected at a dose of 150 mg twice a day. 
On the fifth day, the cat had a body temperature of 38.9.degree. 
C., had an appetite, and rhinorrhea, slaver, and dacryorrhea were alleviated. 

Blood test results were as follows: 
PCV 26%, WBC 8,500, neutrophil 6,855, lymphocyte 1,020, 
monocyte 425, eosinophil 170, and thrombocyte 200,000. 
On the 13th day, aggravation occurred again. The body 
temperature was 40.2.degree. C., anorexia was observed, and rhinorrhea, 
slaver, and dacryorrhea were aggravated. Blood test results were as follows: 
PCV 28%, WBC 7,000, neutrophil 840, lymphocyte 4,340, monocyte 1,680, eosinophil 
140, and thrombocyte 200,000. The INTERCAT was again subcutaneously 
injected at a dose of 3 MU/day for four days. The transfusion or antibiotic 
was not administered. On the 17th day, the body temperature was 
38.50.degree. C., and appetite and vigor had recovered. Blood test results 
were as follows: PCV 24%, WBC 19,100, neutrophil 10,186, lymphocyte 7,003, 
monocyte 1,782, eosinophil 127, and thrombocyte 200,000.
 
Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle

Virbagen Feline Omega Interferon (FeLV & FIV no longer detectable)

[gg]

The link can be found here: 
 

 
 
Example 4 
 
A recombinant feline o-interferon preparation (Trade Name: INTERCAT) was 
administered to a 5-year-old crossbred female cat (sterilized), which was 
observed to have neutropenia due to a feline leukemia virus infection. 
 
On the first day of examination, the cat had a weight of 3.25 kg and a body 
temperature of 40.7.degree. C., and a complete loss of appetite, a loss of 
vigor, and pneumonia were observed. Blood test results were as follows: PCV 37%, 
WBC 1,100, neutrophil 22, lymphocyte 836, monocyte 132, eosinophil 88, and 
thrombocyte 30,000. In the virus test, both an FeLV antigen and an FIV 
antibody were detected. 
 
The INTERCAT was dissolved in a physiological saline solution, and 
was subcutaneously injected at a dose of 5 MU/day for four days. 
 
The dose was 1.54 MU/kg per cat weight. A transfusion 
(lactate Ringer's solution and glucose) was injected by intravenous drip 
infusion at a dose of 500 ml/day, and an antibiotic (cephalexin) was 
intravenously injected at a dose of 100 mg twice a day. 
 
Blood test results on the third day were as follows: PCV 36%, WBC 8,400, 
neutrophil 3,864, lymphocyte 3,444, monocyte 840, eosinophil 168, and 
thrombocyte 30,000. 
 
On the fifth day, the body temperature had decreased to 38.6.degree. C., 
and the blood examination results were as follows: PCV 32%, WBC 7,300, 
neutrophil 4,088, lymphocyte 2,920, monocyte 292, eosinophil 0, and thrombocyte 
60,000. 
 
On the 10th day, the body temperature was 38.5.degree. C., appetite and 
vigor had recovered, and pneumonia was also cured. The cat had a weight of 3.3 
kg. Blood test results were as follows: PCV 31%, WBC 11,468, neutrophil 7,568, 
lymphocyte 3,325, monocyte 573, eosinophil 0, and thrombocyte 100,000. 
 
On the 18th day, in the virus test, the FeLV antigen was not 
detected, the FIV antibody also was not detected. After one year, both the FeLV 
antigen and the FIV antibody were not detected.
 
 
 

Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 
 

Virbagen Feline Omega Interferon Example 3 (no seroconversion)

[gg]

Example 3 
 
A recombinant feline o-interferon preparation (Trade Name: INTERCAT) was 
administered to a 3-year-old crossbred male cat which was observed to have 
neutropenia due to a feline leukemia virus infection. 
 
On the first day of examination, the cat had a weight of 4.4 kg and a body 
temperature of 41.2.degree. C., and a complete loss of appetite; abscesses and 
vomiting were observed. 
 
