RE: [NMusers] backward integration from t-a to t

Pavel, I think one can use equation DADT(2)=C-K0*A(2) where C is the drug concentration. When K0=0, A2 is cumulative AUC. When k0>0, A2 would represent something like AUC for the interval prior to the current time The length of the interval would be proportional to 1/K0 (and equal to infinity

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[NMusers] backward integration from t-a to t

Dear Robert,   Efficacy is frequently considered a function of AUC.  (AUC is just an integral. It is obvious how to calculate AUC any software which can solve ODE.)  A disadvantage of this model of efficacy is that the effect is irreversable because AUC of concentration can only increa

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