Hello NONMEM Users,
What is "ERROR IN LSODA: CODE -1"? Is there a list of explaned error codes
somewhere?
Thank you!
Pavel
try an additive IIV and/or RV, depending on your MOA and measurement
error pattern.
--
Confidentiality Notice: This message is private and may contain confidential
and proprietary information. If you have received this messa
Svetlana,
Can you clarify your model a bit more in terms of what is a parameter and
what is a covariate? You indicated that the DV is change from baseline. If
so, why do you have TBAS in the model? Is DV = TEFF - TBAS? If so,
it seems that your model should be written as:
DEFF = (TSLP*CP)**TA
Svetlana,
The answer depends on whether you would like to allow your effect to be
negative or not.
If yes, you need to rewrite the model so that the model allows negative
predictions, for example,
EFF = TBAS + TSLP*CP**TALP
where TSLP is allowed to be negative.
If not, then you can use the
You can do it that way, but you are throwing away data (the baseline
effect). Better to model baseline and effect. May prevent negative values
as well.
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Vinogradova Svetlana
Sent: Wed
Have a look at those two references:
J Pharmacokinet Pharmacodyn. 2009 Oct;36(5):381-405. Epub 2009 Aug 21.
Methods of utilizing baseline values for indirect response models. Woo
S, Pawaskar D, Jusko WJ.
J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):269-83. Epub 2008 Apr 30.
Approaches to handli
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for
each patient - vehicle (say baseline) and dose (treatment). We want to analyze
our dataset in terms of (treatment-baseline). So I've modified my dataset, and
now I have only one "column" of observat