Blood test results were as follows: PVC 38%, WBC 900, neutrophil 0, 
lymphocyte 900, monocyte 0, eosinophil 0, and thrombocyte 30,000. In the virus 
test, an FeLV antigen was detectable, an FIV antibody was not detectable, and a 
Parvovirus antigen was not detectable. 
 
The INTERCAT was dissolved in a physiological saline solution, and 
was subcutaneously injected at a dose of 5 MU/day for seven days. The dose was 
1.14 MU/kg per cat weight. A transfusion (lactate Ringer's solution and 
glucose) was injected by intravenous drip infusion at a dose of 500 ml/day, and 
an antibiotic (cephalexin) was intravenously injected at a dose of 150 mg twice 
a day. 
 
On the fifth day, the cat had a body temperature of 40.4.degree. C., had no 
appetite, and had continuing diarrhea. Blood test results were as follows: PCV 
32%, WBC 10,000, neutrophil 7,300, lymphocyte 2,300, monocyte 200, eosinophil 
200, and thrombocyte 150,000. 
 
On the seventh day, the body temperature had decreased to 38.4.degree. C. 
and appetite had recovered. Blood test results were as follows: PCV 34%, WBC 
16,400, neutrophil 15,000, lymphocyte 1,400, monocyte 0, eosinophil 0, and 
thrombocyte 200,000. 
 
Significant recovery of neutrophils was observed, and abatement of 
fever and improved general condition were observed. 
 
The FeLV antigen was detectable.
 
 
 

Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 

Virbagen Feline Omega Interferon Example 2 (no seroconversion)

[gg]

The link can be found here: 
 

 
 
Example 2 
 
A recombinant feline .omega.-interferon preparation (Trade Name: INTERCAT) 
was administered to a one-and-a-half-year-old crossbred male cat which was 
observed to have neutropenia due to a feline leukemia virus infection. 
 
On the first day of examination, the cat weighed 2.9 kg and had a body 
temperature of 37.0.degree. C., that was low, and had completely lost its 
appetite. Vomiting, diarrhea, and dehydration were observed. 
 
It was confirmed that the cat did not have a Parvovirus infectious disease. 

 
Blood test results were as follows: PVC 49%, WBC 3,600, neutrophil 1,476, 
lymphocyte 1,440, monocyte 576, eosinophil 108, and thrombocyte 30,000. In the 
virus test, an FeLV antigen was detectable, an FIV antibody was not detectable, 
and a Parvovirus antigen was not detectable. 
 
The INTERCAT was dissolved in a physiological saline solution and 
was subcutaneously injected at a dose of 3 MU/day for four days. The dose was 
1.03 MU/kg per cat weight. A transfusion (lactate Ringer's solution and 
glucose) was injected by intravenous drip infusion at a dose of 500 ml/day, and 
an antibiotic (cephalexin) was intravenously injected at a dose of 100 mg twice 
a day. 
 
On the third day, the cat had a body temperature of 39.2.degree. C., had no 
appetite, and had continuing diarrhea. Blood test results were as follows: PCV 
34%, WBC 20,400, neutrophil 12,700, lymphocyte 3,700, monocyte 1,900, eosinophil 
660, and thrombocyte 50,000. On the eighth day, the body temperature had 
decreased to 38.8.degree. C. and appetite had slightly improved. The cat weighed 
2.6 kg and had slight continuing diarrhea. Blood test results were as follows: 
PVC 22%, WBC 62,900, neutrophil 53,000, lymphocyte 2,300, monocyte 6,500, 
eosinophil 1,050, and thrombocyte 200,000. 
 
The significant recovery of neutrophils was observed, and alleviation of 
fever and improved general condition were observed. 
 
After one month and again after 10 months, no abnormalities 
were observed, and thus the therapeutic efficacy of the INTERCAT was 
recognized.
 
 
 

Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 
 
 

Virbagen Feline Omega Interferon Example 1 (cat seroconverted)

[gg]

The link can be found here: 
 

 
 
"Although examples in the present invention will be described 
below, it is to be understood that the invention is not limited to these 
examples. Blood cell count is represented in units of microliters 
(/.mu.l)."
 
