...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Vinogradova Svetlana
Sent: Wednesday, September 21, 2011 8:26 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] analysis of non-positive DV
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observa
Subject: [NMusers] analysis of non-positive DV
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for
each patient - vehicle (say baseline) and dose (treatment). We want to
analyze our dataset in terms of (treatment-baseline). So I've modified my
da
Svetlana,
The answer depends on whether you would like to allow your effect to be
negative or not.
If yes, you need to rewrite the model so that the model allows negative
predictions, for example,
EFF = TBAS + TSLP*CP**TALP
where TSLP is allowed to be negative.
If not, then you can use the
: Wednesday, September 21, 2011 8:26 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] analysis of non-positive DV
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for
each patient - vehicle (say baseline) and dose (treatment). We want to
analyze our da
Have a look at those two references:
J Pharmacokinet Pharmacodyn. 2009 Oct;36(5):381-405. Epub 2009 Aug 21.
Methods of utilizing baseline values for indirect response models. Woo
S, Pawaskar D, Jusko WJ.
J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):269-83. Epub 2008 Apr 30.
Approaches to handli
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for
each patient - vehicle (say baseline) and dose (treatment). We want to analyze
our dataset in terms of (treatment-baseline). So I've modified my dataset, and
now I have only one "column" of observat
