Hi all,
I recently came across a question about an interesting idea.
Does anyone know of an example of a protein binding to both Zn2+ and
Ca2+ at the same time? Are there any known well studied precedents at
all if any. Any help of insights would be very valuable.
thanks,
Neeraj
On Thursday 12 June 2008 20:15, Neeraj Kapoor wrote:
> Hi all,
> I recently came across a question about an interesting idea.
> Does anyone know of an example of a protein binding to both Zn2+ and
> Ca2+ at the same time? Are there any known well studied precedents at
> all if any. Any h
I think S100 binds both Zn and Ca.
On Thu, Jun 12, 2008 at 11:15 PM, Neeraj Kapoor <
[EMAIL PROTECTED]> wrote:
> Hi all,
> I recently came across a question about an interesting idea. Does
> anyone know of an example of a protein binding to both Zn2+ and Ca2+ at the
> same time? Are there a
Thermolysin binds a catalytic zinc and several Ca ions for structural
stability. See Holland et al. (1995) Protein Sci, 4, 1955.
Hope that helps,
Arthur Glasfeld
Department of Chemistry
Reed College
3203 SE Woodstock Blvd.
Portland, OR 97202
USA
On Jun 12, 2008, at 8:15 PM, Neeraj Kapoor wr
Hi Neeraj,
a couple of S100 proteins bind Zn2+ and Ca2+. Ca2+ binds to EF-hands;
Zn2+ binds to specific sites distinct of the EF-hands. We are
investigating Zn2+-binding by spectroscopy and crystallography. We think
that Zn2+ is like Ca2+ a kind of second messenger. If you have
questions, I a
Hi there.
Clostridial Alpha toxins (phospholipase Cs that cause gas gangrene)
bind 2-3x Zinc in the catalytic site, and 2-3 Ca in the membrane
binding domain.
See 1ca1, 1olp, 1qmd and others.
Dave
2008/6/13 Neeraj Kapoor <[EMAIL PROTECTED]>:
> Hi all,
> I recently came across a question ab
here
http://nobelprize.org/nobel_prizes/chemistry/laureates/1946/sumner-lecture.p
df)
Artem
-Original Message-
From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Neeraj
Kapoor
Sent: Thursday, June 12, 2008 11:15 PM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Protein binding
Artem Evdokimov <[EMAIL PROTECTED]>
>Subject: Re: [ccp4bb] Protein binding to Zn and Ca
>To: CCP4BB@JISCMAIL.AC.UK
>
>Concanavalin A can be made to bind Zn and Ca. Its binding site has room for
>one transition metal and one alkaline earth metal.
>
>http://www.jbc.org/