Example 1 
 
A recombinant feline .omega.-interferon preparation (Trade 
Name: INTERCAT) was administered to a 6-month-old crossbred male cat which was 
observed to have neutropenia due to a feline leukemia virus infection. 
 
On the first day of examination, the cat weighed 3.7 kg and 
had a body temperature of 39.5.degree. C., had completely lost its 
appetite, lost vigor, and was observed to have gingivitis and purulent 
rhinorrhea. 
 
Blood test results were as follows: PCV 41%, WBC 8,800, 
neutrophil 484, lymphocyte 3,256, monocyte 5,016, eosinophil 44, 
and thrombocyte 200,000. 
 
In the virus test, an FeLV antigen was detectable and an FIV 
antibody was not detectable. 
 
The INTERCAT was dissolved in a physiological saline 
solution, and was subcutaneously injected, at a dose of 4 MU/day, for 
three days. The dose was 1.08 MU/kg per cat weight. A transfusion 
(lactate Ringer's solution and glucose) was injected by intravenous drip 
infusion at a dose of 500 ml/day, and an antibiotic (cephalexin) was 
intravenously injected at a dose of 150 mg twice a day. 
 
On the third day, the cat regained its appetite and had a 
body temperature of 38.2.degree. C. and a weight of 3.6 kg. Blood test results 
were as follows: PCV 40%, WBC 10,100, neutrophil 2,121, lymphocyte 5,555, 
monocyte 2,121, eosinophil 303, and thrombocyte 100,000. Significant increases 
in the number of neutrophils and lymphocytes were observed, alleviation of fever 
and improved general condition were observed, and gingivitis and purulent 
rhinorrhea were cured. 
 
However, on the seventh day, the cat had a body 
temperature of 40.2.degree. C. and had lost appetite and vigor, and 
discharges from the eyes and lingual erosion were observed. Blood test results 
were as follows: PCV 29%, WBC 8,500, neutrophil 1,530, lymphocyte 2,550, 
monocyte 4,420, eosinophil 0, and thrombocyte 200,000. 
 
The INTERCAT was subcutaneously injected 4 times at a 
dose of 4 MU/day, every other day. As combined remedies, on the day 
when the INTERCAT was administered, a transfusion (lactate Ringer's solution and 
glucose) was injected by intravenous drip infusion at a dose of 500 ml/day, and 
an antibiotic (cephalexin) was intravenously injected twice a day at a dose of 
150 mg. 
 
On the 12th day, body temperature had decreased to 
38.3.degree. C., and appetite and vigor were regained. Blood test results were 
as follows: PCV 32%, WBC 17,200, neutrophil 8,084, lymphocyte 6,880, monocyte 
2,236, eosinophil 0, and thrombocyte 200,000. 
 
On the 19th day, although no abnormalities were 
observed when the cat was examined, as a precaution, a dose of 4 MU of INTERCAT 
was subcutaneously injected. 
 
After one month, it was recognized that the FeLV 
antigen level had become undetectable. The cat weighed 4.05 kg. Blood 
test results were as follows: PCV 39%, WBC 19,300, neutrophil 3,492, lymphocyte 
8,299, monocyte 1,158, eosinophil 1,351, and thrombocyte 200,000. 
 
After one year, the FeLV was also 
undetectable. The cat weighed 4.5 kg. Blood test results were as 
follows: PCV 42%, WBC 7,100, neutrophil 3,763, lymphocyte 2,982, monocyte 71, 
eosinophil 284, and thrombocyte 200,000.
 
 
Take care,
 
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle
 
 
 
 
 
 
 

Additional information for those interested in Virbagen Feline Omega Interferon

[gg]

Dear All, When I was snooping around a couple of 
years ago I found a few additional examples on its use for FeLV cats (naturally 
infected, thank gosh). I'll list each example in separate posts, but it may be 
beneficial to read the entire information. The link can be found 
here: 
 
 
 
Take care,
Glenda
 
Our FeLV/FIV kitties & other stuff:http://community.webshots.com/user/sicky_icicle