RE: [NMusers] How to calculate confidence interval (CI) and prediction interval (PI) of individual prediction (IPRED) in NONMEM

2020-02-14 Thread Nick Holford
Hi Sam, As far as I know, the simple answer is yes. You just have to specify a CMT data item for each dose to match the $MODEL record numbering of the compartments and the rate constants used by ADVAN5 and ADVAN7. In principle you can have as many doses as you want administered to any compartm

Re: [NMusers] error message from xpose

2020-02-14 Thread Mark Sale
Bill, thanks that may be it, seems to be working, thanks Mark Mark Sale M.D. Senior Vice President, Pharmacometrics Nuventra Inc. 2525 Meridian Parkway, Suite 200 Durham, NC 27713 Phone (919)-973-0383 ms...@nuventra.com Upcoming Events: Webinar:

Re: [NMusers] How to calculate confidence interval (CI) and prediction interval (PI) of individual prediction (IPRED) in NONMEM

2020-02-14 Thread Sam Liao
Hi, I have a question on ADVAN5 and ADVAN7 related to dose event record. This is a general linear model. Can these two models allow multiple doses in compartment 1 and 3, simultaneously? Best regards, Sam Liao Pharmax Research, Inc. On 7/19/2018 11:50 AM, Bauer, Robert wrote: NONMEM 7.4

RE: [NMusers] error message from xpose

2020-02-14 Thread Bill Denney
Hi Mark, The tidyselect package has recently undergone some significant changes. I would guess that may have caused an issue with xpose which heavily uses the tidyverse. As Duy indicated, I’d suggest posting an issue to GitHub so that Ben can help. Thanks, Bill *From:* owner-nmus...@g

Re: [NMusers] error message from xpose

2020-02-14 Thread Duy Tran
Hi Mark, Can you try specifying more in the arguments for the function xpose::xpose_data? I typically include these below when I run xpose on R: xpdb <- xpose_data(runno = "001", ext = ".lst", prefix = "run", dir = "./ msale/XXX/xpose") If it doesn't work, can you post this issue on https://github

[NMusers] error message from xpose

2020-02-14 Thread Mark Sale
I know this is a NONMEM list server, but, need help with xpose, hope you'll indulge me. Moving to the latest xpose (from xpose4). I ran a model (using PSN, execute), model file called run001.mod, the $TABLE records are: $TABLE ID TIME TAD IPRED IWRES NOPRINT ONEHEADER FILE=sdtab001 $TABLE

[NMusers] Uppsala Pharmacometrics Summer School (UPSS) reminder

2020-02-14 Thread Piyanan Assawasuwannakit
Dear all, This is just a reminder that the application to the Uppsala Pharmacometrics Summer School (UPSS) closes on 1st of March. UPSS will take place in Uppsala from August 10th to 21st 2020 and is intended for PhD students with previous NONMEM(r) experience. The application form can be found

[NMusers] Pharmacometrics Leadership opportunity

2020-02-14 Thread TJ Elder
Pharmacometrics Lead This role will combine strong pharmacometric skills with a deep biological understanding. They are responsible for independently determining, planning, and executing M&S analyses for an entire drug development program in close collaboration with cross-functional colleagues

[NMusers] Certara is Growing!

2020-02-14 Thread Colette Anderson
Certara is growing Join our team of talented scientists at all levels in North America and Europe! In these roles, you will support projects for Certara's clients by working in teams with other associates, expert modelers and pharmacologists, and drug development consultants. Qualified cand