Mahesh
This is the interpolation code for use in the $DES block, assuming that
you have values of a covariate at all observation records. If not, you
need to control the code by appropriate IF-statements or interpolate
(for observation times) at the time of data set creation:
IF(NEWIND.NE.
I would interpolate the covariate outside of NONMEM. I think doing it
within NONMEM unnecessarily complicates matters. You could use a cubic
spline within each subject to get the value of the missing variable or
your could use PROC MI in SAS to impute the missing value using the
other time values
Dear NMusers,
I wish to model a biomarker that is controlled by a time-varying variable. The
temporal pattern of this time-varying variable is irregular which makes a
parametric description of its profile somewhat difficult. I am hoping to use a
"connect the dots" approach for this exercise i.e.
Dear Dr. Hutson,
The general methodological approach with amniotic fluid PK modeling is to pool
the fluid from all the sacs at a given time point and measure the concentration
in that pooled fluid. The concentrations in the amniotic fluid are generally
modeled as a single compartment with other
Paul,
Whatever you do, I would make sure that these extra compartments have no
effect on the central compartment. I would first model the plasma
concentrations. If you see the difference, you can add categorical
covariate ("pregnant") to better describe your subset of interest. Then
fix the m
Title: Paul R
Has anyone suggestions on how best to code for data that presents
maternal plasma and multiple amniotic fluid concentrations? In
addition to multiple other data points of plasma from various doses and
routes for this tox study, I have simultaneous concentration data
from 3 mous
Director, Pharmacokinetics
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ICON Development Solutions
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Vice President, Pharmacokinetics
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ICON Development Solutions
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the division in close collaboration with the busin
Senior Scientist, Pharmacokinetics
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ICON Development Solutions
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candidate will serve as a Senior Scientist or team leader on projects;
perform analysis and documentation of all phases of analysis of
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